23 WORLD GASTROENTEROLOGY NEWS JANUARY 2015 Editorial | Expert Point of View | Gastro 2015: AGW/WGO | WDHD News | WGO & WGOF News | WGO Global Guidelines | Calendar of Events modern possibilities of identifying small intestine disease via endoscopic diagnosis, evidence that the small intestine is ceasing to be a “black box” in gastroenterology. According to the presentation, a capsule endoscopy can locate the source of occult GI bleeding) and identify lesion areas with impressive accuracy in Crohn’s disease. Moreover the combined (oral and transanal) use of double balloon enteroscopy has made it possible to examine virtually 100% of the small intestine and perform a biopsy for his-tological verification of the observed abnormalities. Many presentations were devoted to functional bowel disease. New data were presented on the pathogenetic factors of irritable bowel syndrome (IBS), including genetic predisposi-tion; increased levels of proinflamma-tory cytokines and anti-inflammatory cytokines reduction; the reduction of tight junction proteins, which leads to increased permeability in the intestinal mucosa; and variation in the composition of intestinal micro-biota. It was shown that there is a high frequency of a combination of IBS, functional dyspepsia (FD), and GERD presumably caused by com-mon pathophysiologic mechanisms in these diseases. Specialists revealed at the event that muscle relaxants are effective in treating pain in some pa-tients with IBS, and prokinetic drugs therapy are effective in gastric motility disorders in some patients with FD. Much attention was given to fatty liver and nonalcoholic steatohepatitis (NASH) as a hepatic manifestation of metabolic syndrome, which are now considered the main causes for in-creases in liver transaminases activity in many patients. Experts at the event demonstrated the possibilities af-forded by the elastometry (Fibroscan), which has a high degree of sensitivity and specificity in assessing the sever-ity of liver fibrosis. Also shown were examples of successful treatment for viral Hepatitis C: A combination of new drugs from the group of interfer-ons, protease inhibitors, and nucleo-side analogs can significantly improve the rate of elimination of the virus. The pathogenetic and clinical aspects of diseases of the pancreas were widely covered during the event, as well. Experts demonstrated the feasibility of endosonography for diagnosing pancreatic and papillary tumors, as well as how to effectively use endoscopic techniques in the treatment of patients with chronic pancreatitis (pancreatic duct stent-ing, endoscopic extraction of stones from the pancreatic ducts, drainage of pancreatic cysts). The audience’s at-tention was drawn to the importance of properly using enzymatic drugs for exocrine pancreatic insufficiency treatment and the use of high dosages in particular. Thirty-six clinical symposiums and workshops were held on the most important aspects of the pathogen-esis, diagnosis, and treatment of gastrointestinal diseases. Five master class lectures were offered, among them “Stomach Cancer in Russia - a Problem in Need of Attention,” “Poly- Russian Gastroenterology Week Plenary Session. Russian Gastroenterology Week Neurogastroenterology and Motility Section.
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