24 WORLD GASTROENTEROLOGY NEWS MAY 2016 Editorial | Expert Point of View | Gastro 2016: EGHS-WGO | WDHD News | WGO & WGOF News | WGO Global Guidelines | Calendar of Events Serrated Pathway and the Development of Colorectal Cancer Associate Professor Luigi Ricciardiello University of Bologna Bologna, Italy There is increasing acceptance that colorectal cancer (CRC) is a hetero-geneous condition characterized by distinct molecular phenotypes that develops via different pathways. A growing body of evidence sug-gests that serrated polyps — once thought to be relatively innocuous — may be precursors of CRC that develop via the serrated pathway. Data supporting this were presented at UEG Week 2015 from a study in which epigenetic and genetic analyses were performed on samples of sessile serrated adenoma/polyp (SSA/P), traditional serrated adenoma, and high-methylation CRCs (Abstract OP174). The aim was to explore the involvement of molecular alterations in the serrated pathway. The study demonstrated that SSA/P samples were highly methylated and repre-sented precursors of high-methylation CRCs with BRAF mutation. A second study, based on the optical diagnostic abilities of endoscopists working in routine practice, emphasized the need for practical, validated classification systems to facilitate the endoscopic differentiation of adenomas, hyper-plastic polyps, and SSA/P (Abstract OP322). The prospective study showed that of 360 optically diag-nosed SSA/P, only 36% were accu-rately characterized. This figure fell to 25% for polyps 1–5 mm in size. Advances in Neurogastroenterology and Motility Professor Magnus Simrén University of Gothenburg Gothenburg, Sweden New therapies in neurogastroenterol-ogy and motility are welcome since these areas affect many patients, but have few available treatment options. Data presented at UEG Week 2015 showed how prucalopride, a selective 5-HT4 receptor agonist, significantly enhances gastric emptying time and improves both symptoms and quality of life in patients with gastroparesis, compared with placebo (Abstract LB5641). The peripherally-acting μ-opioid receptor antagonist, naloxe-gol, was approved by the EMA in 2014 and data were presented on its mode of action and efficacy for the treatment of opioid-induced constipation and non-cancer pain (Abstract OP057). Fascinating new evidence was presented of a beneficial effect of the probiotic, Bifidobacterium longum, on comorbid depression and brain emotional reactivity in patients with IBS (Abstract OP162). Data from a randomized, placebo-controlled study also provided the first such evidence that a low FODMAP diet improves IBS symptoms (Abstract OP163). In addi-tion, there were further phase III data showing the efficacy of eluxadoline in managing symptoms and quality of life in patients with IBS and diarrhea (Ab-stracts OP166, OP167 and OP168). To read more about UEG Week 2015 and its many scientific high-lights access https://www.ueg.eu/ epaper/UEGWeek_2015_Summa-ryReport/ index.html! UEG Week 24/7 Your congress experience non-stop: UEG Week 24/7 features record-ings of all core scientific lectures from UEG Week Barcelona 2015 at https://www.ueg.eu/education/ueg-week- 24-7/ueg-week-247/. UEG Week 2016 in Vienna, Austria (October 15-19) Join this year’s UEG Week in Vienna, Austria! Benefit from early bird fees by registering by 12 May 2016. UEG Week is the premier platform for researchers around the world to sub-mit and present their latest findings. Abstract submission is open until 30 April 2016! More information https:// www.ueg.eu/week/! UEG Week is the largest and most prestigious meeting of its kind in Eu-rope. It has been running since 1992 and now attracts more than 14,000 people from across the world. It is the premier venue to present research findings and learn about new work in the field of gastroenterology. UEG Week is a highly interactive event, with dynamic sessions including live endoscopies and interactive symposia. Click here for more information on the scientific program.
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