Legend:  : Key Development,  : Very Important,  : Important, [no star]: Special Mention |
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Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations.
Canani RB, Cirillo P, Terrin G, Cesarano L, Spagnuolo MI, De Vincenzo A, Albano F, Passariello A, De Marco G, Manguso F, Guarino A, BMJ. 2007 Aug 18;335(7615):340 |
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Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea.
Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ, J Pediatr Gastroenterol Nutr. 2006 Apr;42(4):362-8 |
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Effect of handwashing on child health: a randomised controlled trial.
Luby SP, Agboatwalla M, Feikin DR, Painter J, Billhimer W, Altaf A, Hoekstra RM, Lancet. 2005 Jul 16-22;366(9481):225-33 |
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A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
Wang HH, Shieh MJ, Liao KF, World J Gastroenterol. 2005 Mar 14;11(10):1540-3 |
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Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial.
Kotowska M, Albrecht P, Szajewska H, Aliment Pharmacol Ther. 2005 Mar 1;21(5):583-90 |
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Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants.
Thibault H, Aubert-Jacquin C, Goulet O, J Pediatr Gastroenterol Nutr. 2004 Aug;39(2):147-52 |
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Phase III, double-blind study of depot octreotide versus placebo in the prevention of acute diarrhea in patients receiving pelvic radiation therapy: results of North Central Cancer Treatment Group N00CA.
Martenson JA, Halyard MY, Sloan JA, Proulx GM, Miller RC, Deming RL, Dick SJ, Johnson HA, Tai TH, Zhu AW, Keit J, Stien KJ, Atherton PJ, J Clin Oncol. 2008 Nov 10;26(32):5248-53 |
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Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone.
Ericsson CD, DuPont HL, Okhuysen PC, Jiang ZD, DuPont MW, J Travel Med. 2007 Sep-Oct;14(5):312-9 |
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Randomized control trial of live Lactobacillus acidophilus plus Bifidobacterium infantis in treatment of infantile acute watery diarrhea.
Vivatvakin B, Kowitdamrong E, J Med Assoc Thai. 2006 Sep;89 Suppl 3:S126-33 |
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The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia.
Agustina R, Lukito W, Firmansyah A, Suhardjo HN, Murniati D, Bindels J, Asia Pac J Clin Nutr. 2007;16(3):435-42 |
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Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea.
Zavaleta N, Figueroa D, Rivera J, Sánchez J, Alfaro S, Lönnerdal B, J Pediatr Gastroenterol Nutr. 2007 Feb;44(2):258-64 |
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Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: a randomized trial in five countries.
Awasthi S, INCLEN Childnet Zinc Effectiveness for Diarrhea (IC-ZED) Group, J Pediatr Gastroenterol Nutr. 2006 Mar;42(3):300-5 |
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Validation of a single concentration methacholine inhalation provocation test (SCIPT) in children.
Hagmolen of ten Have W, van den Berg NJ, van der Palen J, Bindels PJ, van Aalderen WM, J Asthma. 2005 Jul-Aug;42(6):419-23 |
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Gabapentin reduces rectal mechanosensitivity and increases rectal compliance in patients with diarrhoea-predominant irritable bowel syndrome.
Lee KJ, Kim JH, Cho SW, Aliment Pharmacol Ther. 2005 Nov 15;22(10):981-8 |
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Failure of dietary oligofructose to prevent antibiotic-associated diarrhoea.
Lewis S, Burmeister S, Cohen S, Brazier J, Awasthi A, Aliment Pharmacol Ther. 2005 Feb 15;21(4):469-77 |
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| Supplementary evidence: |
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Use of VSL[sharp]3 in the treatment of rotavirus diarrhea in children: preliminary results.
Dubey AP, Rajeshwari K, Chakravarty A, Famularo G, J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 1:S126-9 |
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Multicenter, double-blind, randomized comparison of wood creosote, the principal active ingredient of Seirogan, an herbal antidiarrheal medication, and loperamide in adults with acute nonspecific diarrhea.
Kuge T, Shibata T, Willett MS, Clin Ther. 2004 Oct;26(10):1644-51 |
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Oral rehydration solution containing a mixture of non-digestible carbohydrates in the treatment of acute diarrhea: a multicenter randomized placebo controlled study on behalf of the ESPGHAN working group on intestinal infections.
Hoekstra JH, Szajewska H, Zikri MA, Micetic-Turk D, Weizman Z, Papadopoulou A, Guarino A, Dias JA, Oostvogels B, J Pediatr Gastroenterol Nutr. 2004 Sep;39(3):239-45 |
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Randomized, double-blind clinical trial of a lactose-free and a lactose-containing formula in dietary management of acute childhood diarrhea.
Simakachorn N, Tongpenyai Y, Tongtan O, Varavithya W, J Med Assoc Thai. 2004 Jun;87(6):641-9 |
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Rotavirus infection in children with acute diarrhea as detected by latex agglutination, ELISA and polyacrylamide gel electrophoresis.
Altindis M, Yavru S, Simsek A, Ozkul A, Ceri A, Koc H, Indian Pediatr. 2004 Jun;41(6):590-4 |
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Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea.
Yalçin SS, Yurdakök K, Tezcan I, Oner L, J Pediatr Gastroenterol Nutr. 2004 May;38(5):494-501 |
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Safety and efficacy of a premixed, rice-based oral rehydration solution.
Maulen-Radovan I, Gutierrez-Castrellón P, Hashem M, Neylan M, Baggs G, Zaldo R, Ndife LI, Pollack PF, Santosham M, J Pediatr Gastroenterol Nutr. 2004 Feb;38(2):159-63 |
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Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial.
Bhatnagar S, Bahl R, Sharma PK, Kumar GT, Saxena SK, Bhan MK, J Pediatr Gastroenterol Nutr. 2004 Jan;38(1):34-40 |
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Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea.
Bahl R, Bhandari N, Saksena M, Strand T, Kumar GT, Bhan MK, Sommerfelt H, J Pediatr. 2002 Nov;141(5):677-82 |
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A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico.
DiCesare D, DuPont HL, Mathewson JJ, Ashley D, Martinez-Sandoval F, Pennington JE, Porter SB, Am J Gastroenterol. 2002 Oct;97(10):2585-8 |
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[Effect of racecadotril in the management of acute diarrhea in infants and children]
Cojocaru B, Bocquet N, Timsit S, Wille C, Boursiquot C, Marcombes F, Garel D, Sannier N, Chéron G, Arch Pediatr. 2002 Aug;9(8):774-9 |
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The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: a randomized controlled study.
Yavuz MN, Yavuz AA, Aydin F, Can G, Kavgaci H, Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):195-202 |
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A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
Prado D, Global Adult Racecadotril Study Group, Scand J Gastroenterol. 2002 Jun;37(6):656-61 |
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Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children.
Bhandari N, Bahl R, Taneja S, Strand T, Mølbak K, Ulvik RJ, Sommerfelt H, Bhan MK, Pediatrics. 2002 Jun;109(6):e86 |
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Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children.
Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, Ulvik RJ, Mølbak K, Bhan MK, Sommerfelt H, Pediatrics. 2002 May;109(5):898-903 |
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[Continuous oral hydration or with fractionated doses in acute diarrhea-induced dehydration in children]
Mota-Hernández F, Gutiérrez-Camacho C, Cabrales-Martínez RG, Villa-Contreras S, Salud Publica Mex. 2002 Jan-Feb;44(1):21-5 |
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Oral bacterial therapy promotes recovery from acute diarrhea in children.
Lee MC, Lin LH, Hung KL, Wu HY, Acta Paediatr Taiwan. 2001 Sep-Oct;42(5):301-5 |