WGO Graded Evidence: Acute Diarrhea in Adults

Level: Clinical Trials: 26 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
 
  A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults.
HH Wang, MJ Shieh, KF Liao, World J Gastroenterol. 2005 Mar 14:1540-3
  Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea.
P Raghupathy, BS Ramakrishna, SP Oommen, MS Ahmed, G Priyaa, J Dziura, GP Young, HJ Binder, J Pediatr Gastroenterol Nutr. 2006 Apr:362-8
  Determinants of self-report outcome measures in people with knee osteoarthritis.
MR Maly, PA Costigan, SJ Olney, Arch Phys Med Rehabil. 2006 Jan:96-104
  Effect of handwashing on child health: a randomised controlled trial.
SP Luby, M Agboatwalla, DR Feikin, J Painter, W Billhimer, A Altaf, RM Hoekstra, Lancet. 2005 Jul 16-22:225-33
  Effects of long-term consumption of a fermented infant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy infants.
H Thibault, C Aubert-Jacquin, O Goulet, J Pediatr Gastroenterol Nutr. 2004 Aug:147-52
  Nosocomial antibiotic-associated diarrhea associated with enterotoxin-producing strains of methicillin-resistant Staphylococcus aureus.
JM Boyce, NL Havill, Am J Gastroenterol. 2005 Aug:1828-34
  Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations.
RB Canani, P Cirillo, G Terrin, L Cesarano, MI Spagnuolo, A De Vincenzo, F Albano, A Passariello, G De Marco, F Manguso, A Guarino, BMJ. 2007 Aug 18:340
  Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial.
M Kotowska, P Albrecht, H Szajewska, Aliment Pharmacol Ther. 2005 Mar 1:583-90
  Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea.
N Zavaleta, D Figueroa, J Rivera, J Sánchez, S Alfaro, B L&oeig;nnerdal, J Pediatr Gastroenterol Nutr. 2007 Feb:258-64
  Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin alone.
CD Ericsson, HL DuPont, PC Okhuysen, ZD Jiang, MW DuPont, J Travel Med. 2007 Sep-Oct:312-9
  Randomized control trial of live Lactobacillus acidophilus plus Bifidobacterium infantis in treatment of infantile acute watery diarrhea.
B Vivatvakin, E Kowitdamrong, J Med Assoc Thai. 2006 Sep:S126-33
  The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia.
R Agustina, W Lukito, A Firmansyah, HN Suhardjo, D Murniati, J Bindels, Asia Pac J Clin Nutr. 2007:435-42
  Zinc supplementation in acute diarrhea is acceptable, does not interfere with oral rehydration, and reduces the use of other medications: a randomized trial in five countries.
S Awasthi, INCLEN Childnet Zinc Effectiveness for Diarrhea (IC-ZED) Group, J Pediatr Gastroenterol Nutr. 2006 Mar:300-5
Supplementary evidence:
  A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico.
D DiCesare, HL DuPont, JJ Mathewson, D Ashley, F Martinez-Sandoval, JE Pennington, SB Porter, Am J Gastroenterol. 2002 Oct:2585-8
  A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults.
D Prado, Global Adult Racecadotril Study Group, Scand J Gastroenterol. 2002 Jun:656-61
  Continuous oral hydration or with fractionated doses in acute diarrhea-induced dehydration in children
F Mota-Hernández, C Gutiérrez-Camacho, RG Cabrales-Martínez, S Villa-Contreras, Salud Publica Mex. 2002 Jan-Feb:21-5
  Effect of racecadotril in the management of acute diarrhea in infants and children
B Cojocaru, N Bocquet, S Timsit, C Wille, C Boursiquot, F Marcombes, D Garel, N Sannier, G Chéron, Arch Pediatr. 2002 Aug:774-9
  Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children.
TA Strand, RK Chandyo, R Bahl, PR Sharma, RK Adhikari, N Bhandari, RJ Ulvik, K Mølbak, MK Bhan, H Sommerfelt, Pediatrics. 2002 May:898-903
  Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea.
R Bahl, N Bhandari, M Saksena, T Strand, GT Kumar, MK Bhan, H Sommerfelt, J Pediatr. 2002 Nov:677-82
  Oral bacterial therapy promotes recovery from acute diarrhea in children.
MC Lee, LH Lin, KL Hung, HY Wu, Acta Paediatr Taiwan. 2001 Sep-Oct:301-5
  Oral rehydration solution containing a mixture of non-digestible carbohydrates in the treatment of acute diarrhea: a multicenter randomized placebo controlled study on behalf of the ESPGHAN working gr
JH Hoekstra, H Szajewska, MA Zikri, D Micetic-Turk, Z Weizman, A Papadopoulou, A Guarino, JA Dias, B Oostvogels, J Pediatr Gastroenterol Nutr. 2004 Sep:239-45
  Randomized, double-blind clinical trial of a lactose-free and a lactose-containing formula in dietary management of acute childhood diarrhea.
N Simakachorn, Y Tongpenyai, O Tongtan, W Varavithya, J Med Assoc Thai. 2004 Jun:641-9
  Safety and efficacy of a premixed, rice-based oral rehydration solution.
I Maulen-Radovan, P Gutierrez-Castrellón, M Hashem, M Neylan, G Baggs, R Zaldo, LI Ndife, PF Pollack, M Santosham, J Pediatr Gastroenterol Nutr. 2004 Feb:159-63
  Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children.
N Bhandari, R Bahl, S Taneja, T Strand, K Mølbak, RJ Ulvik, H Sommerfelt, MK Bhan, Pediatrics. 2002 Jun:e86
  The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: a randomized controlled study.
MN Yavuz, AA Yavuz, F Aydin, G Can, H Kavgaci, Int J Radiat Oncol Biol Phys. 2002 Sep 1:195-202
  Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial.
S Bhatnagar, R Bahl, PK Sharma, GT Kumar, SK Saxena, MK Bhan, J Pediatr Gastroenterol Nutr. 2004 Jan:34-40