WGO Graded Evidence: Constipation

Level: Meta-analyses, Systematic reviews, Practice guidelines: 48 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
  Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome.
W Atkinson, S Lockhart, PJ Whorwell, B Keevil, LA Houghton, Gastroenterology. 2006 Jan:34-43
  An open-label study of chronic polyethylene glycol laxative use in chronic constipation.
JA Di Palma, MV Cleveland, J McGowan, JL Herrera, Aliment Pharmacol Ther. 2007 Mar 15:703-8
  Biofeedback is superior to laxatives for normal transit constipation due to pelvic floor dyssynergia.
G Chiarioni, WE Whitehead, V Pezza, A Morelli, G Bassotti, Gastroenterology. 2006 Mar:657-64
  Effect of tegaserod on recto-sigmoid tonic and phasic activity in constipation-predominant irritable bowel syndrome.
M Di Stefano, E Miceli, S Mazzocchi, P Tana, A Missanelli, GR Corazza, Am J Gastroenterol. 2007 Aug:1720-6
  Efficacy and safety of traditional medical therapies for chronic constipation: systematic review.
D Ramkumar, SS Rao, Am J Gastroenterol. 2005 Apr:936-71
  Review article: tegaserod -- the global experience.
WD Chey, Aliment Pharmacol Ther. 2004 Nov:15-9
  Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome.
PP van der Veek, M van den Berg, YE de Kroon, HW Verspaget, AA Masclee, Am J Gastroenterol. 2005 Nov:2510-6
  The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation.
G Bassotti, V Villanacci, CA Maurer, S Fisogni, F Di Fabio, M Cadei, A Morelli, T Panagiotis, G Cathomas, B Salerni, Gut. 2006 Jan:41-6
Breath hydrogen test after a bean meal demonstrates delayed oro-cecal transit time in children with chronic constipation.
AC Soares, HM Lederman, U Fagundes-Neto, MB de Morais, J Pediatr Gastroenterol Nutr. 2005 Aug:221-4
Cecostomy in children with defecation disorders.
HM Mousa, MM van den Berg, DA Caniano, M Hogan, C Di Lorenzo, J Hayes, Dig Dis Sci. 2006 Jan:154-60
Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study).
V Garrigues, F Mearin, X Badía, A Balboa, J Benavent, A Caballero, E Domínguez, M Díaz-Rubio, M Roset, M Figueras, M Cucala, RITMO GROUP, Aliment Pharmacol Ther. 2007 Feb 1:323-32
Chronic constipation: a survey of the patient perspective.
JF Johanson, J Kralstein, Aliment Pharmacol Ther. 2007 Mar 1:599-608
Comorbidities associated with constipation in children referred for colon manometry may mask functional diagnoses.
JT Gertken, J Cocjin, N Pehlivanov, C Danda, PE Hyman, J Pediatr Gastroenterol Nutr. 2005 Sep:328-31
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.
JI Lee, H Park, MA Kamm, IC Talbot, J Gastroenterol Hepatol. 2005 Aug:1292-8
Development of Functional Diarrhea, Constipation, Irritable Bowel Syndrome, and Dyspepsia During and After Traveling Outside the USA.
AK Tuteja, NJ Talley, SS Gelman, SC Adler, C Thompson, K Tolman, DC Hale, Dig Dis Sci. 2007 Jun 5
Epidemiology of childhood constipation: a systematic review.
MM van den Berg, MA Benninga, C Di Lorenzo, Am J Gastroenterol. 2006 Oct:2401-9
Etiologic factors of chronic constipation: review of the scientific evidence.
FW Leung, Dig Dis Sci. 2007 Feb:313-6
Functional bowel disorders.
GF Longstreth, WG Thompson, WD Chey, LA Houghton, F Mearin, RC Spiller, Gastroenterology. 2006 Apr:1480-91
In patients with slow transit constipation, the pattern of colonic transit delay does not differentiate between those with and without impaired rectal evacuation.
N Zarate, CH Knowles, M Newell, NW Garvie, MA Gladman, PJ Lunniss, SM Scott, Am J Gastroenterol. 2008 Feb:427-34
Outlet type constipation in Parkinson's disease: results of botulinum toxin treatment.
F Cadeddu, AR Bentivoglio, F Brandara, G Marniga, G Brisinda, G Maria, Aliment Pharmacol Ther. 2005 Nov 15:997-1003
Patients with irritable bowel syndrome or constipation have an increased risk for ischaemic colitis.
DC Suh, KH Kahler, IS Choi, H Shin, J Kralstein, M Shetzline, Aliment Pharmacol Ther. 2007 Mar 15:681-92
Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome.
J Tack, SJ Middleton, MC Horne, H Piessevaux, JS Bloor, NL Meyers, RM Palmer, Aliment Pharmacol Ther. 2006 Jun 1:1655-65
Safety, tolerability and satisfaction with tegaserod therapy in Asia-Pacific patients with irritable bowel syndrome with constipation.
KM Fock, A Wagner, Asia Pacific Gastroenterology Group, J Gastroenterol Hepatol. 2007 Aug:1190-8
Symptoms and pathophysiological correlations in patients with constipation and functional dyspepsia.
G Sarnelli, R Grasso, E Ierardi, F De Giorgi, MF Savarese, L Russo, G Budillon, R Cuomo, Digestion. 2005:225-30
Tegaserod: long-term treatment for irritable bowel syndrome patients with constipation in primary care.
P Layer, J Keller, S Mueller-Lissner, P Ruegg, H Loeffler, Digestion. 2005:238-44
Validation of the pediatric Rome II criteria for functional gastrointestinal disorders using the questionnaire on pediatric gastrointestinal symptoms.
A Caplan, L Walker, A Rasquin, J Pediatr Gastroenterol Nutr. 2005 Sep:305-16
Supplementary evidence:
Adult constipation: a review and clinical guide.
TQ Jacobs, RJ Pamies, J Natl Med Assoc. 2001 Jan:22-30
Consensus on the guidelines for the diagnosis and treatment of chronic constipation.
[No Authors Listed], Chin J Dig Dis. 2004:134-7
Consensus Report by the German Society of Geriatrics. What mobilizes the diabetic bowel
[No Authors Listed], MMW Fortschr Med. 2002 Sep 5:55
Constipation during pregnancy: a longitudinal survey based on self-reported symptoms and the Rome II criteria.
J Ponce, B Martínez, A Fernández, M Ponce, G Bastida, E Plá, V Garrigues, V Ortiz, Eur J Gastroenterol Hepatol. 2008 Jan:56-61
Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meeting.
GN Tytgat, RC Heading, S Muller-Lissner, MA Kamm, J Sch&oeig;lmerich, A Berstad, M Fried, S Chaussade, D Jewell, A Briggs, Aliment Pharmacol Ther. 2003 Aug 1:291-301
Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain.
KA Nyrop, OS Palsson, RL Levy, MV Korff, AD Feld, MJ Turner, WE Whitehead, Aliment Pharmacol Ther. 2007 Jul 15:237-48
Cumulative incidence of chronic constipation: a population-based study 1988-2003.
RS Choung, GR Locke 3rd, CD Schleck, AR Zinsmeister, NJ Talley, Aliment Pharmacol Ther. 2007 Dec:1521-8
Epidemiology of constipation in North America: a systematic review.
PD Higgins, JF Johanson, Am J Gastroenterol. 2004 Apr:750-9
Evaluation and treatment of constipation in children: summary of updated recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, J Pediatr Gastroenterol Nutr. 2006 Sep:405-7
Evaluation and treatment of constipation in infants and children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
Constipation Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, J Pediatr Gastroenterol Nutr. 2006 Sep:e1-13
Fiber for the treatment of hemorrhoids complications: a systematic review and meta-analysis.
P Alonso-Coello, E Mills, D Heels-Ansdell, M López-Yarto, Q Zhou, JF Johanson, G Guyatt, Am J Gastroenterol. 2006 Jan:181-8
Functional defecation disorder as a clinical subgroup of chronic constipation: Analysis of symptoms and physiological parameters.
MT Eltringham, U Khan, IM Bain, DA Wooff, A Mackie, E Jefferson, Y Yiannakou, Scand J Gastroenterol. 2008 Mar:262-9
Intestinal gas retention in patients with idiopathic slow-transit constipation.
AC Hernando-Harder, A Franke, T Wedel, M B&oeig;ttner, HJ Krammer, MV Singer, H Harder, Dig Dis Sci. 2007 Oct:2667-75
Pediatric constipation therapy using guidelines and polyethylene glycol 3350.
EA Bell, GC Wall, Ann Pharmacother. 2004 Apr:686-93
Practice guidelines for the management of constipation in adults.
SL Folden, Rehabil Nurs. 2002 Sep-Oct:169-75
Significance of Rome II-defined functional constipation in Taiwan and comparison with constipation-predominant irritable bowel syndrome.
CL Lu, FY Chang, CY Chen, JC Luo, SD Lee, Aliment Pharmacol Ther. 2006 Jul 15:429-38
Subtyping the irritable bowel syndrome by predominant bowel habit: Rome II versus Rome III.
A Ersryd, I Posserud, H Abrahamsson, M Simrén, Aliment Pharmacol Ther. 2007 Sep 15:953-61
Systematic review of sacral nerve stimulation for faecal incontinence and constipation.
ME Jarrett, G Mowatt, CM Glazener, C Fraser, RJ Nicholls, AM Grant, MA Kamm, Br J Surg. 2004 Dec:1559-69
Systematic review: the influence of geography and ethnicity in irritable bowel syndrome.
JY Kang, Aliment Pharmacol Ther. 2005 Mar 15:663-76
The burden of constipation on quality of life: results of a multinational survey.
A Wald, C Scarpignato, MA Kamm, S Mueller-Lissner, I Helfrich, C Schuijt, J Bubeck, C Limoni, O Petrini, Aliment Pharmacol Ther. 2007 Jul 15:227-36
The Paris Consensus on Childhood Constipation Terminology (PACCT) Group.
M Benninga, DC Candy, AG Catto-Smith, G Clayden, V Loening-Baucke, CD Lorenzo, S Nurko, A Staiano, J Pediatr Gastroenterol Nutr. 2005 Mar:273-5
What is the role of stimulant laxatives in the management of childhood constipation and soiling?.
KJ Price, TM Elliott, Cochrane Database Syst Rev. 2001:CD002040