Legend: : Special Mention  : Important : Very Important : Key Development |
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A dose determination study of polyethylene glycol 4000 in constipated children: factors influencing the maintenance dose.
C Dupont, B Leluyer, F Amar, N Kalach, PH Benhamou, O Mouterde, PY Vannerom, J Pediatr Gastroenterol Nutr. 2006 Feb:178-85 |
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A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation.
J Tack, S Muller-Lissner, P Bytzer, R Corinaldesi, L Chang, A Viegas, S Schnekenbuehl, C Dunger-Baldauf, P Rueegg, Gut. 2005 Dec:1707-13 |
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A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients.
P Christensen, G Bazzocchi, M Coggrave, R Abel, C Hultling, K Krogh, S Media, S Laurberg, Gastroenterology. 2006 Sep:738-47 |
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A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipation.
JA Di Palma, MV Cleveland, J McGowan, JL Herrera, Am J Gastroenterol. 2007 Sep:1964-71 |
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A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation.
JA Dipalma, MV Cleveland, J McGowan, JL Herrera, Am J Gastroenterol. 2007 Jul:1436-41 |
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Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation.
G Chiarioni, L Salandini, WE Whitehead, Gastroenterology. 2005 Jul:86-97 |
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Celiac disease in an adult Turkish population with type 1 diabetes mellitus.
C Aygun, S Uraz, T Damci, Z Osar, V Yumuk, E Akdenizli, H Ilkova, Dig Dis Sci. 2005 Aug:1462-6 |
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Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety.
JF Johanson, R Ueno, Aliment Pharmacol Ther. 2007 Jun 1:1351-61 |
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Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation.
JF Johanson, D Morton, J Geenen, R Ueno, Am J Gastroenterol. 2008 Jan:170-7 |
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Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study.
M Pimentel, S Chatterjee, EJ Chow, S Park, Y Kong, Dig Dis Sci. 2006 Aug:1297-301 |
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Polyethylene glycol 4000 vs. lactulose for the treatment of neurogenic constipation in myelomeningocele children: a randomized-controlled clinical trial.
C Rendeli, E Ausili, F Tabacco, B Focarelli, A Pantanella, C Di Rocco, O Genovese, C Fundarò, Aliment Pharmacol Ther. 2006 Apr 15:1259-65 |
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Review article: tegaserod for chronic constipation.
JF Johanson, Aliment Pharmacol Ther. 2004 Nov:20-4 |
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Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.
V Andresen, M Camilleri, IA Busciglio, A Grudell, D Burton, S McKinzie, A Foxx-Orenstein, CB Kurtz, V Sharma, JM Johnston, MG Currie, AR Zinsmeister, Gastroenterology. 2007 Sep:761-8 |
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Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome.
V Khoshoo, C Armstead, L Landry, Aliment Pharmacol Ther. 2006 Jan 1:191-6 |
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Effect of tegaserod on recto-sigmoid tonic and phasic activity in constipation-predominant irritable bowel syndrome.
M Di Stefano, E Miceli, S Mazzocchi, P Tana, A Missanelli, GR Corazza, Am J Gastroenterol. 2007 Aug:1720-6 |
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Efficacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled study.
S Kienzle-Horn, JM Vix, C Schuijt, H Peil, CC Jordan, MA Kamm, Aliment Pharmacol Ther. 2006 May 15:1479-88 |
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Efficacy of tegaserod for functional constipation in Chinese subjects: a randomized double-blind controlled trial in a single centre.
AO On Chan, AO On Chan, W Mo Hui, G Leung, WH Hu, SK Lam, BC Wong, Aliment Pharmacol Ther. 2007 Feb 15:463-9 |
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Efficacy of tegaserod in chronic constipation in men.
M Fried, JF Johanson, KA Gwee, A Wagner, E Pecher, P Rueegg, Am J Gastroenterol. 2007 Feb:362-70 |
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Review article: the safety profile of tegaserod.
P Schoenfeld, Aliment Pharmacol Ther. 2004 Nov:25-30 |
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Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipation.
S Muller-Lissner, MA Kamm, A Musoglu, DL Earnest, C Dunger-Baldauf, MA Shetzline, Am J Gastroenterol. 2006 Nov:2558-69; quiz 2671 |
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The degree of breath methane production in IBS correlates with the severity of constipation.
S Chatterjee, S Park, K Low, Y Kong, M Pimentel, Am J Gastroenterol. 2007 Apr:837-41 |
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A novel treatment for constipation-predominant irritable bowel syndrome using Padma Lax, a Tibetan herbal formula.
S Sallon, E Ben-Arye, R Davidson, H Shapiro, G Ginsberg, M Ligumsky, Digestion. 2002:161-71 |
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A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation.
J Novick, P Miner, R Krause, K Glebas, H Bliesath, G Ligozio, P Ruegg, M Lefkowitz, Aliment Pharmacol Ther. 2002 Nov:1877-88 |
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A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of tegaserod in Chinese patients with constipation-predominant irritable bowel syndrome
Tegaserod Clinical Research Group, Zhonghua Nei Ke Za Zhi. 2003 Feb:88-90 |
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Chronic constipation: a survey of the patient perspective.
JF Johanson, J Kralstein, Aliment Pharmacol Ther. 2007 Mar 1:599-608 |
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Cisapride treatment of constipation-predominant irritable bowel syndrome is not superior to placebo.
DJ Ziegenhagen, W Kruis, J Gastroenterol Hepatol. 2004 Jul:744-9 |
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Clinical inquiries. What is the most effective way for relieving constipation in children aged >1 year?
M Torres, T McGregor, L Wilder, MR Ellis, J Fam Pract. 2004 Sep:744-6 |
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Comparison of efficacy and safety of two doses of two different polyethylene glycol-based laxatives in the treatment of constipation.
S Chaussade, M Mini., Aliment Pharmacol Ther. 2003 Jan:165-72 |
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Comparison of polyethylene glycol 3350 and lactulose for treatment of chronic constipation in children.
DA Gremse, J Hixon, A Crutchfield, Clin Pediatr (Phila). 2002 May:225-9 |
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Double-blind placebo-controlled crossover study of sacral nerve stimulation for idiopathic constipation.
NJ Kenefick, CJ Vaizey, CR Cohen, RJ Nicholls, MA Kamm, Br J Surg. 2002 Dec:1570-1 |
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Effect of an oral bulking agent and a rectal laxative administered alone or in combination for the treatment of constipation.
M Bouchoucha, A Faye, B Savarieau, M Arsac, Gastroenterol Clin Biol. 2004 May:438-43 |
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Effect of renzapride on transit in constipation-predominant irritable bowel syndrome.
M Camilleri, S McKinzie, J Fox, A Foxx-Orenstein, D Burton, G Thomforde, K Baxter, AR Zinsmeister, Clin Gastroenterol Hepatol. 2004 Oct:895-904 |
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Effect of tegaserod in chronic constipation: a randomized, double-blind, controlled trial.
JF Johanson, A Wald, G Tougas, WD Chey, JS Novick, AJ Lembo, F Fordham, M Guella, B Nault, Clin Gastroenterol Hepatol. 2004 Sep:796-805 |
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Effects of an exercise and scheduled-toileting intervention on appetite and constipation in nursing home residents.
SF Simmons, JF Schnelle, J Nutr Health Aging. 2004:116-21 |
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Effects of carbonated water on functional dyspepsia and constipation.
R Cuomo, R Grasso, G Sarnelli, G Capuano, E Nicolai, G Nardone, D Pomponi, G Budillon, E Ierardi, Eur J Gastroenterol Hepatol. 2002 Sep:991-9 |
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Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation.
CE Sloots, AC Poen, R Kerstens, M Stevens, M De Pauw, JC Van Oene, SG Meuwissen, RJ Felt-Bersma, Aliment Pharmacol Ther. 2002 Apr:759-67 |
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Fiber (glucomannan) is beneficial in the treatment of childhood constipation.
V Loening-Baucke, E Miele, A Staiano, Pediatrics. 2004 Mar:e259-64 |
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May chronic childhood constipation cause oxidative stress and potential free radical damage to children?
JY Wang, YL Wang, SL Zhou, JF Zhou, Biomed Environ Sci. 2004 Sep:266-72 |
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Neurotrophin-3 improves functional constipation.
HP Parkman, SS Rao, JC Reynolds, LR Schiller, A Wald, PB Miner, AJ Lembo, JM Gordon, DA Drossman, L Waltzman, N Stambler, JM Cedarbaum, Functional Constipation Study Investigators, Am J Gastroenterol. 2003 Jun:1338-47 |
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Nurse management of intractable functional constipation: a randomised controlled trial.
CA Burnett, E Juszczak, PB Sullivan, Arch Dis Child. 2004 Aug:717-22 |
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Open-label, dose-ranging pilot study of 4 weeks of low-dose therapy with sodium phosphate tablets in chronically constipated adults.
J Medoff, S Katz, P Malik, D Pambianco, R Pruitt, J Poulos, J Rank, M Rose, Clin Ther. 2004 Sep:1479-91 |
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Overnight efficacy of polyethylene glycol laxative.
JA Di Palma, JR Smith, M Cleveland, Am J Gastroenterol. 2002 Jul:1776-9 |
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PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial.
W Voskuijl, F de Lorijn, W Verwijs, P Hogeman, J Heijmans, W Mækel, J Taminiau, M Benninga, Gut. 2004 Nov:1590-4 |
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Phenotypic variation in functional disorders of defecation.
AE Bharucha, JG Fletcher, B Seide, SJ Riederer, AR Zinsmeister, Gastroenterology. 2005 May:1199-210 |
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Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome.
J Tack, SJ Middleton, MC Horne, H Piessevaux, JS Bloor, NL Meyers, RM Palmer, Aliment Pharmacol Ther. 2006 Jun 1:1655-65 |
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Potential oxidative stress in children with chronic constipation.
JF Zhou, JG Lou, SL Zhou, JY Wang, World J Gastroenterol. 2005 Jan 21:368-71 |
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Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation.
C Koebnick, I Wagner, P Leitzmann, U Stern, HJ Zunft, Can J Gastroenterol. 2003 Nov:655-9 |
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Prospective, randomized, parallel-group trial to evaluate the effects of lactulose and polyethylene glycol-4000 on colonic flora in chronic idiopathic constipation.
Y Bouhnik, C Neut, L Raskine, C Michel, M Riottot, C Andrieux, F Guillemot, F Dyard, B Flourié, Aliment Pharmacol Ther. 2004 Apr 15:889-99 |
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Prucalopride is effective in patients with severe chronic constipation in whom laxatives fail to provide adequate relief. Results of a double-blind, placebo-controlled clinical trial.
G Coremans, R Kerstens, M De Pauw, M Stevens, Digestion. 2003:82-9 |
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Prucalopride, a systemic enterokinetic, for the treatment of constipation.
AV Emmanuel, AJ Roy, TJ Nicholls, MA Kamm, Aliment Pharmacol Ther. 2002 Jul:1347-56 |
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Reproducibility of colonic transit study in patients with chronic constipation.
YS Nam, AJ Pikarsky, SD Wexner, JJ Singh, EG Weiss, JJ Nogueras, JS Choi, YH Hwang, Dis Colon Rectum. 2001 Jan:86-92 |
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Tegaserod for the treatment of chronic constipation: a randomized, double-blind, placebo-controlled multinational study.
MA Kamm, S Muller-Lissner, NJ Talley, J Tack, G Boeckxstaens, ON Minushkin, A Kalinin, J Dzieniszewski, P Haeck, F Fordham, S Hugot-Cournez, B Nault, Am J Gastroenterol. 2005 Feb:362-72 |
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The effects of withdrawing tegaserod treatment in comparison with continuous treatment in irritable bowel syndrome patients with abdominal pain/discomfort, bloating and constipation: a clinical study.
KD Bardhan, A Forbes, CL Marsden, T Mason, G Short, Aliment Pharmacol Ther. 2004 Jul 15:213-22 |
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The efficacy of cisapride vs. placebo and diet in patients with chronic constipation.
K Altabas, A Bili., D Jurci., Z Dorosuli., M Mihanovi., M Suni.-Omejc, B Restek-Petrovi., N Tolj, Coll Antropol. 2003 Jun:197-204 |
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Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial.
GN Verne, RH Davis, ME Robinson, JM Gordon, EY Eaker, CA Sninksy, Am J Gastroenterol. 2003 May:1112-6 |