WGO Graded Evidence: Constipation

Level: Other Reading: 107 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	Chronic constipation in the elderly. Bouras EP, Tangalos EG, Gastroenterol Clin North Am. 2009 Sep;38(3):463-80
	No Role for Increased Rectal Compliance in Pediatric Functional Constipation. Berg MM, Bongers ME, Voskuijl WP, Benninga MA, Gastroenterology. 2009 Aug 21;
	Phenotypic Variation of Colonic Motor Functions in Chronic Constipation. Ravi K, Bharucha AE, Camilleri M, Rhoten D, Bakken T, Zinsmeister AR, Gastroenterology. 2009 Aug 4;
	Behavioural and new pharmacological treatments for constipation: getting thebalance right. Camilleri M, Bharucha AE., Gut. 2010 Sep;59(9):1288-96.
	Taking a lesson from microbial diarrheagenesis in the management of chronicconstipation. Bharucha AE, Waldman SA., Gastroenterology. 2010 Mar;138(3):813-7. Epub 2010 Jan 27.
	Experience with type A botulinum toxin for treatment of outlet-type constipation. G Maria, F Cadeddu, F Brandara, G Marniga, G Brisinda, Am J Gastroenterol. 2006 Nov:2570-5
	Childhood functional gastrointestinal disorders: child/adolescent. A Rasquin, C Di Lorenzo, D Forbes, E Guiraldes, JS Hyams, A Staiano, LS Walker, Gastroenterology. 2006 Apr:1527-37
	Functional bowel disorders. GF Longstreth, WG Thompson, WD Chey, LA Houghton, F Mearin, RC Spiller, Gastroenterology. 2006 Apr:1480-91
	Sacral nerve stimulation for constipation: suboptimal outcome and adverse events. Maeda Y, Lundby L, Buntzen S, Laurberg S., Dis Colon Rectum. 2010 Jul;53(7):995-9.
	Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodiumpicosulfate in patients with chronic constipation. Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, Bubeck J., Am J Gastroenterol. 2010 Apr;105(4):897-903. Epub 2010 Feb 23.
	Enteric nervous system: sensory physiology, diarrhea and constipation. Wood JD., Curr Opin Gastroenterol. 2010 Mar;26(2):102-8.
	Long-term efficacy of biofeedback therapy for dyssynergic defecation: randomized controlled trial. Rao SS, Valestin J, Brown CK, Zimmerman B, Schulze K., Am J Gastroenterol. 2010 Apr;105(4):890-6. Epub 2010 Feb 23.
	Diagnosis and treatment of pelvic floor disorders: what's new and what to do. Whitehead WE, Bharucha AE., Gastroenterology. 2010 Apr;138(4):1231-5, 1235.e1-4. Epub 2010 Feb 19.
	Efficacy of linaclotide for patients with chronic constipation. Lembo AJ, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, Jeglinski BI, Johnston JM., Gastroenterology. 2010 Mar;138(3):886-95.e1. Epub 2010 Jan 4.
	What we have learned about colonic motility: normal and disturbed. Quigley EM., Curr Opin Gastroenterol. 2010 Jan;26(1):53-60.
	Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function inhealth and pharmacokinetics in health and constipation. Manini ML, Camilleri M, Goldberg M, Sweetser S, McKinzie S, Burton D, Wong S,Kitt MM, Li YP, Zinsmeister AR., Neurogastroenterol Motil. 2010 Jan;22(1):42-9, e7-8. Epub 2009 Aug 18.
	24-Hour colonic manometry in pediatric slow transit constipation shows significant reductions in antegrade propagation. King SK, Catto-Smith AG, Stanton MP, Sutcliffe JR, Simpson D, Cook I, Dinning P, Hutson JM, Southwell BR, Am J Gastroenterol. 2008 Aug;103(8):2083-91
	Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation. Abrahamsson H, Ostlund-Lindqvist AM, Nilsson R, Simrén M, Gillberg PG, Scand J Gastroenterol. 2008;43(12):1483-8 Cat: Journal Article
	Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. Naftali T, Feingelernt H, Lesin Y, Rauchwarger A, Konikoff FM, Digestion. 2008;78(4):224-8 Cat: Journal Article
	Percutaneous endoscopic cecostomy in adults: a case series. CR Lynch, RG Jones, K Hilden, JC Wills, JC Fang, Gastrointest Endosc. 2006 Aug:279-82
	Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation-predominant irritable bowel syndrome. J Tack, SJ Middleton, MC Horne, H Piessevaux, JS Bloor, NL Meyers, RM Palmer, Aliment Pharmacol Ther. 2006 Jun 1:1655-65
	Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data. L Chang, WD Chey, L Harris, K Olden, C Surawicz, P Schoenfeld, Am J Gastroenterol. 2006 May:1069-79
	Status of sacral neuromodulation for refractory constipation. Baeten CG., Colorectal Dis. 2011 Mar;13 Suppl 2:19-22. doi: 10.1111/j.1463-1318.2010.02521.x.
	Role of clock genes in gastrointestinal motility. Hoogerwerf WA., Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G549-55. Epub 2010 Jun17.
	Clinical utility of colonic and anorectal manometry in chronic constipation. Rao SS, Singh S., J Clin Gastroenterol. 2010 Oct;44(9):597-609.
	Psychometric performance and clinical meaningfulness of the Patient Assessment ofConstipation-Quality of Life questionnaire in prucalopride (RESOLOR) trials forchronic constipation. Dubois D, Gilet H, Viala-Danten M, Tack J., Neurogastroenterol Motil. 2010 Feb;22(2):e54-63. Epub 2009 Sep 17.
	Familial Clustering of Habitual Constipation: A Prospective Study in Children From West Virginia. Ostwani W, Dolan J, Elitsur Y, J Pediatr Gastroenterol Nutr. 2009 Aug 4;
	Clinical presentation and patterns of slow transit constipation do not predict coexistent upper gut dysmotility. Zarate N, Knowles CH, Yazaki E, Lunnis PJ, Scott SM, Dig Dis Sci. 2009 Jan;54(1):122-31
	Ambulatory care for constipation in the United States, 1993-2004. Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ, Am J Gastroenterol. 2008 Jul;103(7):1746-53
	Gallbladder motility in children with chronic constipation. Veras Neto MC, Yamada RM, da Costa Pinto EA, J Pediatr Gastroenterol Nutr 2008 Apr;46(4):414-8
	Systematic review: the adverse effects of sodium phosphate enema. J Mendoza, J Legido, S Rubio, JP Gisbert, Aliment Pharmacol Ther. 2007 Jul 1:9-20
	Review article: Chronic constipation and food hypersensitivity--an intriguing relationship. A Carroccio, G Iacono, Aliment Pharmacol Ther. 2006 Nov 1:1295-304
	Epidemiology of childhood constipation: a systematic review. MM van den Berg, MA Benninga, C Di Lorenzo, Am J Gastroenterol. 2006 Oct:2401-9
	Colorectal motor and sensitivity features in patients affected by ulcerative proctitis with constipation: a radiological and manometric controlled study. P Crispino, FI Habib, D Badiali, R Pica, F Iacopini, A Bella, C Cassieri, F Anzini, P Paoluzi, Inflamm Bowel Dis. 2006 Aug:712-8
	Childhood functional gastrointestinal disorders: neonate/toddler. PE Hyman, PJ Milla, MA Benninga, GP Davidson, DF Fleisher, J Taminiau, Gastroenterology. 2006 Apr:1519-26
	Food intolerance and chronic constipation: manometry and histology study. G Iacono, S Bonventre, C Scalici, E Maresi, L Di Prima, M Soresi, G Di Gesù, D Noto, A Carroccio, Eur J Gastroenterol Hepatol. 2006 Feb:143-50
	Fiber for the treatment of hemorrhoids complications: a systematic review and meta-analysis. P Alonso-Coello, E Mills, D Heels-Ansdell, M López-Yarto, Q Zhou, JF Johanson, G Guyatt, Am J Gastroenterol. 2006 Jan:181-8
	ASGE guideline: guideline on the use of endoscopy in the management of constipation. W Qureshi, DG Adler, RE Davila, J Egan, WK Hirota, BC Jacobson, JA Leighton, E Rajan, MJ Zuckerman, R Fanelli, J Wheeler-Harbaugh, TH Baron, DO Faigel, Gastrointest Endosc. 2005 Aug:199-201
	Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. M Guilera, A Balboa, F Mearin, Am J Gastroenterol. 2005 May:1174-84
Supplementary evidence:
	Methanogenic Flora Is Associated With Altered Colonic Transit but Not Stool Characteristics in Constipation Without IBS. Attaluri A, Jackson M, Valestin J, Rao SS, Am J Gastroenterol. 2009 Dec 1;
	Wireless capsule motility: comparison of the SmartPill GI monitoring system with scintigraphy for measuring whole gut transit. Maqbool S, Parkman HP, Friedenberg FK, Dig Dis Sci. 2009 Oct;54(10):2167-74
	Long-term outcome of functional childhood constipation. S Khan, J Campo, JA Bridge, LC Chiappetta, A Wald, C di Lorenzo, Dig Dis Sci. 2007 Jan:64-9
	Healthcare seeking for constipation: a population-based survey in the Mediterranean area of Spain. C Gálvez, V Garrigues, V Ortiz, M Ponce, P Nos, J Ponce, Aliment Pharmacol Ther. 2006 Jul 15:421-8
	Significance of Rome II-defined functional constipation in Taiwan and comparison with constipation-predominant irritable bowel syndrome. CL Lu, FY Chang, CY Chen, JC Luo, SD Lee, Aliment Pharmacol Ther. 2006 Jul 15:429-38
	Measurement of gastrointestinal transit. HC Lin, C Prather, RS Fisher, JH Meyer, RW Summers, M Pimentel, RW McCallum, LM Akkermans, V Loening-Baucke, AMS Task Force Committee on Gastrointestinal Transit, Dig Dis Sci. 2005 Jun:989-1004
	Role of progesterone signaling in the regulation of G-protein levels in female chronic constipation. ZL Xiao, V Pricolo, P Biancani, J Behar, Gastroenterology. 2005 Mar:667-75
	Obstipation as a paraneoplastic presentation of small cell lung cancer: case report and literature review. S Jun, M Dimyan, KD Jones, U Ladabaum, Neurogastroenterol Motil. 2005 Feb:16-22
	Visceral sensitivity and symptoms in patients with constipation- or diarrhea-predominant irritable bowel syndrome (IBS): effect of a low-fat intraduodenal infusion. MP Caldarella, A Milano, F Laterza, F Sacco, C Balatsinou, D Lapenna, SD Pierdomenico, F Cuccurullo, M Neri, Am J Gastroenterol. 2005 Feb:383-9
	Chronic constipation and food intolerance: a model of proctitis causing constipation. A Carroccio, C Scalici, E Maresi, L Di Prima, F Cavataio, D Noto, R Porcasi, MR Averna, G Iacono, Scand J Gastroenterol. 2005 Jan:33-42
	Is constipation associated with decreased physical activity in normally active subjects? AK Tuteja, NJ Talley, SK Joos, JV Woehl, DH Hickam, Am J Gastroenterol. 2005 Jan:124-9
	Myths and misconceptions about chronic constipation. SA Muller-Lissner, MA Kamm, C Scarpignato, A Wald, Am J Gastroenterol. 2005 Jan:232-42
	Rectal hyposensitivity: a disorder of the rectal wall or the afferent pathway? An assessment using the barostat. MA Gladman, LS Dvorkin, PJ Lunniss, NS Williams, SM Scott, Am J Gastroenterol. 2005 Jan:106-14
	Responses of anal constipation to biofeedback treatment. X Fernández-Fraga, F Azpiroz, M Casaus, A Aparici, JR Malagelada, Scand J Gastroenterol. 2005 Jan:20-7
	Tegaserod is effective in the initial and retreatment of irritable bowel syndrome with constipation. S Muller-Lissner, G Holtmann, P Rueegg, G Weidinger, H L&oeig;ffler, Aliment Pharmacol Ther. 2005 Jan 1:11-20
	Differentiating functional constipation from constipation-predominant irritable bowel syndrome: management implications. NJ Talley, Rev Gastroenterol Disord. 2005 Winter:1-9
	Ambulatory 24-hour colonic manometry in slow-transit constipation. SS Rao, P Sadeghi, J Beaty, R Kavlock, Am J Gastroenterol. 2004 Dec:2405-16
	Health related quality of life in disorders of defecation: the Defecation Disorder List. WP Voskuijl, HJ van der Zaag-Loonen, IJ Ketel, MA Grootenhuis, BH Derkx, MA Benninga, Arch Dis Child. 2004 Dec:1124-7
	Childhood constipation: is there new light in the tunnel? MA Benninga, WP Voskuijl, JA Taminiau, J Pediatr Gastroenterol Nutr. 2004 Nov:448-64
	Polyethylene glycol 3350 without electrolytes for the treatment of functional constipation in infants and toddlers. V Loening-Baucke, R Krishna, DS Pashankar, J Pediatr Gastroenterol Nutr. 2004 Nov:536-9
	Scintigraphic assessment of slow transit constipation with special reference to right- or left-sided colonic delay. E Lundin, U Karlbom, JE Westlin, K Kairemo, B Jung, S Husin, L Pċhlman, W Graf, Colorectal Dis. 2004 Nov:499-505
	The diameter of the rectum on ultrasonography as a diagnostic tool for constipation in children with dysfunctional voiding. AJ Klijn, M Asselman, MA Vijverberg, P Dik, TP de Jong, J Urol. 2004 Nov:1986-8
	Pregnancy-related constipation. CM Prather, Curr Gastroenterol Rep. 2004 Oct:402-4
	In situ Malone antegrade continence enema in 127 patients: a 6-year experience. CD Herndon, RC Rink, MP Cain, M Lerner, M Kaefer, E Yerkes, AJ Casale, J Urol. 2004 Oct:1689-91
	Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus). SS Rao, RS Mudipalli, M Stessman, B Zimmerman, Neurogastroenterol Motil. 2004 Oct:589-96
	Life style risks of Parkinson's disease: association between decreased water intake and constipation. A Ueki, M Otsuka, J Neurol. 2004 Oct:vII18-23
	Surgical management for slow-transit constipation A Alves, B Coffin, Y Panis, Ann Chir. 2004 Oct:400-4
	Chronic constipation F Arguelles Arias, JM Herrerías Gutiérrez, Med Clin (Barc). 2004 Sep 25:389-94
	Constipation, laxative use and risk of colorectal cancer: The Miyagi Cohort Study. T Watanabe, N Nakaya, K Kurashima, S Kuriyama, Y Tsubono, I Tsuji, Eur J Cancer. 2004 Sep:2109-15
	Long-term results of the antegrade continent enema procedure for constipation in adults. NP Lees, P Hodson, J Hill, RC Pearson, I MacLennan, Colorectal Dis. 2004 Sep:362-8
	Obstructed defecation HP Bruch, F Fischer, TH Schiedeck, O Schwandner, Chirurg. 2004 Sep:861-70
	Toward a definition of colonic inertia. G Bassotti, GD Roberto, L Sediari, A Morelli, World J Gastroenterol. 2004 Sep 1:2465-7
	What is evidence based in the therapy of pelvic floor insufficiency? HP Bruch, O Schwandner, Chirurg. 2004 Sep:849
	A new questionnaire for constipation and faecal incontinence. AE Bharucha, GR Locke 3rd, BM Seide, AR Zinsmeister, Aliment Pharmacol Ther. 2004 Aug 1:355-64
	Bowel movement frequency, medical history and the risk of gallbladder cancer death: a cohort study in Japan. K Yagyu, Y Lin, Y Obata, S Kikuchi, T Ishibashi, M Kurosawa, Y Inaba, A Tamakoshi, JACC Study Group, Cancer Sci. 2004 Aug:674-8
	Dietary fibre: more than a matter of dietetics. II. Preventative and therapeutic uses F Trepel, Wien Klin Wochenschr. 2004 Aug 31:511-22
	Increased prevalence of constipation and fecal soiling in a population of obese children. L Fishman, C Lenders, C Fortunato, C Noonan, S Nurko, J Pediatr. 2004 Aug:253-4
	Peptide YY release after colectomy in slow transit constipation. WP Hopman, RM Mollen, JH Kuijpers, JB Jansen, Scand J Gastroenterol. 2004 Aug:727-30
	Polyethylene glycol for constipation in children younger than eighteen months old. S Michail, E Gendy, D Preud'Homme, A Mezoff, J Pediatr Gastroenterol Nutr. 2004 Aug:197-9
	Probiotics and prebiotics in the elderly. JM Hamilton-Miller, Postgrad Med J. 2004 Aug:447-51
	Reasons for creation of permanent ileostomy for the management of idiopathic chronic constipation. AM El-Tawil, J Gastroenterol Hepatol. 2004 Aug:844-6
	Results of 24-h manometric recording of colonic motor activity with endoluminal instillation of bisacodyl in patients with severe chronic slow transit constipation. S Hervé, G Savoye, A Behbahani, AM Leroi, P Denis, P Ducrotté, Neurogastroenterol Motil. 2004 Aug:397-402
	The role of pelvic floor dysfunction and slow colonic transit in adolescents with refractory constipation. DK Chitkara, AJ Bredenoord, F Cremonini, S Delgado-Aros, RL Smoot, M El-Youssef, D Freese, M Camilleri, Am J Gastroenterol. 2004 Aug:1579-84
	Use of Rome II criteria in childhood defecation disorders: applicability in clinical and research practice. WP Voskuijl, J Heijmans, HS Heijmans, JA Taminiau, MA Benninga, J Pediatr. 2004 Aug:213-7
	Abnormal predefecatory colonic motor patterns define constipation in obstructed defecation. PG Dinning, PA Bampton, J Andre, ML Kennedy, DZ Lubowski, DW King, IJ Cook, Gastroenterology. 2004 Jul:49-56
	MACE or caecostomy button for idiopathic constipation in children: a comparison of complications and outcomes. S Cascio, ME Flett, M De la Hunt, AM Barrett, B Jaffray, Pediatr Surg Int. 2004 Jul:484-7
	Mucosal neuroendocrine cell abnormalities in patients with chronic constipation. A Kobayashi, H Yokota, H Kobayashi, A Yamataka, T Miyano, Y Hayashida, Asian J Surg. 2004 Jul:197-201
	Percutaneous endoscopic colostomy of the left colon: a new technique for management of intractable constipation in children. DJ Rawat, M Haddad, N Geoghegan, S Clarke, JM Fell, Gastrointest Endosc. 2004 Jul:39-43
	The APN's guide to pediatric constipation management. D Mason, N Tobias, M Lutkenhoff, M Stoops, D Ferguson, Nurse Pract. 2004 Jul:13-21; quiz 22-3
	A population-based study on defecatory conditions in Japanese subjects: methods for self-evaluation. S Nakaji, M Matsuzaka, T Umeda, T Shimoyama, K Sugawara, J Sakamoto, S Wada, S Tokunaga, Tohoku J Exp Med. 2004 Jun:97-104
	Effects of laxatives: rapid relief or long-term intestinal sluggishness? A Schlegel, Pflege Z. 2004 Jun:382-5
	Recurrent vomiting and persistent gastroesophageal reflux caused by unrecognized constipation. SM Borowitz, JL Sutphen, Clin Pediatr (Phila). 2004 Jun:461-6
	The efficacy and safety of polyethylene glycol 3350 in the treatment of constipation in children. MA Kinservik, MM Friedhoff, Pediatr Nurs. 2004 May-Jun:232-7
	The use of phosphate enemas in the treatment of constipation. C Davies, Nurs Times. 2004 May 4-10:32-5
	Constipation and intestinal neuronal dysplasia type B: a clinical follow-up study. G Schimpl, E Uray, M Ratschek, ME H&oeig;llwarth, J Pediatr Gastroenterol Nutr. 2004 Mar:308-11
	Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in Spain. V Garrigues, C Gálvez, V Ortiz, M Ponce, P Nos, J Ponce, Am J Epidemiol. 2004 Mar 1:520-6
	Adolescent constipation: evaluation and management. NN Youssef, L Sanders, C Di Lorenzo, Adolesc Med Clin. 2004 Feb:37-52
	Impact of anal incontinence and chronic constipation on quality of life. H Damon, P Dumas, F Mion, Gastroenterol Clin Biol. 2004 Jan:16-20
	Management of chronic constipation. NJ Talley, Rev Gastroenterol Disord. 2004 Winter:18-24
	Categorization of dysmotility in patients with chronic constipation and its significance for management. XF Guo, MY Ke, ZF Wang, XC Fang, B Wu, YP Tu, Chin J Dig Dis. 2004:98-102
	Clinical significance of functional constipation categorized by colonic transit time and pelvic floor electromyography. GY Xiong, ZQ Zhao, Chin J Dig Dis. 2004:156-9
	Current treatment options for chronic constipation. JA DiPalma, Rev Gastroenterol Disord. 2004:S34-42
	Definitions, epidemiology, and impact of chronic constipation. NJ Talley, Rev Gastroenterol Disord. 2004:S3-S10
	Diagnosis of constipation in primary and secondary care. A Wald, Rev Gastroenterol Disord. 2004:S28-33
	New and emerging treatment options for chronic constipation. LR Schiller, Rev Gastroenterol Disord. 2004:S43-51
	Pathogenesis of slow transit and pelvic floor dysfunction: from bench to bedside. MD Crowell, Rev Gastroenterol Disord. 2004:S17-27
	Subtypes of constipation: sorting out the confusion. CM Prather, Rev Gastroenterol Disord. 2004:S11-6
	The treatment of chronic constipation in elderly people: an update. W Bosshard, R Dreher, JF Schnegg, CJ Bula, Drugs Aging. 2004:911-30