WGO Graded Evidence: Helicobacter Pylori in Developing Countries

Level: Clinical Trials: 26 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
 
  Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation.
Tanigawa T, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Oshitani N, Tarnawski AS, Arakawa T, J Gastroenterol. 2009;44 Suppl 19:8-17
  A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers.
Nichita C, Abdou AE, Maerten P, Herranz M, Mouret N, Thalmann C, Michetti PF, Dorta G, Aliment Pharmacol Ther. 2009 Nov 15;30(10):1022-9
  Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study.
RM Zagari, G Bianchi-Porro, R Fiocca, G Gasbarrini, E Roda, F Bazzoli, Gut. 2007 Apr:475-9
  Effect of a community screening for Helicobacter pylori: a 5-Yr follow-up study.
Hansen JM, Wildner-Christensen M, Hallas J, Schaffalitzky de Muckadell OB, Am J Gastroenterol 2008 May;103(5):1106-13
  Proton pump inhibitor or testing for Helicobacter pylori as the first step for patients presenting with dyspepsia? A cluster-randomized trial.
DE Jarbol, J Kragstrup, H Stovring, T Havelund, OB Schaffalitzky de Muckadell, Am J Gastroenterol. 2006 Jun:1200-8
   Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection.
Boonyaritichaikij S, Kuwabara K, Nagano J, Kobayashi K, Koga Y, Helicobacter. 2009 Jun;14(3):202-7
   Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children.
Szajewska H, Albrecht P, Topczewska-Cabanek A, J Pediatr Gastroenterol Nutr. 2009 Apr;48(4):431-6
   A randomized clinical trial to determine the efficacy of regimens containing clarithromycin, metronidazole, and amoxicillin among histologic subgroups for Helicobacter pylori eradication in a developing country.
Fischbach LA, Bravo LE, Zarama GR, Bravo JC, Ojha PR, Priest EL, Collazos T, Casabon LA, Guerrero LZ, Singh PK, Correa P, Helicobacter. 2009 Apr;14(2):100-8
   Impact of quadruple regimen of clarithromycin added to metronidazole-containing triple therapy against Helicobacter pylori infection following clarithromycin-containing triple-therapy failure.
Ueki N, Miyake K, Kusunoki M, Shindo T, Kawagoe T, Futagami S, Tsukui T, Inagaki H, Sakamoto C, Helicobacter. 2009 Apr;14(2):91-9
   Helicobacter pylori and gastroesophageal reflux disease: a case-control study.
Corley DA, Kubo A, Levin TR, Block G, Habel L, Rumore G, Quesenberry C, Buffler P, Parsonnet J, Helicobacter. 2008 Oct;13(5):352-60
   Endoscopic diagnosis of Helicobacter pylori infection by rapid urease test in bleeding peptic ulcers: a prospective case-control study.
Tang JH, Liu NJ, Cheng HT, Lee CS, Chu YY, Sung KF, Lin CH, Tsou YK, Lien JM, Cheng CL, J Clin Gastroenterol. 2009 Feb;43(2):133-9
   Helicobacter pylori eradication therapy success regarding different treatment period based on clarithromycin or metronidazole triple-therapy regimens.
Filipec Kanizaj T, Katicic M, Skurla B, Ticak M, Plecko V, Kalenic S, Helicobacter. 2009 Feb;14(1):29-35
   Failure of Helicobacter pylori treatment after regimes containing clarithromycin: new practical therapeutic options.
Sanches B, Coelho L, Moretzsohn L, Vieira G Jr, Helicobacter. 2008 Dec;13(6):572-6
   Helicobacter pylori eradication therapy may facilitate gastric ulcer healing after endoscopic mucosal resection: a prospective randomized study.
Cheon JH, Kim JH, Lee SK, Kim TI, Kim WH, Lee YC, Helicobacter. 2008 Dec;13(6):564-71
   Evaluation of two triple-therapy regimens with metronidazole or clarithromycin for the eradication of H. pylori infection in Vietnamese children: a randomized, double-blind clinical trial.
Nguyen TV, Bengtsson C, Nguyen GK, Hoang TT, Phung DC, Sörberg M, Granström M, Helicobacter. 2008 Dec;13(6):550-6
   Lafutidine versus lansoprazole in combination with clarithromycin and amoxicillin for one versus two weeks for Helicobacter pylori eradication in Korea.
Kim N, Park SH, Seo GS, Lee SW, Kim JW, Lee KJ, Shin WC, Kim TN, Park MI, Park JJ, Hong SJ, Shim KN, Kim SW, Shin YW, Chang YW, Chun HJ, Lee OJ, Jeon WJ, Park CG, Cho CM, Park CH, Won SY, Lee GH, Park KS, Shin JE, Kim HU, Park JY, Chae HS, Song GA, Kim JG, Yoon BC, Seol S, Jung HC, Chung IS, Helicobacter. 2008 Dec;13(6):542-9
   Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication.
Iijima K, Koike T, Sekine H, Abe Y, Asanuma K, Ara N, Uno K, Imatani A, Ohara S, Shimosegawa T, J Gastroenterol. 2009;44(1):47-55
  Efficacy of the Standard Quadruple Therapy Versus Triple Therapies Containing Proton Pump Inhibitor Plus Amoxicillin and Clarithromycin or Amoxicillin-Clavulanic Acid and Metronidazole for Helicobacter pylori Eradication in Children.
Dehghani SM, Erjaee A, Imanieh MH, Haghighat M, Dig Dis Sci. 2008 Nov 14;
  Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children.
Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, Salam MA, Beglinger C, Gyr N, Fuchs GJ, Gastroenterology. 2008 Nov;135(5):1534-42
  Association between hepatitis A virus and Helicobacter pylori in a developing country: the saga continues.
AR Bizri, IA Nuwayhid, GN Hamadeh, SW Steitieh, AM Choukair, UM Musharrafieh, J Gastroenterol Hepatol. 2006 Oct:1615-21
  Cost-effectiveness of and satisfaction with a Helicobacter pylori "test and treat" strategy compared with prompt endoscopy in young Asians with dyspepsia.
Mahadeva S, Chia YC, Vinothini A, Mohazmi M, Goh KL, Gut 2008 Sep;57(9):1214-20
  Effect of esomeprazole triple therapy on eradication rates of Helicobacter pylori, gastric ulcer healing and prevention of relapse in gastric ulcer patients.
Tulassay Z, Stolte M, Sjölund M, Engstrand L, Butruk E, Malfertheiner P, Dite P, Tchernev K, Wong BC, Gottlow M, Eklund S, Wrangstadh M, Nagy P, Eur J Gastroenterol Hepatol 2008 Jun;20(6):526-36
  Efficacy of a New Therapeutic Regimen Versus Two Routinely Prescribed Treatments for Eradication of Helicobacter Pylori: A Randomized, Double-Blind Study of Doxycycline, Co-Amoxiclav, and Omeprazole in Iranian Patients.
Taghavi SA, Jafari A, Eshraghian A, Dig Dis Sci. 2008 Jul 2;
  Moxifloxacine Plus Amoxicillin and Ranitidine Bismuth Citrate or Esomeprazole Triple Therapies for Helicobacter pylori Infection.
Kiliç ZM, Köksal AS, Cakal B, Nadir I, Ozin YO, Kuran S, Sahin B, Dig Dis Sci 2008 Dec;53(12):3133-3137
  Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Malfertheiner P, Schultze V, Rosenkranz B, Kaufmann SH, Ulrichs T, Novicki D, Norelli F, Contorni M, Peppoloni S, Berti D, Tornese D, Ganju J, Palla E, Rappuoli R, Scharschmidt BF, Del Giudice G, Gastroenterology. 2008 Sep;135(3):787-95
Supplementary evidence:
  Rifaximin-based regimens for eradication of Helicobacter pylori: a pilot study.
A Gasbarrini, EC Lauritano, EC Nista, M Candelli, M Gabrielli, M Santoro, MA Zocco, A Cazzato, R Finizio, V Ojetti, G Cammarota, G Gasbarrini, Dig Dis. 2006:195-200