WGO Graded Evidence: Management of Acute Viral Hepatitis

Level: Meta-analyses, Systematic reviews, Practice guidelines: 21 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	Antiviral hepatitis and antiretroviral drug interactions. C Perronne, J Hepatol. 2006:S119-25
	Treatment of viral hepatitis in HIV-coinfected patients-adverse events and their management. S Mauss, J Hepatol. 2006:S114-8
	Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. E Elinav, IZ Ben-Dov, Y Shapira, N Daudi, R Adler, D Shouval, Z Ackerman, Gastroenterology. 2006 Apr:1129-34
	Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study. J Wiegand, P Buggisch, W Boecher, S Zeuzem, CM Gelbmann, T Berg, W Kauffmann, B Kallinowski, M Cornberg, E Jaeckel, H Wedemeyer, MP Manns, German HEP-NET Acute HCV Study Group, Hepatology. 2006 Feb:250-6
	Interferon-alpha therapy within the first year after acute hepatitis C infection in hemodialysis patients: efficacy and tolerance. CM Rocha, RM Perez, JL Narciso, AP Ferreira, LB Lemos, JO Medina-Pestana, AE Silva, ML Ferraz, Eur J Gastroenterol Hepatol. 2007 Feb:119-23
	Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. C Schm&oeig;cker, KH Weylandt, L Kahlke, J Wang, H Lobeck, G Tiegs, T Berg, JX Kang, Hepatology. 2007 Apr:864-9
	Peginterferon alfa-2b therapy in acute hepatitis C: impact of onset of therapy on sustained virologic response. SM Kamal, AE Fouly, RR Kamel, B Hockenjos, A Al Tawil, KE Khalifa, Q He, MJ Koziel, KM El Naggar, J Rasenack, NH Afdhal, Gastroenterology. 2006 Mar:632-8
	Prediction of hepatic encephalopathy development in patients with severe acute hepatitis. Y Takikawa, R Endo, K Suzuki, K Fujiwara, M Omata, Fulminant Hepatitis Study Group of Japan, Dig Dis Sci. 2006 Feb:359-64
	Acute hepatitis C in Israel: a predominantly iatrogenic disease? Y Lurie, DA Landau, L Blendis, Y Baruch, E Veitsman, Z Ackermann, S Zelber-Sagie, Z Halpern, R Oren, J Gastroenterol Hepatol. 2007 Feb:158-64
	Changing prevalence, clinical features, and outcome of acute hepatitis in Spain (1982-2003). JA del Olmo, E Ornia, MA Serra, ML Garcia-Torres, A Escudero, F Rodriguez, JM Rodrigo, J Gastroenterol Hepatol. 2006 Jun:982-7
	Guanine alkylation by ethylene oxide: calculation of chemical reactivity. A Kranjc, J Mavri, J Phys Chem A Mol Spectrosc Kinet Environ Gen Theory. 2006 May 4:5740-4
	Increased age, male gender, and cirrhosis, but not steatosis or a positive viral serology, negatively impact the life expectancy of patients who undergo liver biopsy. MS Wachtel, Y Zhang, KE Kaye, M Chiriva-Internati, EE Frezza, Dig Dis Sci. 2007 Sep:2276-81
	Multiple viral hepatitis in injection drug users and associated risk factors. J Reimer, J Lorenzen, B Baetz, B Fischer, J Rehm, C Haasen, M Backmund, J Gastroenterol Hepatol. 2007 Jan:80-5
	Possible involvement of cytokine gene polymorphisms in fulminant hepatitis. M Takakura, K Tokushige, N Matsushita, E Hashimoto, K Shiratori, J Gastroenterol Hepatol. 2007 Aug:1271-7
Supplementary evidence:
	Acute and chronic hepatitis: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. WF Balistreri, MH Chang, M Ciocca, K Schwarz, G Porta, A Vegnente, GM Vergani, J Pediatr Gastroenterol Nutr. 2002:S62-73
	Comment on the consensus report, "Treatment of chronic B/D viral hepatitis and acute and chronic C virus hepatitis" HP Dienes, P Schirmacher, Z Gastroenterol. 1998 Nov:XX-XXI
	Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. S Kremer-Tal, G Narla, Y Chen, E Hod, A DiFeo, S Yea, JS Lee, M Schwartz, SN Thung, IM Fiel, M Banck, E Zimran, SS Thorgeirsson, V Mazzaferro, J Bruix, JA Martignetti, JM Llovet, SL Friedman, J Hepatol. 2007 Apr:645-54
	Interferon for acute hepatitis C. T Poynard, C Regimbeau, RP Myers, T Thevenot, V Leroy, P Mathurin, P Opolon, JP Zarski, Cochrane Database Syst Rev. 2002:CD000369
	NIH Consensus Statement on Management of Hepatitis C: 2002. [No Authors Listed], NIH Consens State Sci Statements. 2002 Jun 10-12:1-46
	The treatment of chronic viral hepatitis B/D and acute and chronic viral hepatitis C. The consensus of the German Society for Digestive and Metabolic Diseases U Hopf, C Niederau, G Kleber, WE Fleig, Z Gastroenterol. 1997 Nov:971-86
	When and how to treat acute hepatitis C? A Licata, D Di Bona, F Schepis, L Shahied, A Craxí, C Cammà, J Hepatol. 2003 Dec:1056-62