WGO Graded Evidence: Osteoporosis

Level: Meta-analyses, Systematic reviews, Practice guidelines: 24 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Richards JB, Kavvoura FK, Rivadeneira F, Styrkársdóttir U, Estrada K, Halldórsson BV, Hsu YH, Zillikens MC, Wilson SG, Mullin BH, Amin N, Aulchenko YS, Cupples LA, Deloukas P, Demissie S, Hofman A, Kong A, Karasik D, van Meurs JB, Oostra BA, Pols HA, Sigurdsson G, Thorsteinsdottir U, Soranzo N, Williams FM, Zhou Y, Ralston SH, Thorleifsson G, van Duijn CM, Kiel DP, Stefansson K, Uitterlinden AG, Ioannidis JP, Spector TD, Genetic Factors for Osteoporosis Consortium, Ann Intern Med. 2009 Oct 20;151(8):528-37
	Do guidelines matter? Implementation of the ACG and AGA osteoporosis screening guidelines in inflammatory bowel disease (IBD) patients who meet the guidelines' criteria. A Kornbluth, M Hayes, S Feldman, M Hunt, E Fried-Boxt, S Lichtiger, P Legnani, J George, J Young, Am J Gastroenterol. 2006 Jul:1546-50
	Fracture risk in people with primary biliary cirrhosis: a population-based cohort study. M Solaymani-Dodaran, TR Card, GP Aithal, J West, Gastroenterology. 2006 Dec:1752-7
	Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease. M Paganelli, C Albanese, O Borrelli, F Civitelli, N Canitano, F Viola, R Passariello, S Cucchiara, Inflamm Bowel Dis. 2007 Apr:416-23
	Intravenous pamidronate in combination with calcium and vitamin D: highly effective in the treatment of low bone mineral density in inflammatory bowel disease. PC Stokkers, M Deley, M Van Der Spek, HJ Verberne, SJ Van Deventer, DW Hommes, Scand J Gastroenterol. 2006 Feb:200-4
	Screening for osteoporosis in men: a clinical practice guideline from the American College of Physicians. Qaseem A, Snow V, Shekelle P, Hopkins R Jr, Forciea MA, Owens DK, Ann Intern Med. 2008 May 6;148(9):680-4
	Screening for osteoporosis in men: a systematic review for an American College of Physicians guideline. Liu H, Paige NM, Goldzweig CL, Wong E, Zhou A, Suttorp MJ, Munjas B, Orwoll E, Shekelle P, Ann Intern Med. 2008 May 6;148(9):685-701
	Susceptibility-guided vs. empiric retreatment of Helicobacter pylori infection after treatment failure. J Yahav, Z Samra, Y Niv, CT Evans, DJ Passaro, G Dinari, H Shmuely, Dig Dis Sci. 2006 Dec:2316-21
	Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. Qaseem A, Snow V, Shekelle P, Hopkins R Jr, Forciea MA, Owens DK, Clinical Efficacy Assessment Subcommittee of the American College of Physicians, Ann Intern Med. 2008 Sep 16;149(6):404-15
	Bone loss in Crohn's disease: exercise as a potential countermeasure. N Lee, G Radford-Smith, DR Taaffe, Inflamm Bowel Dis. 2005 Dec:1108-18
	Bones and Crohn's: risk factors associated with low bone mineral density in patients with Crohn's disease. JS Siffledeen, RN Fedorak, K Siminoski, H Jen, E Vaudan, N Abraham, H Seinhart, G Greenberg, Inflamm Bowel Dis. 2004 May:220-8
	Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy. P Miheller, G Muzes, K Rácz, A Blázovits, P Lakatos, L Herszényi, Z Tulassay, Inflamm Bowel Dis. 2007 Nov:1379-84
	Guidelines do help change behavior in the management of osteoporosis by gastroenterologists. S Kane, D Reddy, Am J Gastroenterol. 2006 Aug:1841-4
	Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease. X Roblin, JM Phelip, M Genevois, V Ducros, B Bonaz, Aliment Pharmacol Ther. 2007 Apr 1:797-804
	IBD and skeletal health: children are not small adults! FA Sylvester, Inflamm Bowel Dis. 2005 Nov:1020-3
	The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss. AR Moschen, A Kaser, B Enrich, O Ludwiczek, M Gabriel, P Obrist, AM Wolf, H Tilg, Gut. 2005 Apr:479-87
	Tumor necrosis factor-alpha haplotype is strongly associated with bone mineral density in patients with Crohn's disease. N Lee, E Fowler, S Mason, D Lincoln, DR Taaffe, G Radford-Smith, J Gastroenterol Hepatol. 2007 Jun:913-9
Supplementary evidence:
	AGA technical review on osteoporosis in gastrointestinal diseases. CN Bernstein, WD Leslie, MS Leboff, Gastroenterology. 2003 Mar:795-841
	AGA technical review on osteoporosis in hepatic disorders. WD Leslie, CN Bernstein, MS Leboff, American Gastroenterological Association Clinical Practice Commitee, Gastroenterology. 2003 Sep:941-66
	American Gastroenterological Association medical position statement: guidelines on osteoporosis in gastrointestinal diseases. [No Authors Listed], Gastroenterology. 2003 Mar:791-4
	Calcium intake and osteoporosis H Orimo, Clin Calcium. 2004 Nov:108-10
	Guidelines on the management of osteoporosis associated with chronic liver disease. JD Collier, M Ninkovic, JE Compston, Gut. 2002 Feb:i1-9
	Prevention and treatment of osteoporosis in inflammatory bowel disease. GR Lichtenstein, BE Sands, M Pazianas, Inflamm Bowel Dis. 2006 Aug:797-813
	Treatment of bone disorders in liver disease. A Parés, N Guañabens, J Hepatol. 2006 Sep:445-53