WGO Graded Evidence: Treatment of Esophageal Varices

Level: Other Reading: 78 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
 
  Infection, coagulation, and variceal bleeding in cirrhosis.
U Thalheimer, CK Triantos, DN Samonakis, D Patch, AK Burroughs, Gut. 2005 Apr:556-63
  American Gastroenterological Association Institute technical review on the management of gastric subepithelial masses.
JH Hwang, SD Rulyak, MB Kimmey, American Gastroenterological Association Institute, Gastroenterology. 2006 Jun:2217-28
  Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review.
G D'Amico, JC Garcia-Pagan, A Luca, J Bosch, Gastroenterology. 2006 Nov:1611-24
  Improved survival after variceal bleeding in patients with cirrhosis over the past two decades.
N Carbonell, A Pauwels, L Serfaty, O Fourdan, VG Lévy, R Poupon, Hepatology. 2004 Sep:652-9
  Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices.
F Kazemi, A Kettaneh, G N'kontchou, E Pinto, N Ganne-Carrie, JC Trinchet, M Beaugrand, J Hepatol. 2006 Aug:230-5
  Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis.
G Garcia-Tsao, AJ Sanyal, ND Grace, W Carey, Practice Guidelines Committee of the American Association for the Study of Liver Diseases, Practice Parameters Committee of the American College of Gastroenterology, Hepatology. 2007 Sep:922-38
  Primary prophylaxis for variceal bleeding: are we there yet?
TD Boyer, Gastroenterology. 2005 Apr:1120-2
  Recurrent variceal bleeding despite endoscopic and medical therapy.
AA Mihas, AJ Sanyal, Gastroenterology. 2004 Aug:621-9
  Transjugular intrahepatic portosystemic stent shunt (TIPSS) modification in the management of post-TIPSS refractory hepatic encephalopathy.
N Kochar, D Tripathi, H Ireland, DN Redhead, PC Hayes, Gut. 2006 Nov:1617-23
  An evaluation of emergency sclerotherapy of varices in randomized trials: looking the needle in the eye.
CK Triantos, J Goulis, D Patch, GV Papatheodoridis, G Leandro, D Samonakis, E Cholongitas, AK Burroughs, Endoscopy. 2006 Aug:797-807
  ASGE Guideline: the role of endoscopy in the management of variceal hemorrhage, updated July 2005.
W Qureshi, DG Adler, R Davila, J Egan, W Hirota, J Leighton, E Rajan, MJ Zuckerman, R Fanelli, J Wheeler-Harbaugh, TH Baron, DO Faigel, Standards of Practice Committee, Gastrointest Endosc. 2005 Nov:651-5
  Characteristics of oesophageal bolus transport in patients with mild oesophagitis.
GR Domingues, R Winograd, EM Lemme, F Lammert, J Silny, S Matern, HN Nguyen, Eur J Gastroenterol Hepatol. 2005 Mar:323-32
  Endoscopic ultrasonograph evaluation of vascular structures in the gastric cardia predicts esophageal variceal recurrence following endoscopic treatment.
H Seno, Y Konishi, M Wada, H Fukui, K Okazaki, T Chiba, J Gastroenterol Hepatol. 2006 Jan:227-31
  Factors predicting success of endoscopic variceal ligation for secondary prophylaxis of esophageal variceal bleeding.
GC Harewood, TH Baron, LM Song, J Gastroenterol Hepatol. 2006 Jan:237-41
  Improved clinical outcome with transjugular intrahepatic portosystemic stent-shunt utilizing polytetrafluoroethylene-covered stents.
D Tripathi, J Ferguson, H Barkell, K Macbeth, H Ireland, DN Redhead, PC Hayes, Eur J Gastroenterol Hepatol. 2006 Mar:225-32
  Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial.
J Bosch, D Thabut, F Bendtsen, G D'Amico, A Albillos, J González Abraldes, S Fabricius, E Erhardtsen, R de Franchis, European Study Group on rFVIIa in UGI Haemorrhage, Gastroenterology. 2004 Oct:1123-30
  Review article: a critical comparison of drug therapies in currently used therapeutic strategies for variceal haemorrhage.
F Nevens, Aliment Pharmacol Ther. 2004 Sep:18-22; discussion 23
  Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding.
A Dell'era, J Bosch, Aliment Pharmacol Ther. 2004 Sep:8-15; discussion 16-7
  Value of the hepatic venous pressure gradient to monitor drug therapy for portal hypertension: a meta-analysis.
A Albillos, R Bañares, M González, C Ripoll, R Gonzalez, MV Catalina, LM Molinero, Am J Gastroenterol. 2007 May:1116-26
  Variceal band ligation versus beta-blockers for primary prevention of variceal bleeding: a meta-analysis.
D Tripathi, C Graham, PC Hayes, Eur J Gastroenterol Hepatol. 2007 Oct:835-45
   Portosystemic shunts in a large cohort of patients with liver cirrhosis: detection rate and clinical relevance.
Zardi EM, Uwechie V, Caccavo D, Pellegrino NM, Cacciapaglia F, Di Matteo F, Dobrina A, Laghi V, Afeltra A, J Gastroenterol. 2009;44(1):76-83
  Decreasing in-hospital mortality for oesophageal variceal hemorrhage in the USA.
Jamal MM, Samarasena JB, Hashemzadeh M, Eur J Gastroenterol Hepatol. 2008 Oct;20(10):947-55
  A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos).
Seewald S, Ang TL, Imazu H, Naga M, Omar S, Groth S, Seitz U, Zhong Y, Thonke F, Soehendra N, Gastrointest Endosc. 2008 Sep;68(3):447-54
  Balloon-occluded retrograde transvenous obliteration of gastric varices with gastrorenal shunt: long-term follow-up in 78 patients.
T Ninoi, N Nishida, T Kaminou, Y Sakai, T Kitayama, M Hamuro, R Yamada, K Nakamura, T Arakawa, Y Inoue, AJR Am J Roentgenol. 2005 Apr:1340-6
  Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial.
RJ Fontana, AJ Sanyal, S Mehta, MC Doherty, BA Neuschwander-Tetri, GT Everson, JA Kahn, PF Malet, MY Sheikh, RT Chung, MG Ghany, DR Gretch, HALT-C Trial Group, Am J Gastroenterol. 2006 May:983-92
  Retrograde transvenous obliteration of gastric varices associated with large collateral veins or a large gastrorenal shunt.
K Sugimori, M Morimoto, K Shirato, A Kokawa, N Tomita, K Numata, T Saito, K Tanaka, J Vasc Interv Radiol. 2005 Jan:113-8
  The effect of GI bleeding on Helicobacter pylori diagnostic testing: a prospective study at the time of bleeding and 1 month later.
LA Laine, RA Nathwani, W Naritoku, Gastrointest Endosc. 2005 Dec:853-9
Supplementary evidence:
   High-risk esophageal varices in patients treated with locoregional therapies for hepatocellular carcinoma: evaluation with regular follow-up liver CT.
Kim H, Choi D, Gwak GY, Lee JH, Lee SJ, Kim SH, Lee JY, Park Y, Chang I, Lim HK, Dig Dis Sci. 2009 Oct;54(10):2247-52
  A novel diagnostic method for evaluation of vascular lesions in the digestive tract using infrared fluorescence endoscopy.
K Okamoto, N Muguruma, T Kimura, H Yano, Y Imoto, M Takagawa, M Kaji, R Aoki, Y Sato, S Okamura, Y Kusaka, S Ito, Endoscopy. 2005 Jan:52-7
  A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices.
BM Ryan, RW Stockbrugger, JM Ryan, Gastroenterology. 2004 Apr:1175-89
  A simple technique for maximal tip deflection of an upper endoscopy.
K Hisatomi, Y Kondo, M Tauchi, T Yanagawa, Y Sakurai, Gastrointest Endosc. 2005 Jan:183-5
  Acute upper gastrointestinal variceal bleeding: vasoactive agents
A Plessier, Gastroenterol Clin Biol. 2004 Apr:B15-20
  Acute variceal bleeding
D Kravetz, Acta Gastroenterol Latinoam. 2004:88-95
  Clinical significance of variceal hemorrhage in recent years in patients with liver cirrhosis and esophageal varices.
DK Park, SH Um, JW Lee, JB Lee, YS Kim, CH Park, YT Jin, HJ Chun, HS Lee, SW Lee, JH Choi, CD Kim, HS Ryu, JH Hyun, J Gastroenterol Hepatol. 2004 Sep:1042-51
  Combination treatment of partial splenic embolization, endoscopic embolization and transjugular retrograde obliteration for complicated gastroesophageal varices.
F Chikamori, N Kuniyoshi, T Kawashima, S Shibuya, Y Takase, Hepatogastroenterology. 2004 Sep-Oct:1506-9
  Development of hepatocellular carcinoma after successful management of esophageal variceal bleeding.
WC Chen, GH Lo, KH Lai, JS Cheng, PI Hsu, CK Lin, J Chin Med Assoc. 2004 Nov:557-64
  Diagnostic model of esophageal varices in alcoholic liver disease.
A Suzuki, F Mendes, K Lindor, Eur J Gastroenterol Hepatol. 2005 Mar:307-9
  Differences in long-term survival after transjugular intrahepatic portosystemic shunt for refractory ascites and variceal bleed.
F Membreno, AL Baez, R Pandula, E Walser, DT Lau, J Gastroenterol Hepatol. 2005 Mar:474-81
  Distal embolization and local vessel wall ulceration after gastric variceal obliteration with N-butyl-2-cyanoacrylate: a case report and review of the literature.
K Kok, RP Bond, IC Duncan, PA Fourie, C Ziady, JB van den Bogaerde, SW van der Merwe, Endoscopy. 2004 May:442-6
  Does cooling Sengstaken-Blakemore tubes aid insertion? An evidence based approach.
JC Dearden, GO Hellawell, J Pilling, K Besherdas, N Van Someren, Eur J Gastroenterol Hepatol. 2004 Nov:1229-32
  Early and long-term clinical and radiological follow-up results of expanded-polytetrafluoroethylene-covered stent-grafts for transjugular intrahepatic portosystemic shunt procedures.
G Maleux, F Nevens, A Wilmer, S Heye, C Verslype, M Thijs, G Wilms, Eur Radiol. 2004 Oct:1842-50
  Endoscopic ligation vs. nadolol in the prevention of first variceal bleeding in patients with cirrhosis.
GH Lo, WC Chen, MH Chen, CP Lin, CC Lo, PI Hsu, JS Cheng, KH Lai, Gastrointest Endosc. 2004 Mar:333-8
  Evaluation and non-specific management of upper gastrointestinal bleeding due to rupture of esophageal varices
A Plessier, Gastroenterol Clin Biol. 2004 Apr:B9-14
  Frequency of gastropathy and gastric varices in children with extrahepatic portal venous obstruction treated with sclerotherapy.
U Poddar, BR Thapa, K Singh, J Gastroenterol Hepatol. 2004 Nov:1253-6
  Gastrointestinal and variceal bleeding: hemodynamic studies.
J Balanzó, C Villanueva, C Aracil, Best Pract Res Clin Gastroenterol. 2004:17-22
  How to prevent first variceal bleeding?
C Bureau, Gastroenterol Clin Biol. 2004 Apr:B44-52
  How to prevent the first variceal bleeding?
E Barrière, P Calès, Gastroenterol Clin Biol. 2004 Apr:B208-17
  Incidental esophageal varices.
R De Franchis, Gastroenterology. 2004 Jun:1860-7
  Intravascular ultrasound-guided direct intrahepatic portacaval shunt: midterm follow-up.
B Petersen, C Binkert, J Vasc Interv Radiol. 2004 Sep:927-38
  Management of esophageal varices: an update from Digestive Disease Week and American Association for the Study of Liver Diseases 2003.
S Gawrieh, K Saeian, Curr Gastroenterol Rep. 2004 Jun:206-9
  Modified devascularization surgery for isolated gastric varices assessed by endoscopic ultrasonography.
JS Hsieh, WM Wang, DS Perng, CJ Huang, JY Wang, TJ Huang, Surg Endosc. 2004 Apr:666-71
  Monitoring target reduction in hepatic venous pressure gradient during pharmacological therapy of portal hypertension: a close look at the evidence.
U Thalheimer, M Mela, D Patch, AK Burroughs, Gut. 2004 Jan:143-8
  Non-endoscopic parameters for the identification of esophageal varices in patients with chronic hepatitis.
ML Gill, M Atiq, S Sattar, N Khokhar, J Pak Med Assoc. 2004 Nov:575-7
  Noninvasive markers of esophageal varices: another round, not the last.
G D'Amico, A Morabito, Hepatology. 2004 Jan:30-4
  Nonvariceal upper gastrointestinal bleeding.
L Aabakken, Endoscopy. 2005 Mar:195-200
  Novel technique of laparoscopic azygoportal disconnection for treatment of esophageal varicosis: preliminary experience with five patients.
J Danis, R Hubmann, P Pichler, A Shamiyeh, WU Wayand, Surg Endosc. 2004 Apr:702-5
  Outcomes of patients with hepatocellular carcinoma presenting with variceal bleeding.
BH Lang, RT Poon, ST Fan, J Wong, Am J Gastroenterol. 2004 Nov:2158-65
  Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients.
KC Chiu, BS Sheu, CH Chuang, Dig Dis Sci. 2005 Jun:1170-4
  Prevention and treatment of bleeding from gastric or ectopic varices or congestive gastropathy
F Oberti, Gastroenterol Clin Biol. 2004 Apr:B53-72
  Prospective evaluation of a jelly-like conducting medium for catheter US probe imaging of esophageal and duodenal lesions.
MS Soon, A Soon, DB Schembre, OS Lin, Gastrointest Endosc. 2005 Jan:133-9
  Pulmonary embolization of 2-octyl cyanoacrylate after endoscopic injection therapy for gastric variceal bleeding.
OB Rickman, JP Utz, GL Aughenbaugh, CJ Gostout, Mayo Clin Proc. 2004 Nov:1455-8
  Recombinant factor VIIa for variceal bleeding: when, why, and how?
M Jimenez-Saenz, Gastroenterology. 2005 Apr:1150-1; author reply 1151
  Review article: definition and diagnosis in portal hypertension--continued problems with the Baveno consensus?
R de Franchis, Aliment Pharmacol Ther. 2004 Sep:2-6; discussion 7
  Serum fibrosis markers can detect large oesophageal varices with a high accuracy.
G Vanbiervliet, E Barjoan-Mariné, R Anty, T Piche, P Hastier, C Rakotoarisoa, S Benzaken, P Rampal, A Tran, Eur J Gastroenterol Hepatol. 2005 Mar:333-8
  Successful balloon-occluded retrograde transvenous obliteration for ruptured gastric fundal varices in a patient with Child-Pugh C cirrhosis: case report and literature review.
Y Komorizono, K Sako, Y Kajiya, K Kamimura, N Tooru, H Nishimata, K Shigeta, K Fujisaki, Dig Dis Sci. 2004 Feb:270-4
  Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis.
A Avgerinos, A Armonis, G Stefanidis, N Mathou, J Vlachogiannakos, A Kougioumtzian, C Triantos, C Papaxoinis, S Manolakopoulos, A Panani, SA Raptis, Hepatology. 2004 Jun:1623-30
  Systematic review of HVPG measurement: statistics versus clinical applicability.
U Thalheimer, G Leandro, M Mela, D Patch, AK Burroughs, Gastroenterology. 2007 Mar:1201-2; author reply 1202-4
  The influence of the full moon on the number of admissions related to gastrointestinal bleeding.
EM Román, G Soriano, M Fuentes, ML Gálvez, C Fernández, Int J Nurs Pract. 2004 Dec:292-6
  The Minnesota tube: its use and care in bleeding esophageal and gastric varices.
B Greenwald, Gastroenterol Nurs. 2004 Sep-Oct:212-7; quiz 218-9
  TIPS reduction with use of stents or stent-grafts.
RR Saket, DY Sze, MK Razavi, ST Kee, JK Frisoli, CP Semba, MD Dake, J Vasc Interv Radiol. 2004 Jul:745-51
  Transjugular intrahepatic portosystemic shunt in Vienna--a decade later.
B Angermayr, M Cejna, F Karnel, M Gschwantler, F K&oeig;nig, J Pidlich, H Mendel, H Brunner, L Pichler, P Ferenci, J Lammer, A Gangl, M Peck-Radosavljevic, Wien Klin Wochenschr. 2004 Sep 30:608-13
  Triplex operation for portal hypertension with esophageal variceal bleeding: report of 140 cases.
LS Feng, K Li, QP Peng, XX Ma, YF Zhao, PQ Xu, XP Chen, Hepatobiliary Pancreat Dis Int. 2004 Nov:534-7
  Use of Sengstaken-Blakemore tube to stop massive upper gastrointestinal bleeding from Dieulafoy's lesion in the lower oesophagus.
KM Ho, Anaesth Intensive Care. 2004 Oct:711-4
  Use of the six-shooter ligation device in the management of bleeding esophageal varices: a developing-country experience.
WM El-Saify, FA Mourad, Dig Dis Sci. 2005 Feb:394-8
  Variceal bleeding and portal hypertension: new lights on old horizon.
DK Bhasin, I Siyad, Endoscopy. 2004 Feb:120-9
  Vasoactive drugs for the treatment of bleeding esophageal varices
J Bosch, A Dell'era, Gastroenterol Clin Biol. 2004 Apr:B186-9
  Vasopressin and terlipressin: pharmacology and its clinical relevance.
PC Kam, S Williams, FF Yoong, Anaesthesia. 2004 Oct:993-1001
  When and how to evaluate the risk of a first variceal bleeding?
R De Franchis, Gastroenterol Clin Biol. 2004 Apr:B203-7