WGO Graded Evidence: Irritable Bowel Syndrome

Level: Meta-analyses, Systematic reviews, Practice guidelines: 16 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	Bulking agents, antispasmodics and antidepressants for the treatment of irritablebowel syndrome. Ruepert L, Quartero AO, de Wit NJ, van der Heijden GJ, Rubin G, Muris JW., Cochrane Database Syst Rev. 2011 Aug 10;(8):CD003460.
	Role of clock genes in gastrointestinal motility. Hoogerwerf WA., Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G549-55. Epub 2010 Jun17.
	The efficacy of probiotics in the treatment of irritable bowel syndrome: asystematic review. Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ,Quigley EM., Gut. 2010 Mar;59(3):325-32. Epub 2008 Dec 17.
	Review article: new receptor targets for medical therapy in irritable bowel syndrome. Camilleri M, Aliment Pharmacol Ther. 2010 Jan;31(1):35-46
	Antidepressants for the treatment of abdominal pain-related functionalgastrointestinal disorders in children and adolescents. Kaminski A, Kamper A, Thaler K, Chapman A, Gartlehner G., Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008013.
	Quantitative meta-analysis identifies brain regions activated during rectaldistension in irritable bowel syndrome. Tillisch K, Mayer EA, Labus JS., Gastroenterology. 2011 Jan;140(1):91-100. Epub 2010 Aug 7.
	Systematic review: self-management support interventions for irritable bowelsyndrome. Dorn SD., Aliment Pharmacol Ther. 2010 Aug;32(4):513-21. Epub 2010 May 22.
	Meta-analysis: do irritable bowel syndrome symptoms vary between men and women? Adeyemo MA, Spiegel BM, Chang L., Aliment Pharmacol Ther. 2010 Sep;32(6):738-55. doi:10.1111/j.1365-2036.2010.04409.x. Epub 2010 Jul 22.
	Systematic review of animal models of post-infectious/post-inflammatory irritablebowel syndrome. Qin HY, Wu JC, Tong XD, Sung JJ, Xu HX, Bian ZX., J Gastroenterol. 2010 Sep 17. [Epub ahead of print]
	Systematic Review and Meta-Analysis of the Prevalence of Irritable Bowel Syndrome in Individuals With Dyspepsia. Ford AC, Marwaha A, Lim A, Moayyedi P, Clin Gastroenterol Hepatol. 2009 Jul 23;
	Do Corticotropin Releasing Factor-1 Receptors Influence Colonic Transit and Bowel Function in Females with Irritable Bowel Syndrome? Sweetser S, Camilleri M, Linker Nord SJ, Burton DD, Castenada L, Croop R, Tong G, Dockens R, Zinsmeister AR, Am J Physiol Gastrointest Liver Physiol. 2009 Apr 2;
	A Very Low-Carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome. Austin GL, Dalton CB, Hu Y, Morris CB, Hankins J, Weinland SR, Westman EC, Yancy WS Jr, Drossman DA, Clin Gastroenterol Hepatol. 2009 Mar 10;
	The Clinical Course of Postinfectious Irritable Bowel Syndrome: A Five-year Follow-up Study. Jung IS, Kim HS, Park H, Lee SI, J Clin Gastroenterol. 2009 Mar 3;
Supplementary evidence:
	Errors in the conduct of systematic reviews of pharmacological interventions for irritable bowel syndrome. Ford AC, Guyatt GH, Talley NJ, Moayyedi P, Am J Gastroenterol. 2010 Feb;105(2):280-8
	Systematic review: accuracy of symptom-based criteria for diagnosis of irritable bowel syndrome in primary care. Jellema P, van der Windt DA, Schellevis FG, van der Horst HE, Aliment Pharmacol Ther. 2009 Oct;30(7):695-706
	Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Wedlake L, A'Hern R, Russell D, Thomas K, Walters JR, Andreyev HJ, Aliment Pharmacol Ther. 2009 Oct;30(7):707-17