WGO Graded Evidence: Irritable Bowel Syndrome

Level: Clinical Trials: 15 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
 
  MicroRNA-29a Regulates Intestinal Membrane Permeability in Patients with Irritable Bowel Syndrome.
Zhou Q, Souba WW, Croce CM, Verne GN, Gut. 2009 Dec 1;
  Affective Disturbances Modulate the Neural Processing of Visceral Pain Stimuli in Irritable Bowel Syndrome: an fMRI Study.
Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER, Gut. 2009 Aug 2;
  Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: a randomized controlled study.
Ringström G, Störsrud S, Posserud I, Lundqvist S, Westman B, Simrén M, Eur J Gastroenterol Hepatol. 2010 Apr;22(4):420-8
  Pelvic floor disorders and quality of life in women with self-reported irritable bowel syndrome.
Wang J, Varma MG, Creasman JM, Subak LL, Brown JS, Thom DH, van den Eeden SK, Aliment Pharmacol Ther. 2010 Feb 1;31(3):424-31
  No change in rectal sensitivity after gut-directed hypnotherapy in children with functional abdominal pain or irritable bowel syndrome.
Vlieger AM, van den Berg MM, Menko-Frankenhuis C, Bongers ME, Tromp E, Benninga MA, Am J Gastroenterol. 2010 Jan;105(1):213-8
  Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders.
Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Gastroenterology. 2009 Oct;137(4):1261-9
   Comprehensive Self-Management for Irritable Bowel Syndrome: Randomized Trial of In-Person vs. Combined In-Person and Telephone Sessions.
Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM, Am J Gastroenterol. 2009 Aug 18;
   Do Corticotropin Releasing Factor-1 Receptors Influence Colonic Transit and Bowel Function in Females with Irritable Bowel Syndrome?
Sweetser S, Camilleri M, Linker Nord SJ, Burton DD, Castenada L, Croop R, Tong G, Dockens R, Zinsmeister AR, Am J Physiol Gastrointest Liver Physiol. 2009 Apr 2;
   A Very Low-Carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome.
Austin GL, Dalton CB, Hu Y, Morris CB, Hankins J, Weinland SR, Westman EC, Yancy WS Jr, Drossman DA, Clin Gastroenterol Hepatol. 2009 Mar 10;
   The Clinical Course of Postinfectious Irritable Bowel Syndrome: A Five-year Follow-up Study.
Jung IS, Kim HS, Park H, Lee SI, J Clin Gastroenterol. 2009 Mar 3;
 
Supplementary evidence:
   Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome.
Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S, Gowland PA, Spiller RC, Gastroenterology. 2010 Feb;138(2):469-77, 477.e1
   Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study.
Simrén M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H, Aliment Pharmacol Ther. 2010 Jan 15;31(2):218-27
   A randomized, double-blind, placebo-controlled trial of St John's wort for treating irritable bowel syndrome.
Saito YA, Rey E, Almazar-Elder AE, Harmsen WS, Zinsmeister AR, Locke GR, Talley NJ, Am J Gastroenterol. 2010 Jan;105(1):170-7
   Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions.
Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM, Am J Gastroenterol. 2009 Dec;104(12):3004-14
   Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study.
Lee S, Wu J, Ma YL, Tsang A, Guo WJ, Sung J, Aliment Pharmacol Ther. 2009 Sep 15;30(6):643-51