WGO Graded Evidence: Irritable Bowel Syndrome

Level: Clinical Trials: 29 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	MicroRNA-29a Regulates Intestinal Membrane Permeability in Patients with Irritable Bowel Syndrome. Zhou Q, Souba WW, Croce CM, Verne GN, Gut. 2009 Dec 1;
	Affective Disturbances Modulate the Neural Processing of Visceral Pain Stimuli in Irritable Bowel Syndrome: an fMRI Study. Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER, Gut. 2009 Aug 2;
	Rifaximin therapy for patients with irritable bowel syndrome withoutconstipation. Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, BorteyE, Forbes WP; TARGET Study Group., N Engl J Med. 2011 Jan 6;364(1):22-32.
	Gluten causes gastrointestinal symptoms in subjects without celiac disease: adouble-blind randomized placebo-controlled trial. Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD,Shepherd SJ, Muir JG, Gibson PR., Am J Gastroenterol. 2011 Mar;106(3):508-14; quiz 515. Epub 2011 Jan 11.
	The mast cell stabiliser ketotifen decreases visceral hypersensitivity andimproves intestinal symptoms in patients with irritable bowel syndrome. Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, SchemannM, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE., Gut. 2010 Sep;59(9):1213-21. Epub 2010 Jul 21.
	Chenodeoxycholate in females with irritable bowel syndrome-constipation: apharmacodynamic and pharmacogenetic analysis. Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.
	Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: a randomized controlled study. Ringström G, Störsrud S, Posserud I, Lundqvist S, Westman B, Simrén M, Eur J Gastroenterol Hepatol. 2010 Apr;22(4):420-8
	Pelvic floor disorders and quality of life in women with self-reported irritable bowel syndrome. Wang J, Varma MG, Creasman JM, Subak LL, Brown JS, Thom DH, van den Eeden SK, Aliment Pharmacol Ther. 2010 Feb 1;31(3):424-31
	No change in rectal sensitivity after gut-directed hypnotherapy in children with functional abdominal pain or irritable bowel syndrome. Vlieger AM, van den Berg MM, Menko-Frankenhuis C, Bongers ME, Tromp E, Benninga MA, Am J Gastroenterol. 2010 Jan;105(1):213-8
	Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Gastroenterology. 2009 Oct;137(4):1261-9
	Mindfulness training reduces the severity of irritable bowel syndrome in women:results of a randomized controlled trial. Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Mann JD, Frey W, Leniek K, Whitehead WE., Am J Gastroenterol. 2011 Sep;106(9):1678-88. doi: 10.1038/ajg.2011.184. Epub 2011Jun 21.
	Chenodeoxycholate in females with irritable bowel syndrome-constipation: apharmacodynamic and pharmacogenetic analysis. Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.
	A randomized, double-blind, placebo-controlled trial of polyethylene glycoleffects on fasting and postprandial rectal sensitivity and symptoms inhypersensitive constipation-predominant irritable bowel syndrome. Awad RA, Camacho S., Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x.
	Clinical trial on the efficacy of a new symbiotic formulation, Flortec, inpatients with acute diarrhea: a multicenter, randomized study in primary care. Grossi E, Buresta R, Abbiati R, Cerutti R; Pro-DIA study group., J Clin Gastroenterol. 2010 Sep;44 Suppl 1:S35-41.
	The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affectvisceral sensitivity to rectal distension in healthy volunteers and IBS patients. Klooker TK, Leliefeld KE, Van Den Wijngaard RM, Boeckxstaens GE., Neurogastroenterol Motil. 2011 Jan;23(1):30-5, e2. doi:10.1111/j.1365-2982.2010.01587.x. Epub 2010 Aug 16.
	Linaclotide improves abdominal pain and bowel habits in a phase IIb study ofpatients with irritable bowel syndrome with constipation. Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, O'Dea C,Baird M, Lembo AJ., Gastroenterology. 2010 Dec;139(6):1877-1886.e2. Epub 2010 Aug 27.
	Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome. Ladabaum U, Sharabidze A, Levin TR, Zhao WK, Chung E, Bacchetti P, Jin C, Grimes B, Pepin CJ., Clin Gastroenterol Hepatol. 2010 Jan;8(1):42-48.e1. Epub 2009 Sep 16.
	A randomized, double-blind, placebo-controlled trial of St John's wort fortreating irritable bowel syndrome. Saito YA, Rey E, Almazar-Elder AE, Harmsen WS, Zinsmeister AR, Locke GR, TalleyNJ., Am J Gastroenterol. 2010 Jan;105(1):170-7. Epub 2009 Oct 6.
	No change in rectal sensitivity after gut-directed hypnotherapy in children with functional abdominal pain or irritable bowel syndrome. Vlieger AM, van den Berg MM, Menko-Frankenhuis C, Bongers ME, Tromp E, BenningaMA., Am J Gastroenterol. 2010 Jan;105(1):213-8. Epub 2009 Oct 27.
	Postprandial changes in small bowel water content in healthy subjects andpatients with irritable bowel syndrome. Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S, Gowland PA, Spiller RC., Gastroenterology. 2010 Feb;138(2):469-77, 477.e1. Epub 2009 Nov 10.
	Comprehensive Self-Management for Irritable Bowel Syndrome: Randomized Trial of In-Person vs. Combined In-Person and Telephone Sessions. Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM, Am J Gastroenterol. 2009 Aug 18;
	Do Corticotropin Releasing Factor-1 Receptors Influence Colonic Transit and Bowel Function in Females with Irritable Bowel Syndrome? Sweetser S, Camilleri M, Linker Nord SJ, Burton DD, Castenada L, Croop R, Tong G, Dockens R, Zinsmeister AR, Am J Physiol Gastrointest Liver Physiol. 2009 Apr 2;
	A Very Low-Carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome. Austin GL, Dalton CB, Hu Y, Morris CB, Hankins J, Weinland SR, Westman EC, Yancy WS Jr, Drossman DA, Clin Gastroenterol Hepatol. 2009 Mar 10;
	The Clinical Course of Postinfectious Irritable Bowel Syndrome: A Five-year Follow-up Study. Jung IS, Kim HS, Park H, Lee SI, J Clin Gastroenterol. 2009 Mar 3;
Supplementary evidence:
	Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S, Gowland PA, Spiller RC, Gastroenterology. 2010 Feb;138(2):469-77, 477.e1
	Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study. Simrén M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H, Aliment Pharmacol Ther. 2010 Jan 15;31(2):218-27
	A randomized, double-blind, placebo-controlled trial of St John's wort for treating irritable bowel syndrome. Saito YA, Rey E, Almazar-Elder AE, Harmsen WS, Zinsmeister AR, Locke GR, Talley NJ, Am J Gastroenterol. 2010 Jan;105(1):170-7
	Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions. Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM, Am J Gastroenterol. 2009 Dec;104(12):3004-14
	Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Lee S, Wu J, Ma YL, Tsang A, Guo WJ, Sung J, Aliment Pharmacol Ther. 2009 Sep 15;30(6):643-51