WGO Graded Evidence: Inflammatory Bowel Disease

Level: Other Reading: 93 Abstracts

Legend:   : Special Mention  : Important  : Very Important  : Key Development
	AGA technical review on the diagnosis and management of colorectal neoplasia ininflammatory bowel disease. Farraye FA, Odze RD, Eaden J, Itzkowitz SH., Gastroenterology. 2010 Feb;138(2):746-74, 774.e1-4; quiz e12-3.
	Current misunderstandings in the management of ulcerative colitis. Ochsenkühn T, D'Haens G., Gut. 2011 Sep;60(9):1294-9. Epub 2011 Apr 19.
	Surgery for adult Crohn's disease: what is the actual risk? Bouguen G, Peyrin-Biroulet L., Gut. 2011 Sep;60(9):1178-81. Epub 2011 May 24.
	The London position statement of the World Congress of Gastroenterology onBiological Therapy for IBD with the European Crohn's and Colitis Organisation:safety. Van Assche G, Lewis JD, Lichtenstein GR, Loftus EV, Ouyang Q, Panes J, Siegel CA,Sandborn WJ, Travis SP, Colombel JF., Am J Gastroenterol. 2011 Sep;106(9):1594-602; quiz 1593, 1603. doi:10.1038/ajg.2011.211. Epub 2011 Aug 16.
	The London Position Statement of the World Congress of Gastroenterology onBiological Therapy for IBD with the European Crohn's and Colitis Organization:when to start, when to stop, which drug to choose, and how to predict response? D'Haens GR, Panaccione R, Higgins PD, Vermeire S, Gassull M, Chowers Y, HanauerSB, Herfarth H, Hommes DW, Kamm M, Löfberg R, Quary A, Sands B, Sood A,Watermeyer G, Lashner B, Lémann M, Plevy S, Reinisch W, Schreiber S, Siegel C,Targan S, Watanabe M, Feagan B, Sandborn WJ, Colombel JF, Travis S., Am J Gastroenterol. 2011 Feb;106(2):199-212; quiz 213. Epub 2010 Nov 2.
	IL-23/IL-17 axis in IBD. Sarra M, Pallone F, Macdonald TT, Monteleone G., Inflamm Bowel Dis. 2010 Oct;16(10):1808-13.
	Intestinal dendritic cells: their role in bacterial recognition, lymphocytehoming, and intestinal inflammation. Ng SC, Kamm MA, Stagg AJ, Knight SC., Inflamm Bowel Dis. 2010 Oct;16(10):1787-807.
	Review article: stem cell therapies for inflammatory bowel disease - efficacy andsafety. García-Bosch O, Ricart E, Panés J., Aliment Pharmacol Ther. 2010 Oct;32(8):939-52. doi:10.1111/j.1365-2036.2010.04439.x. Epub 2010 Aug 19.
	Perioperative anti-tumor necrosis factor therapy does not increase the rate ofearly postoperative complications in Crohn's disease. Nasir BS, Dozois EJ, Cima RR, Pemberton JH, Wolff BG, Sandborn WJ, Loftus EV,Larson DW., J Gastrointest Surg. 2010 Dec;14(12):1859-65; discussion 1865-6. Epub 2010 Sep25.
	Colon neoplasms develop early in the course of inflammatory bowel disease andprimary sclerosing cholangitis. Thackeray EW, Charatcharoenwitthaya P, Elfaki D, Sinakos E, Lindor KD., Clin Gastroenterol Hepatol. 2011 Jan;9(1):52-6. Epub 2010 Oct 1.
	A practical guide to vaccinating the inflammatory bowel disease patient. Wasan SK, Baker SE, Skolnik PR, Farraye FA., Am J Gastroenterol. 2010 Jun;105(6):1231-8. Epub 2010 Jan 26.
	Importance of mucosal healing in ulcerative colitis. Lichtenstein GR, Rutgeerts P., Inflamm Bowel Dis. 2010 Feb;16(2):338-46.
	The natural history of adult Crohn's disease in population-based cohorts. Peyrin-Biroulet L, Loftus EV Jr, Colombel JF, Sandborn WJ., Am J Gastroenterol. 2010 Feb;105(2):289-97. Epub 2009 Oct 27.
	Meta-analysis of the role of granulomas in the recurrence of Crohn disease. Simillis C, Jacovides M, Reese GE, Yamamoto T, Tekkis PP., Dis Colon Rectum. 2010 Feb;53(2):177-85.
	MicroRNA-29a Regulates Intestinal Membrane Permeability in Patients with Irritable Bowel Syndrome. Zhou Q, Souba WW, Croce CM, Verne GN, Gut. 2009 Dec 1;
	Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics. Camilleri M, Dig Dis Sci. 2009 Nov;54(11):2318-24
	Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle. Sokol H, Beaugerie L, Gut. 2009 Oct;58(10):1427-36
	Adverse events associated with common therapy regimens for moderate-to-severe Crohn's disease. Marehbian J, Arrighi HM, Hass S, Tian H, Sandborn WJ, Am J Gastroenterol. 2009 Oct;104(10):2524-33
	Advances in the understanding of mineral and bone metabolism in inflammatorybowel diseases. Ghishan FK, Kiela PR., Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G191-201. Epub 2010 Nov 18.
	Pathogenesis of postoperative recurrence in Crohn's disease. Ahmed T, Rieder F, Fiocchi C, Achkar JP., Gut. 2011 Apr;60(4):553-62. Epub 2010 Nov 29.
	The London Position Statement of the World Congress of Gastroenterology onBiological Therapy for IBD with the European Crohn's and Colitis Organisation:pregnancy and pediatrics. Mahadevan U, Cucchiara S, Hyams JS, Steinwurz F, Nuti F, Travis SP, Sandborn WJ, Colombel JF., Am J Gastroenterol. 2011 Feb;106(2):214-23; quiz 224. Epub 2010 Dec 14.
	Serologic antiglycan antibodies in inflammatory bowel disease. Lakatos PL, Papp M, Rieder F., Am J Gastroenterol. 2011 Mar;106(3):406-12. Epub 2011 Jan 18.
	Screening and diagnosis of prostate cancer in patients with ileal pouch-analanastomosis: consensus from an expert panel. Shen B, Angermeier KW, Remzi FH, Katz S., Am J Gastroenterol. 2011 Feb;106(2):186-9.
	Genetics of ulcerative colitis. Thompson AI, Lees CW., Inflamm Bowel Dis. 2011 Mar;17(3):831-48. doi: 10.1002/ibd.21375. Epub 2010 Nov12.
	Why innovation in inflammatory bowel disease drug development will impact yourpractice. Sandborn WJ., Clin Gastroenterol Hepatol. 2011 Mar;9(3):211-3.
	Outcome after surveillance of low-grade and indefinite dysplasia in patients withulcerative colitis. Pekow JR, Hetzel JT, Rothe JA, Hanauer SB, Turner JR, Hart J, Noffsinger A, HuoD, Rubin DT., Inflamm Bowel Dis. 2010 Aug;16(8):1352-6.
	Mechanisms by which inflammation may increase intestinal cancer risk ininflammatory bowel disease. O'Connor PM, Lapointe TK, Beck PL, Buret AG., Inflamm Bowel Dis. 2010 Aug;16(8):1411-20.
	Review article: the optimal medical management of acute severe ulcerativecolitis. Hart AL, Ng SC., Aliment Pharmacol Ther. 2010 Sep;32(5):615-27. doi:10.1111/j.1365-2036.2010.04392.x.
	Heads up! How the intestinal epithelium safeguards mucosal barrier immunitythrough the inflammasome and beyond. Cario E., Curr Opin Gastroenterol. 2010 Nov;26(6):583-90.
	Cyclosporine is Safe and Effective in Patients With Severe Ulcerative Colitis. Cheifetz AS, Stern J, Garud S, Goldstein E, Malter L, Moss AC, Present DH., J Clin Gastroenterol. 2011 Feb;45(2):107-12.
	Patients with IBD are exposed to high levels of ionizing radiation through CTscan diagnostic imaging: a five-year study. Kroeker KI, Lam S, Birchall I, Fedorak RN., J Clin Gastroenterol. 2011 Jan;45(1):34-9.
	Overlap, common features, and essential differences in pediatric granulomatousinflammatory bowel disease. Damen GM, van Krieken JH, Hoppenreijs E, van Os E, Tolboom JJ, Warris A, YntemaJB, Nieuwenhuis EE, Escher JC., J Pediatr Gastroenterol Nutr. 2010 Dec;51(6):690-7.
	Importance of disrupted intestinal barrier in inflammatory bowel diseases. Salim SY, Söderholm JD., Inflamm Bowel Dis. 2011 Jan;17(1):362-81. doi: 10.1002/ibd.21403. Epub 2010 Aug19.
	Misclassification of dysplasia in patients with inflammatory bowel disease:Consequences for progression rates to advanced neoplasia. van Schaik FD, Ten Kate FJ, Offerhaus GJ, Schipper ME, Vleggaar FP, van der WoudeCJ, Stokkers PC, de Jong DJ, Hommes DW, van Bodegraven AA, Siersema PD, OldenburgB; on behalf of the Dutch Initiative on Crohn and Colitis (ICC)., Inflamm Bowel Dis. 2010 Sep 7. [Epub ahead of print]
	Renal manifestations and complications of inflammatory bowel disease. Oikonomou K, Kapsoritakis A, Eleftheriadis T, Stefanidis I, Potamianos S., Inflamm Bowel Dis. 2010 Sep 14. [Epub ahead of print]
	Infectious colitis. Navaneethan U, Giannella RA., Curr Opin Gastroenterol. 2010 Sep 20. [Epub ahead of print]
	Innate and adaptive immune connections in inflammatory bowel diseases. Rakoff-Nahoum S, Bousvaros A., Curr Opin Gastroenterol. 2010 Nov;26(6):572-7.
	Looking in the mouth for Crohn's disease. Rowland M, Fleming P, Bourke B., Inflamm Bowel Dis. 2010 Feb;16(2):332-7.
	Secondary pouchitis: those with identifiable etiopathogenetic or triggeringfactors. Navaneethan U, Shen B., Am J Gastroenterol. 2010 Jan;105(1):51-64. Epub 2009 Sep 15.
	Malignant transformation in perianal fistulas of Crohn's disease: a systematicreview of literature. Thomas M, Bienkowski R, Vandermeer TJ, Trostle D, Cagir B., J Gastrointest Surg. 2010 Jan;14(1):66-73. Epub 2009 Oct 14.
	Surgical management of pyogenic complications of Crohn's disease. Cellini C, Safar B, Fleshman J., Inflamm Bowel Dis. 2010 Mar;16(3):512-7.
	Video capsule endoscopy of the small bowel. Eliakim R., Curr Opin Gastroenterol. 2010 Mar;26(2):129-33.
	Indications and detection, completion, and retention rates of small-bowel capsuleendoscopy: a systematic review. Liao Z, Gao R, Xu C, Li ZS., Gastrointest Endosc. 2010 Feb;71(2):280-6.
	Inflammation and colon cancer. Terzic J, Grivennikov S, Karin E, Karin M., Gastroenterology. 2010 Jun;138(6):2101-2114.e5.
	Pelvic floor disorders and quality of life in women with self-reported irritable bowel syndrome. Wang J, Varma MG, Creasman JM, Subak LL, Brown JS, Thom DH, van den Eeden SK, Aliment Pharmacol Ther. 2010 Feb 1;31(3):424-31
	Review article: new receptor targets for medical therapy in irritable bowel syndrome. Camilleri M, Aliment Pharmacol Ther. 2010 Jan;31(1):35-46
	Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Buhner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, Cremon C, Zeller F, Langer R, Daniel H, Michel K, Schemann M, Gastroenterology. 2009 Oct;137(4):1425-34
	Laboratory tests for patients with ileal pouch-anal anastomosis: clinical utility in predicting, diagnosing, and monitoring pouch disorders. Navaneethan U, Shen B, Am J Gastroenterol. 2009 Oct;104(10):2606-15
	Appendicectomy as a therapy for ulcerative proctitis. Bolin TD, Wong S, Crouch R, Engelman JL, Riordan SM, Am J Gastroenterol. 2009 Oct;104(10):2476-82
	Reduced endothelial progenitor cell number and function in inflammatory bowel disease: a possible link to the pathogenesis. Garolla A, D'Incà R, Checchin D, Biagioli A, De Toni L, Nicoletti V, Scarpa M, Bolzonello E, Sturniolo GC, Foresta C, Am J Gastroenterol. 2009 Oct;104(10):2500-7
	Efficacy of adalimumab in moderate-to-severe pediatric Crohn's disease. Viola F, Civitelli F, Di Nardo G, Barbato MB, Borrelli O, Oliva S, Conte F, Cucchiara S, Am J Gastroenterol. 2009 Oct;104(10):2566-71
	A population-based study of breastfeeding in inflammatory bowel disease: initiation, duration, and effect on disease in the postpartum period. Moffatt DC, Ilnyckyj A, Bernstein CN, Am J Gastroenterol. 2009 Oct;104(10):2517-23
	Psychoneuroimmunologic factors in inflammatory bowel disease. Mackner LM, Clough-Paabo E, Pajer K, Lourie A, Crandall WV., Inflamm Bowel Dis. 2011 Mar;17(3):849-57. doi: 10.1002/ibd.21430. Epub 2010 Aug18.
	Intestinal tissue kallikrein-kinin system in inflammatory bowel disease. Stadnicki A., Inflamm Bowel Dis. 2011 Feb;17(2):645-54.
	Use of complementary and alternative medicine by patients with inflammatory boweldisease. Hilsden RJ, Verhoef MJ, Rasmussen H, Porcino A, DeBruyn JC., Inflamm Bowel Dis. 2011 Feb;17(2):655-62.
	Review article: the role of non-biological drugs in refractory inflammatory boweldisease. Ng SC, Chan FK, Sung JJ., Aliment Pharmacol Ther. 2011 Feb;33(4):417-27. doi:10.1111/j.1365-2036.2010.04541.x. Epub 2010 Dec 8.
	Review article: prevention and management of hepatitis B and C infection inpatients with inflammatory bowel disease. Gisbert JP, Chaparro M, Esteve M., Aliment Pharmacol Ther. 2011 Mar;33(6):619-33.
	Multiple imputation for estimation of an occurrence rate in cohorts withattrition and discrete follow-up time points: a simulation study. Soullier N, de La Rochebrochard E, Bouyer J., BMC Med Res Methodol. 2010 Sep 3;10:79.
	Postoperative outcome of colectomy for pediatric patients with ulcerativecolitis. Patton D, Gupta N, Wojcicki JM, Garnett EA, Nobuhara K, Heyman MB., J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):151-4.
	The appropriateness of concomitant immunomodulators with anti-tumor necrosisfactor agents for Crohn's disease: one size does not fit all. Melmed GY, Spiegel BM, Bressler B, Cheifetz AS, Devlin SM, Harrell LE, Irving PM,Jones J, Kaplan GG, Kozuch PL, Velayos FS, Baidoo L, Sparrow MP, Siegel CA., Clin Gastroenterol Hepatol. 2010 Aug;8(8):655-9. Epub 2010 May 6.
	Racial disparities in utilization of specialist care and medications ininflammatory bowel disease. Nguyen GC, LaVeist TA, Harris ML, Wang MH, Datta LW, Brant SR., Am J Gastroenterol. 2010 Oct;105(10):2202-8. Epub 2010 May 18.
	Inducing and maintaining remission in ulcerative colitis: role of high-dose,extended-release mesalamine. Kao J, Kwok K, Das KM., J Clin Gastroenterol. 2010 Sep;44(8):531-5.
	Evidence of intestinal inflammation in patients with cystic fibrosis. Werlin SL, Benuri-Silbiger I, Kerem E, Adler SN, Goldin E, Zimmerman J, Malka N, Cohen L, Armoni S, Yatzkan-Israelit Y, Bergwerk A, Aviram M, Bentur L, MussaffiH, Bjarnasson I, Wilschanski M., J Pediatr Gastroenterol Nutr. 2010 Sep;51(3):304-8.
	Review article: lymphatic system and associated adipose tissue in the developmentof inflammatory bowel disease. von der Weid PY, Rainey KJ., Aliment Pharmacol Ther. 2010 Sep;32(6):697-711.
	Paneth cells and innate mucosal immunity. Ouellette AJ., Curr Opin Gastroenterol. 2010 Nov;26(6):547-53.
	Histopathology predictors of medically refractory ulcerative colitis. Melson JE, Giusto D, Kwasny M, Eichenseer P, Jakate S, Keshavarzian A., Dis Colon Rectum. 2010 Sep;53(9):1280-6.
	Psychoneuroimmunologic factors in inflammatory bowel disease. Mackner LM, Clough-Paabo E, Pajer K, Lourie A, Crandall WV., Inflamm Bowel Dis. 2010 Aug 18. [Epub ahead of print]
	The role of the macrophage in sentinel responses in intestinal immunity. Sheikh SZ, Plevy SE., Curr Opin Gastroenterol. 2010 Nov;26(6):578-82.
	Irritable bowel syndrome and small intestinal bacterial overgrowth. Yamini D, Pimentel M., J Clin Gastroenterol. 2010 Nov-Dec;44(10):672-5.
	Involvement of activation-induced cytidine deaminase in the development ofcolitis-associated colorectal cancers. Endo Y, Marusawa H, Chiba T., J Gastroenterol. 2011 Jan;46 Suppl 1:6-10. Epub 2010 Sep 28.
	The colonic microflora and probiotic therapy in health and disease. Shanahan F., Curr Opin Gastroenterol. 2010 Oct 1. [Epub ahead of print]
	Role of diet in the development of inflammatory bowel disease. Chapman-Kiddell CA, Davies PS, Gillen L, Radford-Smith GL., Inflamm Bowel Dis. 2010 Jan;16(1):137-51.
	Quality of care in inflammatory bowel disease: a review and discussion. Kappelman MD, Palmer L, Boyle BM, Rubin DT., Inflamm Bowel Dis. 2010 Jan;16(1):125-33.
	Potential for amino acids supplementation during inflammatory bowel diseases. Coëffier M, Marion-Letellier R, Déchelotte P., Inflamm Bowel Dis. 2010 Mar;16(3):518-24.
	Autophagy at the gut interface: mucosal responses to stress and the consequences for inflammatory bowel diseases. Huett A, Xavier RJ., Inflamm Bowel Dis. 2010 Jan;16(1):152-74.
	Need for standardization in population-based quality of life studies: a review ofthe current literature. Hoivik ML, Bernklev T, Moum B., Inflamm Bowel Dis. 2010 Mar;16(3):525-36.
	Review article: chronic viral infection in the anti-tumour necrosis factortherapy era in inflammatory bowel disease. Shale MJ, Seow CH, Coffin CS, Kaplan GG, Panaccione R, Ghosh S., Aliment Pharmacol Ther. 2010 Jan;31(1):20-34.
	An analysis of the placebo effect in Crohn's disease over time. Gallahan WC, Case D, Bloomfeld RS., Aliment Pharmacol Ther. 2010 Jan;31(1):102-7.
	Noninvasive radiologic imaging of the large intestine: a valuable complement tooptical colonoscopy. Pickhardt PJ., Curr Opin Gastroenterol. 2010 Jan;26(1):61-8.
	Review article: influenza A (H1N1) virus in patients with inflammatory boweldisease. Rahier JF, Yazdanpanah Y, Viget N, Travis S, Colombel JF., Aliment Pharmacol Ther. 2010 Jan;31(1):5-10.
	Crohn's disease of the esophagus with esophagobronchial fistula formation: a casereport and review of the literature. Clarke BW, Cassara JE, Morgan DR., Gastrointest Endosc. 2010 Jan;71(1):207-9. Epub 2009 Oct 28.
	Completion mucosectomy for retained rectal mucosa following restorativeproctocolectomy with double-stapled ileal pouch-anal anastomosis. Litzendorf ME, Stucchi AF, Wishnia S, Lightner A, Becker JM., J Gastrointest Surg. 2010 Mar;14(3):562-9.
	Probiotics: progress toward novel therapies for intestinal diseases. Yan F, Polk DB., Curr Opin Gastroenterol. 2010 Mar;26(2):95-101.
	Evolving paradigms in the pathogenesis of IBD. Mayer L., J Gastroenterol. 2010;45(1):9-16. Epub 2009 Dec 4.
	Factors associated with non-adherence to oral medication for inflammatory boweldisease: a systematic review. Jackson CA, Clatworthy J, Robinson A, Horne R., Am J Gastroenterol. 2010 Mar;105(3):525-39. Epub 2009 Dec 8.
	Endorectal advancement flap for cryptoglandular or Crohn's fistula-in-ano. Soltani A, Kaiser AM., Dis Colon Rectum. 2010 Apr;53(4):486-95.
Supplementary evidence:
	Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. Deiteren A, Camilleri M, Burton D, McKinzie S, Rao A, Zinsmeister AR, Dig Dis Sci. 2010 Feb;55(2):384-91
	Errors in the conduct of systematic reviews of pharmacological interventions for irritable bowel syndrome. Ford AC, Guyatt GH, Talley NJ, Moayyedi P, Am J Gastroenterol. 2010 Feb;105(2):280-8
	Testing a biobehavioral model of irritable bowel syndrome. van der Veek PP, Dusseldorp E, van Rood YR, Masclee AA, Eur J Gastroenterol Hepatol. 2010 Apr;22(4):412-9
	Diarrhea-predominant irritable bowel syndrome is associated with diverticular disease: a population-based study. Jung HK, Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Talley NJ, Am J Gastroenterol. 2010 Mar;105(3):652-61
	Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale. Spiegel B, Bolus R, Harris LA, Lucak S, Naliboff B, Esrailian E, Chey WD, Lembo A, Karsan H, Tillisch K, Talley J, Mayer E, Chang L, Aliment Pharmacol Ther. 2009 Dec 1;30(11-12):1159-70
	Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Lee S, Wu J, Ma YL, Tsang A, Guo WJ, Sung J, Aliment Pharmacol Ther. 2009 Sep 15;30(6):643-51
	Low Mannan-binding lectin serum levels are associated with complicated Crohn's disease and reactivity to oligomannan (ASCA). Schoepfer AM, Flogerzi B, Seibold-Schmid B, Schaffer T, Kun JF, Pittet V, Mueller S, Seibold F, Am J Gastroenterol. 2009 Oct;104(10):2508-16