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World Gastroenterology Organisation
World Gastroenterology Organisation
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Celiac Disease

Level: Meta-analyses, Systematic reviews, Practice guidelines: 42 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

Coeliac disease.
Mooney PD, Hadjivassiliou M, Sanders DS., BMJ. 2014 Mar 3;348:g1561. doi: 10.1136/bmj.g1561.
Comments: Review: Adult coeliac disease: estimated prevalence 0,2-1%, should be looked for in unexplained anaemia, weight loss, diarrhoea, or gastrointestinal symptoms, particularly irritable bowel syndrome, and in first degree relatives.

Meta-analysis: deamidated gliadin peptide (DGP) antibody and tissue transglutaminase (tTG) antibody compared as screening tests for coeliac disease.
Lewis NR, Scott BB, Aliment Pharmacol Ther. 2009 Jul 31;


Recognition, assessment, and management of coeliac disease: summary of updated NICE guidance.
Downey L, Houten R, Murch S, Longson D; Guideline Development Group., BMJ. 2015 Sep 2;351:h4513. doi: 10.1136/bmj.h4513. No abstract available.

Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants.
Romanos J, Rosén A, Kumar V, Trynka G, Franke L, Szperl A, Gutierrez-Achury J, van Diemen CC, Kanninga R, Jankipersadsing SA, Steck A, Eisenbarth G, van Heel DA, Cukrowska B, Bruno V, Mazzilli MC, Núñez C, Bilbao JR, Mearin ML, Barisani D, Rewers M, Norris JM, Ivarsson A, Boezen HM, Liu E, Wijmenga C; PreventCD Group., Gut. 2014 Mar;63(3):415-22. doi: 10.1136/gutjnl-2012-304110. Epub 2013 May 23.

Comments: The heterodimer, HLA-DQ2 and DQ8, is a major risk factor for celiac but ~40% of the population carry these alleles and the majority never develop CD. Adding 57 non-HLA variants, the area under the ROC curve reached 0.854 vs 0.823 for HLA only, and 11.1% of individuals were reclassified to a more accurate risk group.

Kinetics of the histological, serological and symptomatic responses to glutenchallenge in adults with coeliac disease.
Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP., Gut. 2013 Jul;62(7):996-1004. doi: 10.1136/gutjnl-2012-302196. Epub 2012 May 22.
Comments: 14 day GC at = 3 g of gluten/day induces histological and serological changes in the majority of adults with coeliac disease.

A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge.
Leffler DA, Kelly CP, Abdallah HZ, Colatrella AM, Harris LA, Leon F, Arterburn LA, Paterson BM, Lan ZH, Murray JA., Am J Gastroenterol. 2012 Oct;107(10):1554-62. doi: 10.1038/ajg.2012.211. Epub2012 Jul 24.

The Oslo definitions for coeliac disease and related terms.
Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PH, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, Murray JA, Sanders DS, Walker MM, Zingone F, Ciacci C., Gut. 2013 Jan;62(1):43-52. doi: 10.1136/gutjnl-2011-301346. Epub 2012 Feb 16.

Probiotics for the prevention of Clostridium difficile-associated diarrhea inadults and children.
Goldenberg JZ, Ma SS, Saxton JD, Martzen MR, Vandvik PO, Thorlund K, Guyatt GH, Johnston BC., Cochrane Database Syst Rev. 2013 May 31;5:CD006095. doi:10.1002/14651858.CD006095.pub3.

An update on the use and investigation of probiotics in health and disease.
Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM, Mayer EA., Gut. 2013 May;62(5):787-96. doi: 10.1136/gutjnl-2012-302504. Epub 2013 Mar 8.

Where are all those patients with Celiac disease?
Green PH, Am J Gastroenterol. 2007 Jul;102(7):1461-3 - PubTypeList: Comment, Editorial, Review

Systematic review: the use of serology to exclude or diagnose coeliac disease (a comparison of the endomysial and tissue transglutaminase antibody tests).
Lewis NR, Scott BB, Aliment Pharmacol Ther. 2006 Jul 1;24(1):47-54 - PubTypeList: Journal Article, Review

Recent advances in coeliac disease.
van Heel DA, West J, Gut. 2006 Jul;55(7):1037-46 - PubTypeList: Journal Article, Review

Association of celiac disease and intestinal lymphomas and other cancers.
Catassi C, Bearzi I, Holmes GK, Gastroenterology. 2005 Apr;128(4 Suppl 1):S79-86 - PubTypeList: Journal Article, Review

The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review.
Dubé C, Rostom A, Sy R, Cranney A, Saloojee N, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, Macneil J, Mack D, Patel D, Moher D, Gastroenterology. 2005 Apr;128(4 Suppl 1):S57-67 - PubTypeList: Journal Article, Review

Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta-analysis.
Sainsbury A, Sanders DS, Ford AC., Clin Gastroenterol Hepatol. 2013 Apr;11(4):359-65.e1. doi:10.1016/j.cgh.2012.11.033. Epub 2012 Dec 13.

Comments: IBS-type symptoms occur frequently in patients with Celiac disease


Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis.
Singh P, Arora S, Lal S, Strand TA, Makharia GK., Am J Gastroenterol. 2015 Nov;110(11):1539-48. doi: 10.1038/ajg.2015.296. Epub 2015 Sep 29. Review.

No effects of gluten in patients with self-reported non-celiac gluten sensitivityafter dietary reduction of fermentable, poorly absorbed, short-chaincarbohydrates.
Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR., Gastroenterology. 2013 Aug;145(2):320-8.e1-3. doi: 10.1053/j.gastro.2013.04.051. Epub 2013 May 4.

Comments: A placebo-controlled, cross-over rechallenge study showing no effects of gluten in self-reported non-celiac gluten sensitivity.

Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlledchallenge: exploring a new clinical entity.
Carroccio A, Mansueto P, Iacono G, Soresi M, D'Alcamo A, Cavataio F, Brusca I,Florena AM, Ambrosiano G, Seidita A, Pirrone G, Rini GB., Am J Gastroenterol. 2012 Dec;107(12):1898-906; quiz 1907. doi:10.1038/ajg.2012.236. Epub 2012 Jul 24.

Sex and racial disparities in duodenal biopsy to evaluate for celiac disease.
Lebwohl B, Tennyson CA, Holub JL, Lieberman DA, Neugut AI, Green PH., Gastrointest Endosc. 2012 Oct;76(4):779-85. doi: 10.1016/j.gie.2012.05.011. Epub 2012 Jun 23.

Determinants of endomysial antibody status in untreated coeliac disease.
Boger CP, Thomas PW, Nicholas DS, Surgenor SL, Snook JA, Eur J Gastroenterol Hepatol. 2007 Oct;19(10):890-5 - PubTypeList: Journal Article, Review

Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease.
Matysiak-Budnik T, Candalh C, Cellier C, Dugave C, Namane A, Vidal-Martinez T, Cerf-Bensussan N, Heyman M, Gastroenterology. 2005 Sep;129(3):786-96 - PubTypeList: Journal Article, Review

Collagenous mucosal inflammatory diseases of the gastrointestinal tract.
Freeman HJ, Gastroenterology. 2005 Jul;129(1):338-50 - PubTypeList: Journal Article, Review

Neurologic presentation of celiac disease.
Bushara KO, Gastroenterology. 2005 Apr;128(4 Suppl 1):S92-7 - PubTypeList: Journal Article, Review

What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations?
Hill ID, Gastroenterology. 2005 Apr;128(4 Suppl 1):S25-32 - PubTypeList: Journal Article, Review

Dietary guidelines and implementation for celiac disease.
Kupper C, Gastroenterology. 2005 Apr;128(4 Suppl 1):S121-7 - PubTypeList: Journal Article, Review

Should adults be screened for celiac disease? What are the benefits and harms of screening?
Collin P, Gastroenterology. 2005 Apr;128(4 Suppl 1):S104-8 - PubTypeList: Journal Article, Review

Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, Hoffenberg EJ, Horvath K, Murray JA, Pivor M, Seidman EG, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, J Pediatr Gastroenterol Nutr. 2005 Jan;40(1):1-19 - PubTypeList: Guideline, Journal Article, Practice Guideline


Where's the evidence for gluten sensitivity?
Elli L., BMJ. 2012 Nov 2;345:e7360. doi: 10.1136/bmj.e7360.


Systematic review: The evidence base for long-term management of coeliac disease.
Haines ML, Anderson RP, Gibson PR, Aliment Pharmacol Ther. 2008 Nov 1;28(9):1042-66 - PubTypeList: Journal Article, Review


Should coeliac sufferers be allowed their oats?
Ellis HJ, Ciclitira PJ, Eur J Gastroenterol Hepatol. 2008 Jun;20(6):492-3 - PubTypeList: Comment, Journal Article, Review


Affective and psychiatric disorders in celiac disease.
Addolorato G, Leggio L, D'Angelo C, Mirijello A, Ferrulli A, Cardone S, Vonghia L, Abenavoli L, Leso V, Nesci A, Piano S, Capristo E, Gasbarrini G, Dig Dis. 2008;26(2):140-8 - PubTypeList: Journal Article, Review


Metabolic and nutritional features in adult celiac patients.
Malandrino N, Capristo E, Farnetti S, Leggio L, Abenavoli L, Addolorato G, Gasbarrini G, Dig Dis. 2008;26(2):128-33 - PubTypeList: Journal Article, Review


Review article: future research on coeliac disease - a position report from the European multistakeholder platform on coeliac disease (CDEUSSA).
Troncone R, Ivarsson A, Szajewska H, Mearin ML, Members of European Multistakeholder Platform on CD (CDEUSSA), Aliment Pharmacol Ther. 2008 Jun 1;27(11):1030-43 - PubTypeList: Journal Article, Review


Systematic review: tolerable amount of gluten for people with coeliac disease.
Akobeng AK, Thomas AG, Aliment Pharmacol Ther. 2008 Jun 1;27(11):1044-52 - PubTypeList: Journal Article, Review


Genetic background of celiac disease and its clinical implications.
Wolters VM, Wijmenga C, Am J Gastroenterol. 2008 Jan;103(1):190-5 - PubTypeList: Journal Article, Review


Can oats be taken in a gluten-free diet? A systematic review.
Garsed K, Scott BB, Scand J Gastroenterol. 2007 Feb;42(2):171-8 - PubTypeList: Journal Article, Review


American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease.
Rostom A, Murray JA, Kagnoff MF, Gastroenterology. 2006 Dec;131(6):1981-2002 - PubTypeList: Journal Article, Review


AGA Institute Medical Position Statement on the Diagnosis and Management of Celiac Disease.
AGA Institute, Gastroenterology. 2006 Dec;131(6):1977-80 - PubTypeList: Journal Article, Practice Guideline


Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease.
Hischenhuber C, Crevel R, Jarry B, Mäki M, Moneret-Vautrin DA, Romano A, Troncone R, Ward R, Aliment Pharmacol Ther. 2006 Mar 1;23(5):559-75 - PubTypeList: Journal Article, Review


Should all children be screened for celiac disease?
Hoffenberg EJ, Gastroenterology. 2005 Apr;128(4 Suppl 1):S98-103 - PubTypeList: Journal Article, Review


Skin manifestations of celiac disease.
Zone JJ, Gastroenterology. 2005 Apr;128(4 Suppl 1):S87-91 - PubTypeList: Journal Article, Review


Clinical presentation of celiac disease in the pediatric population.
Fasano A, Gastroenterology. 2005 Apr;128(4 Suppl 1):S68-73 - PubTypeList: Journal Article, Review


Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?
Liu E, Rewers M, Eisenbarth GS, Gastroenterology. 2005 Apr;128(4 Suppl 1):S33-7 - PubTypeList: Journal Article, Review


Clinical features and diagnosis of celiac disease.
Dewar DH, Ciclitira PJ, Gastroenterology. 2005 Apr;128(4 Suppl 1):S19-24 - PubTypeList: Journal Article, Review