MENU
WGO
Back to Top
World Gastroenterology Organisation
World Gastroenterology Organisation
Follow
WGO: Facebook WGO: Twitter
Share

Colectoral Cancer Screening and Surveillance

Level: Meta-analyses, Systematic reviews, Practice guidelines: 138 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

   

American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome.
Rubenstein JH, Enns R, Heidelbaugh J, Barkun A; Clinical Guidelines Committee., Gastroenterology. 2015 Sep;149(3):777-82; quiz e16-7. doi: 10.1053/j.gastro.2015.07.036. Epub 2015 Jul 27. Review. No abstract available.

   

American Gastroenterological Association Technical Review on the Diagnosis and Management of Lynch Syndrome.
Ladabaum U, Ford JM, Martel M, Barkun AN., Gastroenterology. 2015 Sep;149(3):783-813.e20. doi: 10.1053/j.gastro.2015.07.037. Epub 2015 Jul 27. Review. No abstract available.

Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics.
McGill SK, Evangelou E, Ioannidis JP, Soetikno RM, Kaltenbach T., Gut. 2013 Apr 17. [Epub ahead of print]

Regorafenib monotherapy for previously treated metastatic colorectal cancer(CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3trial.
Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, GoldbergRM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D; CORRECT Study Group., Lancet. 2013 Jan 26;381(9863):303-12. doi: 10.1016/S0140-6736(12)61900-X. Epub2012 Nov 22.

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.
Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW, Mehta Z., Lancet. 2012 Apr 28;379(9826):1591-601. doi: 10.1016/S0140-6736(12)60209-8. Epub 2012 Mar 21.

Comments: All five randomised trials of daily aspirin (≥75 mg daily) versus control for the prevention of vascular events in the UK were analysed. Of 17,285 participants, 987 developed a new solid cancer during the mean 6-5 yrs. Aspirin reduced the overall risk of fatal adenocarcinoma (HR 0-65, p=0-0002), particularly in those without metastasis at diagnosis (HR 0-50) but not of other fatal cancers, and particularly in colorectal cancer (HR 0-26). The reduction of cancer with distant metastasis (all cancers, hazard ratio [HR] 0-64) was mainly due to a reduction in proportion of adenocarcinomas that had metastatic versus local disease (odds ratio 0-52, p=0-0006). A low-dose, slow-release formulation was as effective as higher doses.

Screening for colorectal cancer: a guidance statement from the American Collegeo f Physicians.
Qaseem A, Denberg TD, Hopkins RH Jr, Humphrey LL, Levine J, Sweet DE, Shekelle P;Clinical Guidelines Committee of the American College of Physicians., Ann Intern Med. 2012 Mar 6;156(5):378-86. doi:10.1059/0003-4819-156-5-201203060-00010.

Comments: Guidance statement from the American College of Physicians.1: individualized assessment of risk for colorectal cancer is needed in all adults 2: starting at 50 years and in high-risk adults at 40 years, 3: by a stool-based test, flexible sigmoidoscopy, or optical colonoscopy, but always colonoscopy in high risk. patients. 4:Screening can be stopped in adults over 75 yrs or in adults with a life expectancy of less than 10 years.

Next-generation stool DNA test accurately detects colorectal cancer and large adenomas.
Ahlquist DA, Zou H, Domanico M, Mahoney DW, Yab TC, Taylor WR, Butz ML, ThibodeauSN, Rabeneck L, Paszat LF, Kinzler KW, Vogelstein B, Bjerregaard NC, Laurberg S, Sørensen HT, Berger BM, Lidgard GP., Gastroenterology. 2012 Feb;142(2):248-56; quiz e25-6. doi:10.1053/j.gastro.2011.10.031. Epub 2011 Nov 4.

Comments: A next-generation stool DNA test might accurately detect colorectal neoplasms and was used in a case-control study of archived stool samples from 252 patients with colorectal cancer, 133 with adenomas = 1 cm, and 293 individuals with normal colonoscopy. The sDNA test detects 4 methylated genes, a mutant form of KRAS, and the a-actin gene (as a reference value), it also quantifies hemoglobin. The sDNA test identified 85% of patients with CRC and 54% of patients with adenomas =1 cm with 90% specificity. Detection rates increased with adenoma size: 54% = 1 cm; 92% > 4 cm.

Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trial.
Rastogi A, Bansal A, Rao DS, Gupta N, Wani SB, Shipe T, Gaddam S, Singh V, SharmaP., Gut. 2012 Mar;61(3):402-8. doi: 10.1136/gutjnl-2011-300187. Epub 2011 Oct 13.

Comments: Cap-assisted colonoscopy (CAC) uses a small plastic transparent cap attached to the tip of the colonoscope that can depress and flatten colonic folds and thus improve visualisation of their proximal aspects. This prospective randomised controlled trial enrolled 420 subjects was to compare CAC with standard colonoscopy (high-definition white light). The proportion of subjects with at least one adenoma was 13% higher with CAC compared to SC (69% vs 56%, p=0.009) and a higher number of adenomas per subject (2.3 vs 1.4, p<0.001) was detected. The caecal intubation time was also shorter with CAC (3.29 min vs 3.98 min, p<0.001). The caecal intubation rates were similar in the two groups (99% vs 98%, p=0.37).

Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening.
Quintero E, Castells A, Bujanda L, Cubiella J, Salas D, Lanas �, Andreu M,Carballo F, Morillas JD, Hernández C, Jover R, Montalvo I, Arenas J, Laredo E,Hernández V, Iglesias F, Cid E, Zubizarreta R, Sala T, Ponce M, Andrés M, Teruel G, Peris A, Roncales MP, Polo-Tomás M, Bessa X, Ferrer-Armengou O, Grau J,Serradesanferm A, Ono A, Cruzado J, Pérez-Riquelme F, Alonso-Abreu I, de laVega-Prieto M, Reyes-Melian JM, Cacho G, Díaz-Tasende J, Herreros-de-Tejada A,Poves C, Santander C, González-Navarro A; COLONPREV Study Investigators., N Engl J Med. 2012 Feb 23;366(8):697-706. doi: 10.1056/NEJMoa1108895.

Comments: Colonoscopy and fecal immunochemical testing (FIT) are accepted strategies for colorectal-cancer screening in the average-risk population.Compariosn of colonoscopy in 26,703 subjects with FIT every 2 years in 26,599 asymptomatic subjects aged 50-69 yrs. Screening by FIT was more adhered to. At baseline screening, colorectal cancer was detected similarly in the two groups, but more adenomas were identified in the colonoscopy group.

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.
Din FV, Theodoratou E, Farrington SM, Tenesa A, Barnetson RA, Cetnarskyj R, StarkL, Porteous ME, Campbell H, Dunlop MG., Gut. 2010 Dec;59(12):1670-9. Epub 2010 Sep 15.

Editorial: It's time to make organized colorectal cancer screening convenient and easy for patients.
Levin TR, Am J Gastroenterol. 2009 Apr;104(4):939-41 Cat: Comment, Editorial

Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.
Winawer SJ, Zauber AG, Fletcher RH, Stillman JS, O'Brien MJ, Levin B, Smith RA, Lieberman DA, Burt RW, Levin TR, Bond JH, Brooks D, Byers T, Hyman N, Kirk L, Thorson A, Simmang C, Johnson D, Rex DK, US Multi-Society Task Force on Colorectal Cancer, American Cancer Society, Gastroenterology. 2006 May;130(6):1872-85 - PubTypeList: Journal Article, Practice Guideline, Review

  

Lynch Syndrome: AGA Patient Guideline Summary.
American Gastroenterological Association., Gastroenterology. 2015 Sep;149(3):814-5. doi: 10.1053/j.gastro.2015.07.020. Epub 2015 Jul 26. No abstract available.

  

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis.
Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y, Xia D, Yang J, Cai J, Wu Y., Gut. 2015 Sep;64(9):1419-25. doi: 10.1136/gutjnl-2014-308260. Epub 2014 Sep 19. Review.

  

Serrated polyps and the risk of synchronous colorectal advanced neoplasia: a systematic review and meta-analysis.
Gao Q, Tsoi KK, Hirai HW, Wong MC, Chan FK, Wu JC, Lau JY, Sung JJ, Ng SC., Am J Gastroenterol. 2015 Apr;110(4):501-9; quiz 510. doi: 10.1038/ajg.2015.49. Epub 2015 Mar 10. Review.
 

  

An updated Asia Pacific Consensus Recommendations on colorectal cancer screening.
Sung JJ, Ng SC, Chan FK, Chiu HM, Kim HS, Matsuda T, Ng SS, Lau JY, Zheng S, Adler S, Reddy N, Yeoh KG, Tsoi KK, Ching JY, Kuipers EJ, Rabeneck L, Young GP, Steele RJ, Lieberman D, Goh KL; Asia Pacific Working Group., Gut. 2015 Jan;64(1):121-32. doi: 10.1136/gutjnl-2013-306503. Epub 2014 Mar 19.
Comments: Screening strategy in the Asian-Pacific region

Tracking the molecular features of nonpolypoid colorectal neoplasms: a systematic review and meta-analysis.
Voorham QJ, Rondagh EJ, Knol DL, van Engeland M, Carvalho B, Meijer GA,Sanduleanu S., Am J Gastroenterol. 2013 Jul;108(7):1042-56. doi: 10.1038/ajg.2013.126. Epub 2013 May 7.

Comments: Nonpolypoid colorectal neoplasms: NP-CRNs are molecularly different from protruded CRNs.

An update on the use and investigation of probiotics in health and disease.
Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM,Mayer EA., Gut. 2013 May;62(5):787-96. doi: 10.1136/gutjnl-2012-302504. Epub 2013 Mar 8.

Comments: Until now, no studies have been conducted that can causally link clinical improvements to probiotic-induced microbiota changes

Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial.
Halligan S, Wooldrage K, Dadswell E, Kralj-Hans I, von Wagner C, Edwards R, YaoG, Kay C, Burling D, Faiz O, Teare J, Lilford RJ, Morton D, Wardle J, Atkin W;SIGGAR investigators., Lancet. 2013 Apr 6;381(9873):1185-93. doi: 10.1016/S0140-6736(12)62124-2. Epub 2013 Feb 14.

Comments: CompTomographyC is a more sensitive test than Barium Enema to detect CRC

Revised guidelines for the clinical management of Lynch syndrome (HNPCC):recommendations by a group of European experts.
Vasen HF, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, Bernstein I,Bertario L, Burn J, Capella G, Colas C, Engel C, Frayling IM, Genuardi M,Heinimann K, Hes FJ, Hodgson SV, Karagiannis JA, Lalloo F, Lindblom A, MecklinJP, Møller P, Myrhoj T, Nagengast FM, Parc Y, Ponz de Leon M, Renkonen-SinisaloL, Sampson JR, Stormorken A, Sijmons RH, Tejpar S, Thomas HJ, Rahner N, WijnenJT, Järvinen HJ, Möslein G; Mallorca group., Gut. 2013 Jun;62(6):812-23. doi: 10.1136/gutjnl-2012-304356. Epub 2013 Feb 13.

Comments: Revised guidelines for the clinical management of Lynch syndrome (HNPCC)

A population-based comparison of immunochemical fecal occult blood tests for colorectal cancer screening.
Raginel T, Puvinel J, Ferrand O, Bouvier V, Levillain R, Ruiz A, Lantieri O,Launoy G, Guittet L., Gastroenterology. 2013 May;144(5):918-25. doi: 10.1053/j.gastro.2013.01.042. Epub 2013 Feb 1.

Comments: Faecal screening with Magstream, OC Sensor and Hemoccult II guaiac test: true-positive rates for Magstream and OC Sensor FITs were 0.65% and 0.90% resp, and 0.42% for Hemoccult II. OC Sensor FIT has the greater accuracy.

Timing of hepatectomy in resectable synchronous colorectal liver metastases(SCRLM): Simultaneous or delayed?
Yin Z, Liu C, Chen Y, Bai Y, Shang C, Yin R, Yin D, Wang J., Hepatology. 2013 Jun;57(6):2346-57. doi: 10.1002/hep.26283.

Comments: Meta-analysis: Simultaneous resection by partial hepatectomy in pts with colorectal liver metastases is as efficient as a delayed procedure for long-term survival

Risk of cancer in cases of suspected lynch syndrome without germline mutation.
Rodríguez-Soler M, Pérez-Carbonell L, Guarinos C, Zapater P, Castillejo A,Barberá VM, Juárez M, Bessa X, Xicola RM, Clofent J, Bujanda L, Balaguer F, Reñé JM, de-Castro L, Marín-Gabriel JC, Lanas A, Cubiella J, Nicolás-Pérez D,Brea-Fernández A, Castellví-Bel S, Alenda C, Ruiz-Ponte C, Carracedo A, Castells A, Andreu M, Llor X, Soto JL, Payá A, Jover R., Gastroenterology. 2013 May;144(5):926-932.e1; quiz e13-4. doi:10.1053/j.gastro.2013.01.044. Epub 2013 Jan 24.

Comments: The risk of cancer in families with Lynch-like syndrome is lower than that of families with Lynch syndrome but higher than that of families with sporadic CRC

Identification of Genetic Susceptibility Loci for Colorectal Tumors in aGenome-Wide Meta-analysis.
Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI,Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G,Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV,Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, GogartenSM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M,Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, LemireM, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD,Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO,Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, ZengYX, Zhang B, Zheng W, Hsu L; Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium., Gastroenterology. 2013 Apr;144(4):799-807.e24. doi: 10.1053/j.gastro.2012.12.020. Epub 2012 Dec 22.

Offering people a choice for colorectal cancer screening.
Senore C, Ederle A, Benazzato L, Arrigoni A, Silvani M, Fantin A, Fracchia M,Armaroli P, Segnan N., Gut. 2013 May;62(5):735-40. doi: 10.1136/gutjnl-2011-301013. Epub 2012 Mar 22.

Comments: A strategy involving the sequential offer of FS and FIT is a feasible and efficient approach

Identification of Genetic Susceptibility Loci for Colorectal Tumors in aGenome-Wide Meta-analysis.
Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI,Bézieau S, Brenner H, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Casey G,Chan AT, Chang-Claude J, Chanock SJ, Chen LS, Coetzee GA, Coetzee SG, Conti DV,Curtis KR, Duggan D, Edwards T, Fuchs CS, Gallinger S, Giovannucci EL, GogartenSM, Gruber SB, Haile RW, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M,Hopper JL, Hudson TJ, Hunter DJ, Jackson RD, Jee SH, Jenkins MA, Jia WH, Kolonel LN, Kooperberg C, Küry S, Lacroix AZ, Laurie CC, Laurie CA, Le Marchand L, LemireM, Levine D, Lindor NM, Liu Y, Ma J, Makar KW, Matsuo K, Newcomb PA, Potter JD,Prentice RL, Qu C, Rohan T, Rosse SA, Schoen RE, Seminara D, Shrubsole M, Shu XO,Slattery ML, Taverna D, Thibodeau SN, Ulrich CM, White E, Xiang Y, Zanke BW, ZengYX, Zhang B, Zheng W, Hsu L; Colon Cancer Family Registry and the Genetics andEpidemiology of Colorectal Cancer Consortium., Gastroenterology. 2013 Apr;144(4):799-807.e24. doi: 10.1053/j.gastro.2012.12.020. Epub 2012 Dec 22.

Comments: In a large GWAS, polymorphisms close to nucleic acid binding protein 1, in laminin gamma 1, cyclin D2 ( involved in DNA repair) and T-box 3 (a target of Wnt signaling to β-catenin) are associated with colorectal tumor risk

Pre-operative chemoradiation for non-metastatic locally advanced rectal cancer.
McCarthy K, Pearson K, Fulton R, Hewitt J., Cochrane Database Syst Rev. 2012 Dec 12;12:CD008368. doi:10.1002/14651858.CD008368.pub2.

Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial.
Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M,Manson JE, Glynn RJ, Buring JE., JAMA. 2012 Nov 14;308(18):1871-80.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Quality assurance in endoscopy in colorectal cancerscreening and diagnosis.
Valori R, Rey JF, Atkin WS, Bretthauer M, Senore C, Hoff G, Kuipers EJ,Altenhofen L, Lambert R, Minoli G; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE88-105. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening anddiagnosis. First Edition--Faecal occult blood testing.
Halloran SP, Launoy G, Zappa M; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE65-87. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Evaluation and interpretation of screening outcomes.
Moss S, Ancelle-Park R, Brenner H; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE49-64. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Organisation.
Malila N, Senore C, Armaroli P; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE31-48. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Communication.
Austoker J, Giordano L, Hewitson P, Villain P; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE164-85. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Colonoscopic surveillance following adenoma removal.
Atkin WS, Valori R, Kuipers EJ, Hoff G, Senore C, Segnan N, Jover R, Schmiegel W,Lambert R, Pox C; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE151-63. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Introduction.
Lansdorp-Vogelaar I, von Karsa L; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE15-30. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Management of lesions detected in colorectal cancers creening.
Steele RJ, Pox C, Kuipers EJ, Minoli G, Lambert R; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE140-50. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Annotations of colorectal lesions.
Vieth M, Quirke P, Lambert R, von Karsa L, Risio M; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE131-9. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Quality assurance in pathology in colorectal cancer screening and diagnosis.
Quirke P, Risio M, Lambert R, von Karsa L, Vieth M; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE116-30. Epub 2012 Sep 25.

European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Professional requirements and training.
Steele RJ, Rey JF, Lambert R; International Agency for Research on Cancer., Endoscopy. 2012 Sep;44 Suppl 3:SE106-15. Epub 2012 Sep 25.

Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study.
Pohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR, Levy LC,Toor A, Mackenzie TA, Rosch T, Robertson DJ., Gastroenterology. 2013 Jan;144(1):74-80.e1. doi: 10.1053/j.gastro.2012.09.043. Epub 2012 Sep 25.

Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE).
Rembacken B, Hassan C, Riemann JF, Chilton A, Rutter M, Dumonceau JM, Omar M, Ponchon T., Endoscopy. 2012 Oct;44(10):957-68. doi: 10.1055/s-0032-1325686. Epub 2012 Sep 17.
Comments: no abstract

Immunochemical fecal occult blood testing is equally sensitive for proximal and distal advanced neoplasia.
de Wijkerslooth TR, Stoop EM, Bossuyt PM, Meijer GA, van Ballegooijen M, van RoonAH, Stegeman I, Kraaijenhagen RA, Fockens P, van Leerdam ME, Dekker E, KuipersEJ., Am J Gastroenterol. 2012 Oct;107(10):1570-8. doi: 10.1038/ajg.2012.249. Epub 2012 Jul 31.

Comparison of the clinical prediction model PREMM(1,2,6) and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer.
Kastrinos F, Steyerberg EW, Balmaña J, Mercado R, Gallinger S, Haile R, Casey G, Hopper JL, LeMarchand L, Lindor NM, Newcomb PA, Thibodeau SN, Syngal S; ColonCancer Family Registry., Gut. 2013 Feb;62(2):272-9. doi: 10.1136/gutjnl-2011-301265. Epub 2012 Feb 16.

Interval cancers after colonoscopy-insights and recommendations.
Sanduleanu S, Masclee AM, Meijer GA., Nat Rev Gastroenterol Hepatol. 2012 Sep;9(9):550-4. doi:10.1038/nrgastro.2012.136. Epub 2012 Aug 21.

Comments: Interval cancers may account for up to 9% of all CRCs. There are patient-dependent factors such as Inadequate bowel preparation, co-morbidity or diverticulosis rendering colonoscopic examination challenging, as well as endoscopist-dependent factors (having less experience). With regard to the biology of interval CRCs little scientific evidence is available. Nonpolypoid neoplasms and some subtypes of serrated lesions with a preferential location in the proximal colon, for which resection is the preferred therapeutic method rather than standard polypectomy.

Histamine type 2 receptor antagonists as adjuvant treatment for resected colorectal cancer.
Deva S, Jameson M., Cochrane Database Syst Rev. 2012 Aug 15;8:CD007814. doi:10.1002/14651858.CD007814.pub2.

Comments: The rationale to investigate a probale effect of adjuvant antihistamines on resected colorectal cancer is based on improved immune surveillance (by increasing tumour infiltrating lymphocytes), inhibition of a direct proliferative effect of histamine as a growth factor and by inhibiting endothelial expression of E-selectin (favouring metastatic spread). Analysis of the five cimetidine trials (n = 421) revealed a statistically significant improvement in overall survival (HR 0.53; 95% CI 0.32 to 0.87).

Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study.
Henderson TO, Oeffinger KC, Whitton J, Leisenring W, Neglia J, Meadows A, Crotty C, Rubin DT, Diller L, Inskip P, Smith SA, Stovall M, Constine LS, Hammond S, Armstrong GT, Robison LL, Nathan PC., Ann Intern Med. 2012 Jun 5;156(11):757-66, W-260. doi:10.1059/0003-4819-156-11-201206050-00002.

Comments: Childhood cancer survivors develop GI cancer more frequently and at a younger age; 14 358 survivors of cancer diagnosed when younger than 21 years of age who survived for 5 or more years were studied. The risk for new GI neoplasm was 4.6-fold higher and for colorectal cancer 4.2 fold. The highest risk was associated with abdominal radiation (SIR, 11.2), to high-dose procarbazine (RR 3.2) and platinum drugs (RR 7.6). Surveillance is thus recommended.

Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.
Schoen RE, Pinsky PF, Weissfeld JL, Yokochi LA, Church T, Laiyemo AO, BresalierR, Andriole GL, Buys SS, Crawford ED, Fouad MN, Isaacs C, Johnson CC, Reding DJ, O'Brien B, Carrick DM, Wright P, Riley TL, Purdue MP, Izmirlian G, Kramer BS,Miller AB, Gohagan JK, Prorok PC, Berg CD; PLCO Project Team., N Engl J Med. 2012 Jun 21;366(25):2345-57. doi: 10.1056/NEJMoa1114635. Epub 2012 May 21.

Comments: From 1993 through 2001, we randomly assigned 154,900 men and women 55 to 74 yrs of age either to screening with flexible sigmoidoscopy (at 3 or 5 yrs interval) or to usual care.The incidence of colorectal cancer after a median of 11.9 yrs was 11.9 cases per 10,000 person-years (intervention group) compared with 15.2 cases (21% reduction). Mortality from distal colorectal cancer was reduced by 50% (87 deaths vs. 175), mortality from proximal colorectal cancer was unaffected (143 and 147 deaths)

Cancer risks for relatives of patients with serrated polyposis.
Win AK, Walters RJ, Buchanan DD, Jenkins MA, Sweet K, Frankel WL, de la Chapelle A, McKeone DM, Walsh MD, Clendenning M, Pearson SA, Pavluk E, Nagler B, HopperJL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Field M, Greening S, Gallinger S, Aronson M, Perrier R, Woods MO,Green JS, Walker N, Rosty C, Parry S, Young JP., Am J Gastroenterol. 2012 May;107(5):770-8. doi: 10.1038/ajg.2012.52. Epub 2012 Apr 24.

Comments: Serrated (hyperplastic) polyposis) is characterized by multiple polyps with serrated architecture in the colorectum, and is known to predispose to colorectal and possibly extracolonic cancers, The present study demonstrates that relatives of serrated polyposis patients are also at increased risk of colorectal and pancreatic cancer.

Clinical practice guidelines: quality of colonoscopy in colorectal cancer screening.
Jover R, Herráiz M, Alarcón O, Brullet E, Bujanda L, Bustamante M, Campo R,Carreño R, Castells A, Cubiella J, García-Iglesias P, Hervás AJ, Menchén P, OnoA, Panadés A, Parra-Blanco A, Pellisé M, Ponce M, Quintero E, Reñé JM, Sánchezdel Río A, Seoane A, Serradesanferm A, Soriano Izquierdo A, Vázquez Sequeiros E; Spanish Society of Gastroenterology; Spanish Society of GastrointestinalEndoscopy Working Group., Endoscopy. 2012 Apr;44(4):444-51. doi: 10.1055/s-0032-1306690. Epub 2012 Mar 21.

Comments: Important paper documenting Guide Lines for colonoscopy

The incidence of 30-day adverse events after colonoscopy among outpatients in the Netherlands.
de Jonge V, Sint Nicolaas J, van Baalen O, Brouwer JT, Stolk MF, Tang TJ, vanTilburg AJ, van Leerdam ME, Kuipers EJ; SCoPE consortium., Am J Gastroenterol. 2012 Jun;107(6):878-84. doi: 10.1038/ajg.2012.40. Epub 2012 Mar 6.

Comments: Assessment of adverse events of coloscopy procedure in 1,144 patients: 1,3% major adverse events; mino in 32 %. More frequent in Female gender, age <50 years, and in colorectal cancer screening/surveillance, and fellow-endoscopy

Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies.
Jess T, Rungoe C, Peyrin-Biroulet L., Clin Gastroenterol Hepatol. 2012 Jun;10(6):639-45. doi:10.1016/j.cgh.2012.01.010. Epub 2012 Jan 28.

Comments: Meta-analysis of 8 population-based cohort studies to determine the risk of CRC in patients with UC. An average of 1.6% of patients with UC was diagnosed with CRC during 14 years of follow-up. UC increases the risk of CRC 2.4-fold. Male sex, young age at diagnosis with UC, and extensive colitis increase the risk.

Colonic mucosal biopsies obtained during confocal endomicroscopy are pre-stained with fluorescein in vivo and are suitable for histologic evaluation.
Coron E, Mosnier JF, Ahluwalia A, Le Rhun M, Galmiche JP, Tarnawski AS, Matysiak-Budnik T., Endoscopy. 2012 Feb;44(2):148-53. doi: 10.1055/s-0031-1291534. Epub 2012 Jan 23.

Comments: This study shows that standard colonic biopsies obtained during Confocal laser endomicroscopy retain fluorescein, show excellent delineation of mucosal structures without additional staining and allow the evaluation of mucosal microvasculature and vascular permeability, and are suitable for immunostaining.

Efficacy and safety of endoscopic submucosal dissection for colorectal neoplasia: a systematic review.
Repici A, Hassan C, De Paula Pessoa D, Pagano N, Arezzo A, Zullo A, Lorenzetti R, Marmo R., Endoscopy. 2012 Feb;44(2):137-50. doi: 10.1055/s-0031-1291448. Epub 2012 Jan 23.

Comments: Overview of 22 studies on on 2841 treated lesions: Since endoscopic mucosal resection carries a high risk of recurrence, endoscopic submucosal dissection was studied: it appears to be an extremely effective technique to achieve R0 resection of large colorectal lesions

Body mass index increases risk for colorectal adenomas based on meta-analysis.
Ben Q, An W, Jiang Y, Zhan X, Du Y, Cai QC, Gao J, Li Z., Gastroenterology. 2012 Apr;142(4):762-72. doi: 10.1053/j.gastro.2011.12.050. Epub 2012 Jan 11.

Comments: A meta-analysis of 36 independent studies of 29,860 incident cases of ColoRectal demontrates that increased BMI increases the risk for colon but not rectal adenoma. Unlike colorectal cancer, there is no sex difference in the relationship between increased BMI and risk of CRA.

Lower risk of advanced neoplasia among patients with a previous negative result from a fecal test for colorectal cancer.
Denters MJ, Deutekom M, Bossuyt PM, Stroobants AK, Fockens P, Dekker E., Gastroenterology. 2012 Mar;142(3):497-504. doi: 10.1053/j.gastro.2011.11.024. Epub 2011 Nov 19.

Comments: Average-risk persons (50 to 74 years old) were randomly assigned to groups that received the guaiac FOBT or FIT in the first round in 2006. Results: 2.8 and 8.1% positive tests respect. In the second round in 2008, only FIT was used. The positivity rate and PPV for advanced neoplasia and CRC were compared between second-round participants with a previous negative test result (FIT after guaiac). The rate of positive results from FIT was 7.4% in the FIT-after-FIT group, compared with 8.1% in the first-round FIT group (P = .34). A significant decrease was observed in the PPV for advanced neoplasia between the first and second round from 55% (132/239) to 44% (112/252; P = .017). The PPV for CRC was 8% (20/239) in the first round versus 4% (9/252) in the second round (P = .024). Ten interval cancers were diagnosed. Thus the rate of positive results from FIT does not decrease after repeated CRC screening, but the PPVs for advanced neoplasia and for CRC are significantly lower among second-round participants who tested negative in the first round

The value of pre-operative magnetic resonance spectroscopy in the assessment of steatohepatitis in patients with colorectal liver metastasis.
Urdzik J, Bjerner T, Wanders A, Weis J, Duraj F, Haglund U, Norén A., J Hepatol. 2012 Mar;56(3):640-6. doi: 10.1016/j.jhep.2011.10.006. Epub 2011 Oct 23.

Comments: Proton magnetic resonance spectroscopy ((1)H MRS) is a reliable non-invasive tool for steatosis assessment in comparison with digital quantification of steatosis (DQS) and "classical" histopathology as shown in liver resection specimens of 35 patients with colorectal liver metastasis.

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps.
Wu CW, Ng SS, Dong YJ, Ng SC, Leung WW, Lee CW, Wong YN, Chan FK, Yu J, Sung JJ., Gut. 2012 May;61(5):739-45. doi: 10.1136/gut.2011.239236. Epub 2011 Sep 19.

Comments: Evaluation of miR-21 and miR-92a in stools of 88 patients with CRC, 57 with colorectal polyps and 101 healthy controls. Stool-based miRNA detected by real-time quantitative reverse transcription PCR were stable with highly reproducible detection. miR-21 and miR-92a was significantly higher in CRC tissues compared with normal tissues (p<0.0001). CRC had a significantly higher stool miR-21 (p<0.01) and miR-92a level (p<0.0001) compared with controls. Stool miR-92a, but not miR-21, was higher in polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. Removal of tumour resulted in reduced stool miR-21 and miR-92a levels .

Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial.
Benamouzig R, Uzzan B, Deyra J, Martin A, Girard B, Little J, Chaussade S;Association pour la Prévention par l'Aspirine du Cancer Colorectal Study Group(APACC)., Gut. 2012 Feb;61(2):255-61. doi: 10.1136/gutjnl-2011-300113. Epub 2011 Sep 2.

Comments: Daily low-dose aspirin decreased adenoma recurrence significantly at 1 year but not at year 4. This discrepancy might be explained by a differential effect of aspirin according to the natural history of the polyp.

Clinical practice. Screening for colorectal cancer.
Lieberman DA, N Engl J Med. 2009 Sep 17;361(12):1179-87

American College of Gastroenterology guidelines for colorectal cancer screening 2008.
Rex DK, Johnson DA, Anderson JC, Schoenfeld PS, Burke CA, Inadomi JM, American College of Gastroenterology, Am J Gastroenterol. 2009 Mar;104(3):739-50 Cat: Journal Article, Practice Guideline

Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer.
Rex DK, Kahi CJ, Levin B, Smith RA, Bond JH, Brooks D, Burt RW, Byers T, Fletcher RH, Hyman N, Johnson D, Kirk L, Lieberman DA, Levin TR, O'Brien MJ, Simmang C, Thorson AG, Winawer SJ, American Cancer Society, US Multi-Society Task Force on Colorectal Cancer, Gastroenterology. 2006 May;130(6):1865-71 - PubTypeList: Journal Article, Practice Guideline, Review

Transanal endoscopic microsurgery: where are we now?
Maslekar S, Beral DL, White TJ, Pillinger SH, Monson JR, Dig Surg. 2006;23(1-2):12-22 - PubTypeList: Journal Article, Review

ASGE guideline: colorectal cancer screening and surveillance.
Davila RE, Rajan E, Baron TH, Adler DG, Egan JV, Faigel DO, Gan SI, Hirota WK, Leighton JA, Lichtenstein D, Qureshi WA, Shen B, Zuckerman MJ, VanGuilder T, Fanelli RD, Standards of Practice Committee, American Society for Gastrointestinal Endoscopy, Gastrointest Endosc. 2006 Apr;63(4):546-57 - PubTypeList: Journal Article, Practice Guideline

Increasing incidence of colorectal cancer in Asia: implications for screening.
Sung JJ, Lau JY, Goh KL, Leung WK, Asia Pacific Working Group on Colorectal Cancer, Lancet Oncol. 2005 Nov;6(11):871-6 - PubTypeList: Journal Article, Review

 

Time to benefit for colorectal cancer screening: survival meta-analysis of flexible sigmoidoscopy trials.
Tang V, Boscardin WJ, Stijacic-Cenzer I, Lee SJ., BMJ. 2015 Apr 16;350:h1662. doi: 10.1136/bmj.h1662. Erratum in: BMJ. 2015;350:h2228.
 

 

Anaesthetic techniques for risk of malignant tumour recurrence.
Cakmakkaya OS, Kolodzie K, Apfel CC, Pace NL., Cochrane Database Syst Rev. 2014 Nov 7;11:CD008877. doi: 10.1002/14651858.CD008877.pub2. Review.
Comments: Influence of anaesthesia on results of surgery

 

Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US Multi-Society Task Force on Colorectal Cancer.
Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Richard Boland C, Giardello FM, Lieberman DA, Levin TR, Rex DK; US Multi-Society Task Force on Colorectal Cancer., Am J Gastroenterol. 2014 Oct;109(10):1528-45. doi: 10.1038/ajg.2014.272. Epub 2014 Sep 16. No abstract available.
Comments: About colon cleansing

 

Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer.
Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland CR, Giardello FM, Lieberman DA, Levin TR, Rex DK; US Multi-Society Task Force on Colorectal Cancer., Gastroenterology. 2014 Oct;147(4):903-24. doi: 10.1053/j.gastro.2014.07.002. Review. No abstract available.
Comments: About colon cleansing

 

What level of bowel prep quality requires early repeat colonoscopy: systematic review and meta-analysis of the impact of preparation quality on adenoma detection rate.
Clark BT, Rustagi T, Laine L., Am J Gastroenterol. 2014 Nov;109(11):1714-23; quiz 1724. doi: 10.1038/ajg.2014.232. Epub 2014 Aug 19. Review.
Comments: Bowel cleansing and adenoma detection rate

 

Cold snare polypectomy vs. Cold forceps polypectomy using double-biopsy technique for removal of diminutive colorectal polyps: a prospective randomized study.
Lee CK(1), Shim JJ, Jang JY., Am J Gastroenterol. 2013 Oct;108(10):1593-600. doi: 10.1038/ajg.2013.302. Epub2013 Sep 17.

Comments: Cold snare polypectomy (CSP) is superior to cold forceps for the endoscopic removal of diminutive colorectal polyps (DCPs; ≤5 mm).

 

Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J., Cochrane Database Syst Rev. 2013 Jun 5;6:CD009058. doi:10.1002/14651858.CD009058.pub2.

Comments: Only one randomised clinical trial; thus insufficient evidence to conclude that cryotherapy brings any significant benefit in pts with liver metastases

 

Electro-coagulation for liver metastases.
Riemsma RP, Bala MM, Wolff R, Kleijnen J., Cochrane Database Syst Rev. 2013 May 31;5:CD009497. doi:10.1002/14651858.CD009497.pub2.

Comments: Insufficient evidence to conclude that elecrto-coagulation is helpful in patients with colonic cancer liver metastases

 

Percutaneous ethanol injection for liver metastases.
Riemsma RP, Bala MM, Wolff R, Kleijnen J., Cochrane Database Syst Rev. 2013 May 31;5:CD008717. doi:10.1002/14651858.CD008717.pub2.

Comments: Only one small randomised trial: insufficient to conclude that addition of PEI to TACE, as compared with TACE alone, is helpful in patients with liver metastases

 

Uptake of genetic testing by relatives of lynch syndrome probands: a systematic review.
Sharaf RN, Myer P, Stave CD, Diamond LC, Ladabaum U., Clin Gastroenterol Hepatol. 2013 Sep;11(9):1093-100. doi:10.1016/j.cgh.2013.04.044. Epub 2013 May 10.

Comments: Genetic testing appears to be underutilized by first-degree relatives of patients with Lynch syndrome

 

Transarterial (chemo)embolisation versus no intervention or placebo intervention for liver metastases.
Riemsma RP, Bala MM, Wolff R, Kleijnen J., Cochrane Database Syst Rev. 2013 Apr 30;4:CD009498. doi:10.1002/14651858.CD009498.pub3.

Comments: In pts with liver metastases no significant survival benefit was found in the embolisation group in comparison with the palliation group.

 

Association between constipation and colorectal cancer: systematic review and meta-analysis of observational studies.
Power AM, Talley NJ, Ford AC., Am J Gastroenterol. 2013 Jun;108(6):894-903; quiz 904. doi: 10.1038/ajg.2013.52. Epub 2013 Mar 12.

Comments: No increase in prevalence of CRC in patients or individuals with constipation.

 

Pathology of rodent models of intestinal cancer: progress report and recommendations.
Washington MK, Powell AE, Sullivan R, Sundberg JP, Wright N, Coffey RJ, Dove WF., Gastroenterology. 2013 Apr;144(4):705-17. doi: 10.1053/j.gastro.2013.01.067. Epub 2013 Feb 12.

Comments: Recent developments in rodent modeling of intestinal neoplasia,the role of stem cells and the creation of models of metastatic intestinal cancer.

 

Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentrerandomised trial.
Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R, Yao G,Kay C, Burling D, Faiz O, Teare J, Lilford RJ, Morton D, Wardle J, Halligan S;SIGGAR investigators., Lancet. 2013 Apr 6;381(9873):1194-202. doi: 10.1016/S0140-6736(12)62186-2. Epub 2013 Feb 14.

Comments: Colonoscopy (n=1072) or CompTomographyC (n=538).: CTC missed 1 of 29 colorectal cancers and colonoscopy missed none (of 55). Detection rate: 11% for both procedures

 

Nurse observation during colonoscopy increases polyp detection: a randomized prospective study.
Aslanian HR, Shieh FK, Chan FW, Ciarleglio MM, Deng Y, Rogart JN, Jamidar PA,Siddiqui UD., Am J Gastroenterol. 2013 Feb;108(2):166-72. doi: 10.1038/ajg.2012.237.

 

Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data.
Vinogradova Y, Coupland C, Hippisley-Cox J., BMJ. 2013 Jan 16;346:f114. doi: 10.1136/bmj.f114.

 

Narrow band imaging to differentiate neoplastic and non-neoplastic colorectal polyps in real time: a meta-analysis of diagnostic operating characteristics.
McGill SK, Evangelou E, Ioannidis JP, Soetikno RM, Kaltenbach T., Gut. 2013 Apr 17. [Epub ahead of print]

Comments: Narrow band imaging diagnosis of colorectal polyps is highly accurate; the area under the HSROC curve exceeds 0.90.

 

Comparative effectiveness and cost-effectiveness of screening colonoscopy vs. sigmoidoscopy and alternative strategies.
Sharaf RN, Ladabaum U., Am J Gastroenterol. 2013 Jan;108(1):120-32. doi: 10.1038/ajg.2012.380. Epub 2012 Dec 18.

 

Transparent cap colonoscopy versus standard colonoscopy to improve caecalintubation.
Morgan J, Thomas K, Lee-Robichaud H, Nelson RL, Braungart S., Cochrane Database Syst Rev. 2012 Dec 12;12:CD008211. doi:10.1002/14651858.CD008211.pub3.

 

Effect of flexible sigmoidoscopy-based screening on incidence and mortality of colorectal cancer: a systematic review and meta-analysis of randomized controlledtrials.
Elmunzer BJ, Hayward RA, Schoenfeld PS, Saini SD, Deshpande A, Waljee AK., PLoS Med. 2012;9(12):e1001352. doi: 10.1371/journal.pmed.1001352. Epub 2012 Dec 4.

 

An endoscopic quality improvement program improves detection of colorectal adenomas.
Coe SG, Crook JE, Diehl NN, Wallace MB., Am J Gastroenterol. 2013 Feb;108(2):219-26; quiz 227. doi: 10.1038/ajg.2012.417. Epub 2013 Jan 8.

 

Real-time optical biopsy of colon polyps with narrow band imaging in community practice does not yet meet key thresholds for clinical decisions.
Ladabaum U, Fioritto A, Mitani A, Desai M, Kim JP, Rex DK, Imperiale T,Gunaratnam N., Gastroenterology. 2013 Jan;144(1):81-91. doi: 10.1053/j.gastro.2012.09.054. Epub 2012 Oct 3.

 

Burden of colonoscopy compared to non-cathartic CT-colonography in a colorectal cancer screening programme: randomised controlled trial.
de Wijkerslooth TR, de Haan MC, Stoop EM, Bossuyt PM, Thomeer M, Essink-Bot ML,van Leerdam ME, Fockens P, Kuipers EJ, Stoker J, Dekker E., Gut. 2012 Nov;61(11):1552-9. Epub 2011 Dec 23.

 

Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial.
de Wijkerslooth TR, Stoop EM, Bossuyt PM, Mathus-Vliegen EM, Dees J, Tytgat KM,van Leerdam ME, Fockens P, Kuipers EJ, Dekker E., Gut. 2012 Oct;61(10):1426-34. doi: 10.1136/gutjnl-2011-301

 

Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests.
Logan RF, Patnick J, Nickerson C, Coleman L, Rutter MD, von Wagner C; English Bowel Cancer Screening Evaluation Committee., Gut. 2012 Oct;61(10):1439-46. Epub 2011 Dec 7.

 

Dietary flavonoid for preventing colorectal neoplasms.
Jin H, Leng Q, Li C., Cochrane Database Syst Rev. 2012 Aug 15;8:CD009350. doi:10.1002/14651858.CD009350.pub2.

Comments: Cochrane review documenting insufficient evidence regarding flavonoid intake for prevention of colorectal neoplasms maybe partly due to the difficulty to determine flavonoid intake. A significant reduced risk of CRC was found with high intake of epicatechin

 

Long term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A., Cochrane Database Syst Rev. 2012 Jul 11;7:CD004143. doi:10.1002/14651858.CD004143.pub4.

Comments: Long term hormone therapy in postmenopausal women is not indicated for prevention of cardiovascular disease or dementia, nor for deterioration of cognitive function. HT is considered effective for the prevention of osteoporosis, but it can only be recommended when non-oestrogen therapies are unsuitable.

 

Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis.
Okabayashi K, Ashrafian H, Hasegawa H, Yoo JH, Patel VM, Harling L, Rowland SP,Ali M, Kitagawa Y, Darzi A, Athanasiou T., Am J Gastroenterol. 2012 Aug;107(8):1175-85; quiz 1186. doi:10.1038/ajg.2012.180. Epub 2012 Jun 26.

Comments: A BMI of =25 predisposes to a higher prevalence of colorectal adenomas (OR=1.24) in a dose-response relationship.

 

The NordICC Study: rationale and design of a randomized trial on colonoscopy screening for colorectal cancer.
Kaminski MF, Bretthauer M, Zauber AG, Kuipers EJ, Adami HO, van Ballegooijen M, Regula J, van Leerdam M, Stefansson T, Påhlman L, Dekker E, Hernán MA, Garborg K, Hoff G., Endoscopy. 2012 Jul;44(7):695-702. doi: 10.1055/s-0032-1306895. Epub 2012 Jun 21.

Comments: This paper describes the rationale and design of the NordICC trial as a multinational, randomized controlled trial aiming at investigating the effect of colonoscopy screening on colorectal cancer (CRC) incidence and mortality.

 

Radiofrequency ablation in the treatment of liver metastases from colorectal cancer.
Cirocchi R, Trastulli S, Boselli C, Montedori A, Cavaliere D, Parisi A, Noya G, Abraha I., Cochrane Database Syst Rev. 2012 Jun 13;6:CD006317. doi:10.1002/14651858.CD006317.pub3.

Comments: This systematic review was not able to provide significant information on overall survival to recommend RFA for a radical oncological treatment of liver metastases from colorectal cancer.

 

Knee length versus thigh length graduated compression stockings for prevention of deep vein thrombosis in postoperative surgical patients.
Sajid MS, Desai M, Morris RW, Hamilton G., Cochrane Database Syst Rev. 2012 May 16;5:CD007162. doi:10.1002/14651858.CD007162.pub2.

Comments: Review to determine whether or not Knee or Tight length compression stockings are better to reduce the incidence of deep vein thrombosis (DVT) in hospitalized patients. At present not enough good data are available.

 

Hyperbaric oxygen therapy for late radiation tissue injury.
Bennett MH, Feldmeier J, Hampson N, Smee R, Milross C., Cochrane Database Syst Rev. 2012 May 16;5:CD005005. doi:10.1002/14651858.CD005005.pub3.

Comments: Hyperbaric oxygen therapy appears to reduce late radiation tissue injury occurring as osteoradionecrosis, radiation proctitis, surgical flaps after hemimandibulectomy and irradiated tooth sockets

 

Herbal medicines for advanced colorectal cancer.
Guo Z, Jia X, Liu JP, Liao J, Yang Y., Cochrane Database Syst Rev. 2012 May 16;5:CD004653. doi:10.1002/14651858.CD004653.pub2.

Comments: 20 trials compared the use of herbal medicines with chemotherapy and chemotherapy alone in advanced stage colorectal cancers: Quxie capsule decreased mortality rate (RR 0.17) wheras other herbs.also seemed beneficial.

 

Risk for colorectal cancer in persons with a family history of adenomatous polyps: a systematic review.
Imperiale TF, Ransohoff DF., Ann Intern Med. 2012 May 15;156(10):703-9. doi:10.1059/0003-4819-156-10-201205150-00006.

Comments: Properly designed studies are needed to measure the risk for colorectal cancer in persons who have first-degree relatives with adenomatous polyps (adenomas).

 

Hyperbaric oxygenation for tumour sensitisation to radiotherapy.
Bennett MH, Feldmeier J, Smee R, Milross C., Cochrane Database Syst Rev. 2012 Apr 18;4:CD005007. doi:10.1002/14651858.CD005007.pub3.

Comments: Hyperbaric oxygenation therapy with radiotherapy improves local tumour control and mortality for cancers of the head and neck, and local tumour recurrence, but can be associated with significant adverse effects including oxygen toxic seizures and severe tissue radiation injury.

 

Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies.
Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C,Somsouk M, El-Nachef N, Hayward RA., Arch Intern Med. 2012 Apr 9;172(7):575-82. doi: 10.1001/archinternmed.2012.332.

Comments: The adherance to a previously agreed screening protocol for Colorectal CA is disappointing: only 38% completed recommended colonoscopy, 67% FOBT (67%) and 69% the choice between FOBT or colonoscopy (69%) (P < .001). Latinos and Asians (primarily Chinese) completed screening more often than African Americans. Moreover, nonwhite participants adhered more often to FOBT, while whites adhered more often to colonoscopy.

 

Factors influencing the miss rate of polyps in a back-to-back colonoscopy study.
Leufkens AM, van Oijen MG, Vleggaar FP, Siersema PD., Endoscopy. 2012 May;44(5):470-5. doi: 10.1055/s-0031-1291666. Epub 2012 Mar 22.

Comments: A quarter of polyps were missed during colonoscopy, especially when > 2 polyps were present and more so in the left colon then in the right colon.

 

Workload and surgeon's specialty for outcome after colorectal cancer surgery.
Archampong D, Borowski D, Wille-Jørgensen P, Iversen LH., Cochrane Database Syst Rev. 2012 Mar 14;3:CD005391. doi:10.1002/14651858.CD005391.pub3.

Comments: Overall five year survival was significantly higher for colorectal cancer treated in high-volume hospitals (HR=0.90) or by high-volume surgeons (HR=0.88) and colorectal specialists (HR=0.81)

 

Cost effectiveness of strategies to combat breast, cervical, and colorectal cancer in sub-Saharan Africa and South East Asia: mathematical modelling study.
Ginsberg GM, Lauer JA, Zelle S, Baeten S, Baltussen R., BMJ. 2012 Mar 2;344:e614. doi: 10.1136/bmj.e614.

Comments: Study showing that proecedures are highly cost effective in African and Asian sub-regions: in cervical cancer control:smear tests or visual inspection; in colorectal cancer: screening through colonoscopy; in breast cancer control, mammography screening.

 

Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Spada C, Hassan C, Galmiche JP, Neuhaus H, Dumonceau JM, Adler S, Epstein O, Gay G, Pennazio M, Rex DK, Benamouzig R, de Franchis R, Delvaux M, Devière J, EliakimR, Fraser C, Hagenmuller F, Herrerias JM, Keuchel M, Macrae F, Munoz-Navas M,Ponchon T, Quintero E, Riccioni ME, Rondonotti E, Marmo R, Sung JJ, Tajiri H,Toth E, Triantafyllou K, Van Gossum A, Costamagna G; European Society of Gastrointestinal Endoscopy., Endoscopy. 2012 May;44(5):527-36. doi: 10.1055/s-0031-1291717. Epub 2012 Mar 2.

Comments: Colon capsule endoscopy is feasible and safe and appears to be accurate in average-risk individuals, but is still missing some cancer detectable by colonoscopy. Improvements are needed.

 

Antibiotic prophylaxis for hernia repair.
Sanchez-Manuel FJ, Lozano-Garcìa J, Seco-Gil JL., Cochrane Database Syst Rev. 2012 Feb 15;2:CD003769. doi:10.1002/14651858.CD003769.pub4.

Comments: This Cochrane Systematic review concludes that the administration of antibiotic prophylaxis for elective inguinal hernia repair is not to be universally recommended

 

Narrow band imaging versus conventional white light colonoscopy for the detection of colorectal polyps.
Nagorni A, Bjelakovic G, Petrovic B., Cochrane Database Syst Rev. 2012 Jan 18;1:CD008361. doi:10.1002/14651858.CD008361.pub2.

Comments: Narrow band imaging colonoscopy does not seem better than white light colonoscopy for detection of colorectal polyps (11 randomised trials)

 

Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: a meta-analysis.
Pasha SF, Leighton JA, Das A, Harrison ME, Gurudu SR, Ramirez FC, Fleischer DE, Sharma VK., Am J Gastroenterol. 2012 Mar;107(3):363-70; quiz 371. doi: 10.1038/ajg.2011.436. Epub 2011 Dec 20.

Comments: High-definition colonoscopes have the advantage of increased field of visualization and higher resolution; narrow band imaging utilizes narrow band filters for enhanced visualization of surface architecture and capillary pattern. Compared with high-definition white light endoscopy, HD-narrow band imaging does not increase the yield of colon polyps, adenomas, or flat adenomas.

 

Double-balloon endoscopy versus magnet-imaging enhanced colonoscopy for difficult colonoscopies, a randomized study.
Suzuki T, Matsushima M, Tsukune Y, Fujisawa M, Yazaki T, Uchida T, Gocyo S, OkitaI, Shirakura K, Sasao K, Saito T, Sakamoto I, Igarashi M, Koike J, Takagi A, MineT., Endoscopy. 2012 Jan;44(1):38-42. doi: 10.1055/s-0030-1256875. Epub 2011 Dec 5.

Comments: A total of 94 patients with incomplete or technically difficult colonoscopy were randomly assigned to receive either double-balloon endoscopy or magnetic endoscope imaging to improve success rates for colonoscopy: DBE was more useful.

 

Safety of cold polypectomy for <10mm polyps at colonoscopy: a prospective multicenter study.
Repici A, Hassan C, Vitetta E, Ferrara E, Manes G, Gullotti G, Princiotta A, Dulbecco P, Gaffuri N, Bettoni E, Pagano N, Rando G, Strangio G, Carlino A, RomeoF, de Paula Pessoa Ferreira D, Zullo A, Ridola L, Malesci A., Endoscopy. 2012 Jan;44(1):27-31. doi: 10.1055/s-0031-1291387. Epub 2011 Nov 28.

Comments: Cold polypectomy (without electrocautery) by means of biopsy forceps or snare for removal of subcentimetric polyps was shown to be safe wit a low rate of postpolypectomy bleeding (1.8%) and due to the high efficacy of endoscopic hemostasis, as documented by this prospective multicenter trial of 1015 <10-mm polyps (15.5% on antiplatelet agents). Advanced neoplasia prevalence in polyps ≤5mm was as high as 8.7%.

 

Chinese guidelines for the diagnosis and comprehensive treatment of hepaticmetastasis of colorectal cancer.
Xu J, Qin X, Wang J, Zhang S, Zhong Y, Ren L, Wei Y, Zeng S, Wan D, Zheng S;Society of Surgery; Chinese Medical Association; Committee of Colorectal Cancer, Chinese Anti-cancer Association., J Cancer Res Clin Oncol. 2011 Sep;137(9):1379-96. Epub 2011 Jul 28.

 

Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer.
Rahbari NN, Aigner M, Thorlund K, Mollberg N, Motschall E, Jensen K, Diener MK,Büchler MW, Koch M, Weitz J., Gastroenterology. 2010 May;138(5):1714-26. Epub 2010 Jan 25.

 

Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum.
Washington MK, Berlin J, Branton P, Burgart LJ, Carter DK, Fitzgibbons PL, Halling K, Frankel W, Jessup J, Kakar S, Minsky B, Nakhleh R, Compton CC, Members of the Cancer Committee, College of American Pathologists, Arch Pathol Lab Med. 2009 Oct;133(10):1539-51

 

What is the value of computered tomography colonography in patients screening positive for fecal occult blood? A systematic review and economic evaluation.
Walleser S, Griffiths A, Lord SJ, Howard K, Solomon MJ, Gebski V, Clin Gastroenterol Hepatol. 2007 Dec;5(12):1439-46; quiz 1368 - PubTypeList: Journal Article, Review

 

New stool screening tests for colorectal cancer.
Young GP, Cole S, Digestion. 2007;76(1):26-33 - PubTypeList: Journal Article, Review

 

Screening for colorectal cancer in average-risk populations.
Lieberman D, Am J Med. 2006 Sep;119(9):728-35 - PubTypeList: Journal Article, Review

 

Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review.
Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H, Clin Infect Dis. 2006 Jul 15;43(2):223-33 - PubTypeList: Journal Article, Review

 

The postoperative surveillance of patients with colon cancer and rectal cancer.
Abir F, Alva S, Longo WE, Audiso R, Virgo KS, Johnson FE, Am J Surg. 2006 Jul;192(1):100-8 - PubTypeList: Journal Article, Review

 

[Screening and prevention of carcinoma of the colon and rectum]
Weber C, Ther Umsch. 2006 May;63(5):333-7 - PubTypeList: Journal Article, Review

 

Review in depth and meta-analysis of controlled trials on colorectal cancer screening by faecal occult blood test.
Heresbach D, Manfredi S, D'halluin PN, Bretagne JF, Branger B, Eur J Gastroenterol Hepatol. 2006 Apr;18(4):427-33 - PubTypeList: Journal Article, Meta-Analysis, Review

 

CT colonography for colon cancer screening.
Banerjee S, Van Dam J, Gastrointest Endosc. 2006 Jan;63(1):121-33 - PubTypeList: Journal Article, Review

 

Surveillance colonoscopy in individuals at risk for hereditary nonpolyposis colorectal cancer: an evidence-based review.
Johnson PM, Gallinger S, McLeod RS, Dis Colon Rectum. 2006 Jan;49(1):80-93; discussion 94-5 - PubTypeList: Journal Article, Meta-Analysis

 

AGA Future Trends Committee report: Colorectal cancer: a qualitative review of emerging screening and diagnostic technologies.
Regueiro CR, AGA Future Trends Committee, Gastroenterology. 2005 Sep;129(3):1083-103 - PubTypeList: Journal Article, Review

 

Mass screening with CT colonography: should the radiation exposure be of concern?
Brenner DJ, Georgsson MA, Gastroenterology. 2005 Jul;129(1):328-37 - PubTypeList: Journal Article, Review

 

Genetic testing for inherited colon cancer.
Burt R, Neklason DW, Gastroenterology. 2005 May;128(6):1696-716 - PubTypeList: Journal Article, Review

 

Colon cancer screening in 2005: status and challenges.
Ransohoff DF, Gastroenterology. 2005 May;128(6):1685-95 - PubTypeList: Journal Article, Review

 

Colorectal cancer at a young age.
Terdiman JP, Gastroenterology. 2005 Apr;128(4):1067-76 - PubTypeList: Journal Article, Review

 

Critical issues in the identification and management of patients with hereditary non-polyposis colorectal cancer.
Lackner C, Hoefler G, Eur J Gastroenterol Hepatol. 2005 Mar;17(3):317-22 - PubTypeList: Journal Article, Review

 

Fibrin glue instillation under skin flaps to prevent seroma-related morbidity following breast and axillary surgery.
Sajid MS, Hutson KH, Rapisarda IF, Bonomi R., Cochrane Database Syst Rev. 2013 May 31;5:CD009557. doi:10.1002/14651858.CD009557.pub2.

 

Personalised risk communication for informed decision making about taking screening tests.
Edwards AG, Naik G, Ahmed H, Elwyn GJ, Pickles T, Hood K, Playle R., Cochrane Database Syst Rev. 2013 Feb 28;2:CD001865. doi:10.1002/14651858.CD001865.pub3.

 

Screening for prostate cancer.
Ilic D, Neuberger MM, Djulbegovic M, Dahm P., Cochrane Database Syst Rev. 2013 Jan 31;1:CD004720. doi:10.1002/14651858.CD004720.pub3.

 

Reasons for participation and nonparticipation in colorectal cancer screening: a randomized trial of colonoscopy and CT colonography.
de Wijkerslooth TR, de Haan MC, Stoop EM, Bossuyt PM, Thomeer M, van Leerdam ME, Essink-Bot ML, Fockens P, Kuipers EJ, Stoker J, Dekker E., Am J Gastroenterol. 2012 Dec;107(12):1777-83. doi: 10.1038/ajg.2012.140.

 

Screening for rectal cancer: will it improve cure rates?
Tweedle EM, Rooney PS, Watson AJ, Clin Oncol (R Coll Radiol). 2007 Nov;19(9):639-48 - PubTypeList: Journal Article, Review

 

Colorectal cancer screening in primary care.
Lieberman D, Gastroenterology. 2007 Jun;132(7):2591-4 - PubTypeList: Comment, Editorial, Review

 

Colorectal cancer screening by colonoscopy--current issues.
Kaminski MF, Regula J, Digestion. 2007;76(1):20-5 - PubTypeList: Journal Article, Review

 

Genetic alterations in sporadic and hereditary colorectal cancer: implementations for screening and follow-up.
Souglakos J, Dig Dis. 2007;25(1):9-19 - PubTypeList: Journal Article, Review

 

Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review.
Saini SD, Kim HM, Schoenfeld P, Gastrointest Endosc. 2006 Oct;64(4):614-26 - PubTypeList: Journal Article, Meta-Analysis, Review

 

Current approaches in familial colorectal cancer: a clinical perspective.
Lynch PM, J Natl Compr Canc Netw. 2006 Apr;4(4):421-30 - PubTypeList: Journal Article, Review

 

Does fecal occult blood testing really reduce mortality? A reanalysis of systematic review data.
Moayyedi P, Achkar E, Am J Gastroenterol. 2006 Feb;101(2):380-4 - PubTypeList: Journal Article, Review

 

Cutting cost and increasing access to colorectal cancer screening: another approach to following the guidelines.
Fisher JA, Fikry C, Troxel AB, Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):108-13 - PubTypeList: Journal Article, Review

 

Virtual colonoscopy for colorectal cancer screening: current status.
Heiken JP, Peterson CM, Menias CO, Cancer Imaging. 2005 Nov 23;5 Spec No A:S133-9 - PubTypeList: Journal Article, Review

 

Update on postoperative colorectal cancer surveillance.
Schwartz RW, McKenzie S, Curr Surg. 2005 Sep-Oct;62(5):491-4 - PubTypeList: Journal Article, Review

 

Hereditary nonpolyposis colorectal cancer identification and surveillance of high-risk families.
Silva RV, Garicochea B, Cotti G, Maranho IC, Cutait R, Clinics. 2005 Jun;60(3):251-6 - PubTypeList: Journal Article, Review