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Constipation

Level: Clinical Trials: 49 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

  

Prucalopride is no more effective than placebo for children with functional constipation.
Mugie SM, Korczowski B, Bodi P, Green A, Kerstens R, Ausma J, Ruth M, Levine A, Benninga MA., Gastroenterology. 2014 Dec;147(6):1285-95.e1. doi: 10.1053/j.gastro.2014.09.005. Epub 2014 Sep 16.
Comments: Negative results of prucalopride in children

 

Comparative study between surgical and non-surgical treatment of anismus inpatients with symptoms of obstructed defecation: a prospective randomized study.
Faried M, El Nakeeb A, Youssef M, Omar W, El Monem HA., J Gastrointest Surg. 2010 Aug;14(8):1235-43. Epub 2010 May 25.

 

A randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.
Jamal MM, Adams AB, Jansen JP, Webster LR., Am J Gastroenterol. 2015 May;110(5):725-32. doi: 10.1038/ajg.2015.106. Epub 2015 Apr 28.
 

 

Treatment efficacy of sacral nerve stimulation in slow transit constipation: a two-phase, double-blind randomized controlled crossover study.
Dinning PG, Hunt L, Patton V, Zhang T, Szczesniak M, Gebski V, Jones M, Stewart P, Lubowski DZ, Cook IJ., Am J Gastroenterol. 2015 May;110(5):733-40. doi: 10.1038/ajg.2015.101. Epub 2015 Apr 21.
 

 

A randomized, double-blind, placebo-controlled, phase 3 trial to evaluate the efficacy, safety, and tolerability of prucalopride in men with chronic constipation.
Yiannakou Y, Piessevaux H, Bouchoucha M, Schiefke I, Filip R, Gabalec L, Dina I, Stephenson D, Kerstens R, Etherson K, Levine A., Am J Gastroenterol. 2015 May;110(5):741-8. doi: 10.1038/ajg.2015.115. Epub 2015 Apr 14.
 

 

Rifaximin therapy for patients with irritable bowel syndrome withoutconstipation.
Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, BorteyE, Forbes WP; TARGET Study Group., N Engl J Med. 2011 Jan 6;364(1):22-32.

 

Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation.
Attaluri A, Donahoe R, Valestin J, Brown K, Rao SS., Aliment Pharmacol Ther. 2011 Apr;33(7):822-8. doi:10.1111/j.1365-2036.2011.04594.x. Epub 2011 Feb 15.

 

A double-blind, placebo-controlled study of prucalopride in elderly patients withchronic constipation.
Müller-Lissner S, Rykx A, Kerstens R, Vandeplassche L., Neurogastroenterol Motil. 2010 Sep;22(9):991-8, e255. Epub 2010 Jun 7.

 

Chenodeoxycholate in females with irritable bowel syndrome-constipation: apharmacodynamic and pharmacogenetic analysis.
Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.

 

A dose determination study of polyethylene glycol 4000 in constipated children: factors influencing the maintenance dose.
C Dupont, B Leluyer, F Amar, N Kalach, PH Benhamou, O Mouterde, PY Vannerom, J Pediatr Gastroenterol Nutr. 2006 Feb:178-85

 

A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation.
J Tack, S Muller-Lissner, P Bytzer, R Corinaldesi, L Chang, A Viegas, S Schnekenbuehl, C Dunger-Baldauf, P Rueegg, Gut. 2005 Dec:1707-13

 

A randomized, controlled trial of transanal irrigation versus conservative bowel management in spinal cord-injured patients.
P Christensen, G Bazzocchi, M Coggrave, R Abel, C Hultling, K Krogh, S Media, S Laurberg, Gastroenterology. 2006 Sep:738-47

 

A randomized, multicenter comparison of polyethylene glycol laxative and tegaserod in treatment of patients with chronic constipation.
JA Di Palma, MV Cleveland, J McGowan, JL Herrera, Am J Gastroenterol. 2007 Sep:1964-71

 

A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation.
JA Dipalma, MV Cleveland, J McGowan, JL Herrera, Am J Gastroenterol. 2007 Jul:1436-41

 

Biofeedback benefits only patients with outlet dysfunction, not patients with isolated slow transit constipation.
G Chiarioni, L Salandini, WE Whitehead, Gastroenterology. 2005 Jul:86-97

 

Celiac disease in an adult Turkish population with type 1 diabetes mellitus.
C Aygun, S Uraz, T Damci, Z Osar, V Yumuk, E Akdenizli, H Ilkova, Dig Dis Sci. 2005 Aug:1462-6

 

Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety.
JF Johanson, R Ueno, Aliment Pharmacol Ther. 2007 Jun 1:1351-61

 

Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation.
JF Johanson, D Morton, J Geenen, R Ueno, Am J Gastroenterol. 2008 Jan:170-7

 

Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study.
M Pimentel, S Chatterjee, EJ Chow, S Park, Y Kong, Dig Dis Sci. 2006 Aug:1297-301

 

Polyethylene glycol 4000 vs. lactulose for the treatment of neurogenic constipation in myelomeningocele children: a randomized-controlled clinical trial.
C Rendeli, E Ausili, F Tabacco, B Focarelli, A Pantanella, C Di Rocco, O Genovese, C Fundarò, Aliment Pharmacol Ther. 2006 Apr 15:1259-65

 

Review article: tegaserod for chronic constipation.
JF Johanson, Aliment Pharmacol Ther. 2004 Nov:20-4

 

Two randomized trials of linaclotide for chronic constipation.
Lembo AJ, Schneier HA, Shiff SJ, Kurtz CB, MacDougall JE, Jia XD, Shao JZ, LavinsBJ, Currie MG, Fitch DA, Jeglinski BI, Eng P, Fox SM, Johnston JM., N Engl J Med. 2011 Aug 11;365(6):527-36.

 

Chenodeoxycholate in females with irritable bowel syndrome-constipation: apharmacodynamic and pharmacogenetic analysis.
Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.

 

Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4agonist with high intrinsic activity, in chronic idiopathic constipation - a4-week, randomized, double-blind, placebo-controlled, dose-response study.
Goldberg M, Li YP, Johanson JF, Mangel AW, Kitt M, Beattie DT, Kersey K, Daniels O., Aliment Pharmacol Ther. 2010 Nov;32(9):1102-12. doi:10.1111/j.1365-2036.2010.04456.x. Epub 2010 Sep 22.

 

A randomized, double-blind, placebo-controlled trial of polyethylene glycoleffects on fasting and postprandial rectal sensitivity and symptoms inhypersensitive constipation-predominant irritable bowel syndrome.
Awad RA, Camacho S., Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x.

  

Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation.
Manini ML, Camilleri M, Goldberg M, Sweetser S, McKinzie S, Burton D, Wong S, Kitt MM, Li YP, Zinsmeister AR, Neurogastroenterol Motil. 2009 Aug 18;

  

Long-term outcome and safety of transanal irrigation for constipation and fecal incontinence.
Christensen P, Krogh K, Buntzen S, Payandeh F, Laurberg S, Dis Colon Rectum. 2009 Feb;52(2):286-92 Cat: Journal Article

  

Neuroimmune interaction and anorectal motility in children with food allergy-related chronic constipation.
Borrelli O, Barbara G, Di Nardo G, Cremon C, Lucarelli S, Frediani T, Paganelli M, De Giorgio R, Stanghellini V, Cucchiara S, Am J Gastroenterol. 2009 Feb;104(2):454-63 Cat: Journal Article

 

Pilot study on the effect of linaclotide in patients with chronic constipation.
Johnston JM, Kurtz CB, Drossman DA, Lembo AJ, Jeglinski BI, MacDougall JE, Antonelli SM, Currie MG, Am J Gastroenterol. 2009 Jan;104(1):125-32 Cat: Journal Article, Multicenter Study, Randomized Controlled Trial

 

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study.
Quigley EM, Vandeplassche L, Kerstens R, Ausma J, Aliment Pharmacol Ther. 2009 Feb 1;29(3):315-28 Cat: Journal Article

 

Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies.
Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, Ueno R, Aliment Pharmacol Ther. 2009 Feb 1;29(3):329-41 Cat: Journal Article

 

Comparative study on two colonic bowel preparations for patients with chronic constipation.
Chen H, Li X, Ge Z, Scand J Gastroenterol. 2009;44(3):375-9 Cat: Journal Article

 

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives.
Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L, Gut. 2009 Mar;58(3):357-65 Cat: Journal Article

 

A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial.
Kokke FT, Scholtens PA, Alles MS, Decates TS, Fiselier TJ, Tolboom JJ, Kimpen JL, Benninga MA, J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):592-7 Cat: Journal Article, Randomized Controlled Trial

 

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.
Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, Goupil Feuillerat N, Schlumberger A, Jakob S, Whorwell PJ, Aliment Pharmacol Ther. 2008 Sep 17; Cat: Journal Article

 

Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome--multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting.
George AM, Meyers NL, Hickling RI, Aliment Pharmacol Ther. 2008 May;27(9):830-7

 

Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.
V Andresen, M Camilleri, IA Busciglio, A Grudell, D Burton, S McKinzie, A Foxx-Orenstein, CB Kurtz, V Sharma, JM Johnston, MG Currie, AR Zinsmeister, Gastroenterology. 2007 Sep:761-8

 

Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome.
V Khoshoo, C Armstead, L Landry, Aliment Pharmacol Ther. 2006 Jan 1:191-6

 

Effect of tegaserod on recto-sigmoid tonic and phasic activity in constipation-predominant irritable bowel syndrome.
M Di Stefano, E Miceli, S Mazzocchi, P Tana, A Missanelli, GR Corazza, Am J Gastroenterol. 2007 Aug:1720-6

 

Efficacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled study.
S Kienzle-Horn, JM Vix, C Schuijt, H Peil, CC Jordan, MA Kamm, Aliment Pharmacol Ther. 2006 May 15:1479-88

 

Efficacy of tegaserod for functional constipation in Chinese subjects: a randomized double-blind controlled trial in a single centre.
AO On Chan, AO On Chan, W Mo Hui, G Leung, WH Hu, SK Lam, BC Wong, Aliment Pharmacol Ther. 2007 Feb 15:463-9

 

Efficacy of tegaserod in chronic constipation in men.
M Fried, JF Johanson, KA Gwee, A Wagner, E Pecher, P Rueegg, Am J Gastroenterol. 2007 Feb:362-70

 

Review article: the safety profile of tegaserod.
P Schoenfeld, Aliment Pharmacol Ther. 2004 Nov:25-30

 

Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipation.
S Muller-Lissner, MA Kamm, A Musoglu, DL Earnest, C Dunger-Baldauf, MA Shetzline, Am J Gastroenterol. 2006 Nov:2558-69; quiz 2671

 

The degree of breath methane production in IBS correlates with the severity of constipation.
S Chatterjee, S Park, K Low, Y Kong, M Pimentel, Am J Gastroenterol. 2007 Apr:837-41

 

Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial.
Chey WD, Paré P, Viegas A, Ligozio G, Shetzline MA, Am J Gastroenterol 2008 May;103(5):1217-25