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World Gastroenterology Organisation
World Gastroenterology Organisation
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Diverticular Disease

Level: Meta-analyses, Systematic reviews, Practice guidelines: 15 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention


Routine colonoscopy after left-sided acute uncomplicated diverticulitis: asystematic review.
Daniels L(1), Unlü C(1), de Wijkerslooth TR(2), Dekker E(2), Boermeester MA(1)., Gastrointest Endosc. 2014 Mar;79(3):378-89; quiz 498-498.e5. doi:10.1016/j.gie.2013.11.013. Epub 2014 Jan 14.

Comments: This systematic review suggest that the malignancy rate as detected with colonoscopy after imaging-proven uncomplicated acute diverticulitis is low.


Sigmoid diverticulitis: a systematic review.
Morris AM, Regenbogen SE, Hardiman KM, Hendren S., JAMA. 2014 Jan 15;311(3):287-97. doi: 10.1001/jama.2013.282025.

Comments: The natural history of uncomplicated diverticulitis is often benign. Of 3165 patients hospitalized for acute diverticulitis, only 13.3% had one and 3.9% a second recurrence within 8.9 yrs. 20-35% progress to chronic pain compared with 5%-25% when treated operatively. Antibiotics and fiber were not as beneficial as previously thought, mesalamine might be useful.


Antibiotics for uncomplicated diverticulitis.
Shabanzadeh DM, Wille-Jørgensen P., Cochrane Database Syst Rev. 2012 Nov 14;11:CD009092. doi:10.1002/14651858.CD009092.pub2.


Transparent cap colonoscopy versus standard colonoscopy to improve caecalintubation.
Morgan J, Thomas K, Lee-Robichaud H, Nelson RL, Braungart S., Cochrane Database Syst Rev. 2012 Dec 12;12:CD008211. doi:10.1002/14651858.CD008211.pub3.


Laparoscopic peritoneal lavage for perforated colonic diverticulitis: asystematic review.
Toorenvliet BR, Swank H, Schoones JW, Hamming JF, Bemelman WA., Colorectal Dis. 2010 Sep;12(9):862-7. Epub 2009 Sep 26.


Colonic diverticular disease in a multiracial Asian patient population has an ethnic predilection.
S Rajendra, JJ Ho, Eur J Gastroenterol Hepatol. 2005 Aug:871-5


Colonic diverticular disease: pathophysiology and clinical picture.
A Parra-Blanco, Digestion. 2006:47-57


Diverticular disease and migration--the influence of acculturation to a Western lifestyle on diverticular disease.
F Hjern, C Johansson, A Mellgren, NN Baxter, A Hjern, Aliment Pharmacol Ther. 2006 Mar 15:797-805


Management of colonic diverticular disease.
G Frieri, MT Pimpo, C Scarpignato, Digestion. 2006:58-66


Management of diverticulitis.
SE Janes, A Meagher, FA Frizelle, BMJ. 2006 Feb 4:271-5


Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
F Guagnini, M Valenti, S Mukenge, I Matias, A Bianchetti, S Di Palo, G Ferla, V Di Marzo, T Croci, Gut. 2006 Jul:946-53


A prospective study of acute admissions in a surgical unit due to diverticular disease.
SK John, NB Teo, AL Forster, Dig Surg. 2007:186-90


Comparison of outcome of POSSUM, p-POSSUM, and cr-POSSUM scoring after elective resection of the sigmoid colon for carcinoma or complicated diverticular disease.
JL Oomen, MA Cuesta, AF Engel, Scand J Gastroenterol. 2007 Jul:841-7


Outcome after emergency surgery for acute perforated diverticulitis in 200 cases.
J Vermeulen, GP Akkersdijk, MP Gosselink, WC Hop, GH Mannaerts, E van der Harst, PP Coene, WF Weidema, JF Lange, Dig Surg. 2007:361-6


The management of complicated diverticulitis and the role of computed tomography.
AM Kaiser, JK Jiang, JP Lake, G Ault, A Artinyan, C Gonzalez-Ruiz, R Essani, RW Beart Jr, Am J Gastroenterol. 2005 Apr:910-7