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Helicobacter Pylori in Developing Countries

Level: Clinical Trials: 42 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

 

Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation.
Tanigawa T, Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Oshitani N, Tarnawski AS, Arakawa T, J Gastroenterol. 2009;44 Suppl 19:8-17

  

Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial.
Zeng M, Mao XH, Li JX, Tong WD, Wang B, Zhang YJ, Guo G, Zhao ZJ, Li L, Wu DL, Lu DS, Tan ZM, Liang HY, Wu C, Li DH, Luo P, Zeng H, Zhang WJ, Zhang JY, Guo BT, Zhu FC, Zou QM., Lancet. 2015 Oct 10;386(10002):1457-64. doi: 10.1016/S0140-6736(15)60310-5. Epub 2015 Jun 30.

  

Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city.
den Hollander WJ, Holster IL, van Gilst B, van Vuuren AJ, Jaddoe VW, Hofman A, Perez-Perez GI, Kuipers EJ, Moll HA, Blaser MJ., Gut. 2015 Aug;64(8):1200-8. doi: 10.1136/gutjnl-2014-307689. Epub 2014 Aug 28.

  

Pretreatment antimicrobial susceptibility-guided vs. clarithromycin-based triple therapy for Helicobacter pylori eradication in a region with high rates of multiple drug resistance.
Park CS, Lee SM, Park CH, Koh HR, Jun CH, Park SY, Lee WS, Joo YE, Kim HS, Choi SK, Rew JS., Am J Gastroenterol. 2014 Oct;109(10):1595-602. doi: 10.1038/ajg.2014.222. Epub 2014 Aug 5.
 

 

Helicobacter pylori eradication with a capsule containing bismuth subcitratepotassium, metronidazole, and tetracycline given with omeprazole versusclarithromycin-based triple therapy: a randomised, open-label, non-inferiority,phase 3 trial.
Malfertheiner P, Bazzoli F, Delchier JC, Celiñski K, Giguère M, Rivière M,Mégraud F; Pylera Study Group., Lancet. 2011 Mar 12;377(9769):905-13. Epub 2011 Feb 21.

 

Bismuth, lansoprazole, amoxicillin and metronidazole or clarithromycin as first-line Helicobacter pylori therapy.
Zhang W, Chen Q, Liang X, Liu W, Xiao S, Graham DY, Lu H., Gut. 2015 Nov;64(11):1715-20. doi: 10.1136/gutjnl-2015-309900. Epub 2015 Sep 2.

 

14-day triple, 5-day concomitant, and 10-day sequential therapies forHelicobacter pylori infection in seven Latin American sites: a randomised trial.
Greenberg ER, Anderson GL, Morgan DR, Torres J, Chey WD, Bravo LE, Dominguez RL, Ferreccio C, Herrero R, Lazcano-Ponce EC, Meza-Montenegro MM, Peña R, Peña EM,Salazar-Martínez E, Correa P, Martínez ME, Valdivieso M, Goodman GE, Crowley JJ, Baker LH., Lancet. 2011 Aug 6;378(9790):507-14. Epub 2011 Jul 21.

 

Empirical levofloxacin-containing versus clarithromycin-containing sequentialtherapy for Helicobacter pylori eradication: a randomised trial.
Romano M, Cuomo A, Gravina AG, Miranda A, Iovene MR, Tiso A, Sica M, Rocco A,Salerno R, Marmo R, Federico A, Nardone G., Gut. 2010 Nov;59(11):1465-70.

 

Interaction of Helicobacter pylori infection and nonsteroidal anti-inflammatorydrugs in gastric and duodenal ulcers.
Venerito M, Malfertheiner P., Helicobacter. 2010 Aug;15(4):239-50.

 

Systematic review: Helicobacter pylori and the risk of upper gastrointestinalbleeding risk in patients taking aspirin.
Fletcher EH, Johnston DE, Fisher CR, Koerner RJ, Newton JL, Gray CS., Aliment Pharmacol Ther. 2010 Oct;32(7):831-9. doi:10.1111/j.1365-2036.2010.04415.x.

 

Empirical levofloxacin-containing versus clarithromycin-containing sequentialtherapy for Helicobacter pylori eradication: a randomised trial.
Romano M, Cuomo A, Gravina AG, Miranda A, Iovene MR, Tiso A, Sica M, Rocco A,Salerno R, Marmo R, Federico A, Nardone G., Gut. 2010 Nov;59(11):1465-70.

 

Efficacy of three different dosages of esomeprazole in the long-term managementof reflux disease: a prospective, randomized study, using the wireless Bravo pHsystem.
Vasiliadis KV, Viazis N, Vlachogiannakos J, Sgouros SN, Stefanidis G, Archimandritis A, Karamanolis DG., Am J Gastroenterol. 2010 Feb;105(2):308-13. Epub 2009 Oct 6.

 

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteers.
Nichita C, Abdou AE, Maerten P, Herranz M, Mouret N, Thalmann C, Michetti PF, Dorta G, Aliment Pharmacol Ther. 2009 Nov 15;30(10):1022-9

 

Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study.
RM Zagari, G Bianchi-Porro, R Fiocca, G Gasbarrini, E Roda, F Bazzoli, Gut. 2007 Apr:475-9

 

Effect of a community screening for Helicobacter pylori: a 5-Yr follow-up study.
Hansen JM, Wildner-Christensen M, Hallas J, Schaffalitzky de Muckadell OB, Am J Gastroenterol. 2008 May;103(5):1106-13

 

Proton pump inhibitor or testing for Helicobacter pylori as the first step for patients presenting with dyspepsia? A cluster-randomized trial.
DE Jarbol, J Kragstrup, H Stovring, T Havelund, OB Schaffalitzky de Muckadell, Am J Gastroenterol. 2006 Jun:1200-8

 

Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria.
Fang YJ, Liou JM, Chen CC, Lee JY, Hsu YC, Chen MJ, Tseng PH, Chen CC, Chang CY, Yang TH, Chang WH, Wu JY, Wang HP, Luo JC, Lin JT, Shun CT, Wu MS; Taiwan Gastrointestinal Disease and Helicobacter Consortium., Gut. 2015 Oct;64(10):1517-28. doi: 10.1136/gutjnl-2014-308114. Epub 2014 Nov 18.

 

Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk.
de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, BravoLE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM Jr,Cover TL, Correa P, Wilson KT., Gut. 2011 Sep;60(9):1189-95. Epub 2011 Feb 25.

 

Randomized comparison of two nonbismuth-containing rescue therapies forHelicobacter pylori.
Hu TH, Chuah SK, Hsu PI, Wu DC, Tai WC, Chiu YC, Wu KL, Kuo CM, Hu ML., Am J Med Sci. 2011 Sep;342(3):177-81.

 

Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacterpylori: a clinical trial.
Cammarota G, Branca G, Ardito F, Sanguinetti M, Ianiro G, Cianci R, Torelli R, Masala G, Gasbarrini A, Fadda G, Landolfi R, Gasbarrini G., Clin Gastroenterol Hepatol. 2010 Sep;8(9):817-820.e3. Epub 2010 May 31.

 

Clinical trial: prolonged beneficial effect of Helicobacter pylori eradication ondyspepsia consultations - the Bristol Helicobacter Project.
Harvey RF, Lane JA, Nair P, Egger M, Harvey I, Donovan J, Murray L., Aliment Pharmacol Ther. 2010 Aug;32(3):394-400. Epub 2010 May 18.

 

Rabeprazole can overcome the impact of CYP2C19 polymorphism on quadruple therapy.
Kuo CH, Wang SS, Hsu WH, Kuo FC, Weng BC, Li CJ, Hsu PI, Chen A, Hung WC, Yang YC, Wang WM, Wu DC., Helicobacter. 2010 Aug;15(4):265-72.

 

Differential effect of Helicobacter pylori eradication on time-trends inbrady/hypokinesia and rigidity in idiopathic parkinsonism.
Dobbs SM, Dobbs RJ, Weller C, Charlett A, Bjarnason IT, Lawson AJ, Letley D,Harbin L, Price AB, Ibrahim MA, Oxlade NL, Bowthorpe J, Leckstroem D, Smee C, Plant JM, Peterson DW., Helicobacter. 2010 Aug;15(4):279-94.

 

Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacterpylori: a clinical trial.
Cammarota G, Branca G, Ardito F, Sanguinetti M, Ianiro G, Cianci R, Torelli R, Masala G, Gasbarrini A, Fadda G, Landolfi R, Gasbarrini G., Clin Gastroenterol Hepatol. 2010 Sep;8(9):817-820.e3. Epub 2010 May 31.

 

A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole inrelation to pharmacokinetics and CYP2C19 polymorphism.
Hunfeld NG, Touw DJ, Mathot RA, Mulder PG, VAN Schaik RH, Kuipers EJ, Kooiman JC, Geus WP., Aliment Pharmacol Ther. 2010 Jan;31(1):150-9.

 

Sequential and concomitant therapy with four drugs is equally effective foreradication of H pylori infection.
Wu DC, Hsu PI, Wu JY, Opekun AR, Kuo CH, Wu IC, Wang SS, Chen A, Hung WC, Graham DY., Clin Gastroenterol Hepatol. 2010 Jan;8(1):36-41.e1. Epub 2009 Oct 3.

  

Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection.
Boonyaritichaikij S, Kuwabara K, Nagano J, Kobayashi K, Koga Y, Helicobacter. 2009 Jun;14(3):202-7

  

Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children.
Szajewska H, Albrecht P, Topczewska-Cabanek A, J Pediatr Gastroenterol Nutr. 2009 Apr;48(4):431-6

  

A randomized clinical trial to determine the efficacy of regimens containing clarithromycin, metronidazole, and amoxicillin among histologic subgroups for Helicobacter pylori eradication in a developing country.
Fischbach LA, Bravo LE, Zarama GR, Bravo JC, Ojha PR, Priest EL, Collazos T, Casabon LA, Guerrero LZ, Singh PK, Correa P, Helicobacter. 2009 Apr;14(2):100-8

  

Impact of quadruple regimen of clarithromycin added to metronidazole-containing triple therapy against Helicobacter pylori infection following clarithromycin-containing triple-therapy failure.
Ueki N, Miyake K, Kusunoki M, Shindo T, Kawagoe T, Futagami S, Tsukui T, Inagaki H, Sakamoto C, Helicobacter. 2009 Apr;14(2):91-9

  

Helicobacter pylori and gastroesophageal reflux disease: a case-control study.
Corley DA, Kubo A, Levin TR, Block G, Habel L, Rumore G, Quesenberry C, Buffler P, Parsonnet J, Helicobacter. 2008 Oct;13(5):352-60

  

Endoscopic diagnosis of Helicobacter pylori infection by rapid urease test in bleeding peptic ulcers: a prospective case-control study.
Tang JH, Liu NJ, Cheng HT, Lee CS, Chu YY, Sung KF, Lin CH, Tsou YK, Lien JM, Cheng CL, J Clin Gastroenterol. 2009 Feb;43(2):133-9

  

Helicobacter pylori eradication therapy success regarding different treatment period based on clarithromycin or metronidazole triple-therapy regimens.
Filipec Kanizaj T, Katicic M, Skurla B, Ticak M, Plecko V, Kalenic S, Helicobacter. 2009 Feb;14(1):29-35

  

Failure of Helicobacter pylori treatment after regimes containing clarithromycin: new practical therapeutic options.
Sanches B, Coelho L, Moretzsohn L, Vieira G Jr, Helicobacter. 2008 Dec;13(6):572-6

  

Helicobacter pylori eradication therapy may facilitate gastric ulcer healing after endoscopic mucosal resection: a prospective randomized study.
Cheon JH, Kim JH, Lee SK, Kim TI, Kim WH, Lee YC, Helicobacter. 2008 Dec;13(6):564-71

  

Evaluation of two triple-therapy regimens with metronidazole or clarithromycin for the eradication of H. pylori infection in Vietnamese children: a randomized, double-blind clinical trial.
Nguyen TV, Bengtsson C, Nguyen GK, Hoang TT, Phung DC, Sörberg M, Granström M, Helicobacter. 2008 Dec;13(6):550-6

  

Lafutidine versus lansoprazole in combination with clarithromycin and amoxicillin for one versus two weeks for Helicobacter pylori eradication in Korea.
Kim N, Park SH, Seo GS, Lee SW, Kim JW, Lee KJ, Shin WC, Kim TN, Park MI, Park JJ, Hong SJ, Shim KN, Kim SW, Shin YW, Chang YW, Chun HJ, Lee OJ, Jeon WJ, Park CG, Cho CM, Park CH, Won SY, Lee GH, Park KS, Shin JE, Kim HU, Park JY, Chae HS, Song GA, Kim JG, Yoon BC, Seol S, Jung HC, Chung IS, Helicobacter. 2008 Dec;13(6):542-9

  

Sustained epithelial proliferation in a functionally irreversible fundic mucosa after Helicobacter pylori eradication.
Iijima K, Koike T, Sekine H, Abe Y, Asanuma K, Ara N, Uno K, Imatani A, Ohara S, Shimosegawa T, J Gastroenterol. 2009;44(1):47-55

 

Efficacy of the Standard Quadruple Therapy Versus Triple Therapies Containing Proton Pump Inhibitor Plus Amoxicillin and Clarithromycin or Amoxicillin-Clavulanic Acid and Metronidazole for Helicobacter pylori Eradication in Children.
Dehghani SM, Erjaee A, Imanieh MH, Haghighat M, Dig Dis Sci. 2008 Nov 14;

 

Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children.
Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, Salam MA, Beglinger C, Gyr N, Fuchs GJ, Gastroenterology. 2008 Nov;135(5):1534-42

 

Association between hepatitis A virus and Helicobacter pylori in a developing country: the saga continues.
AR Bizri, IA Nuwayhid, GN Hamadeh, SW Steitieh, AM Choukair, UM Musharrafieh, J Gastroenterol Hepatol. 2006 Oct:1615-21

 

Cost-effectiveness of and satisfaction with a Helicobacter pylori "test and treat" strategy compared with prompt endoscopy in young Asians with dyspepsia.
Mahadeva S, Chia YC, Vinothini A, Mohazmi M, Goh KL, Gut 2008 Sep;57(9):1214-20

 

Effect of esomeprazole triple therapy on eradication rates of Helicobacter pylori, gastric ulcer healing and prevention of relapse in gastric ulcer patients.
Tulassay Z, Stolte M, Sjölund M, Engstrand L, Butruk E, Malfertheiner P, Dite P, Tchernev K, Wong BC, Gottlow M, Eklund S, Wrangstadh M, Nagy P, Eur J Gastroenterol Hepatol. 2008 Jun;20(6):526-36

 

Efficacy of a New Therapeutic Regimen Versus Two Routinely Prescribed Treatments for Eradication of Helicobacter Pylori: A Randomized, Double-Blind Study of Doxycycline, Co-Amoxiclav, and Omeprazole in Iranian Patients.
Taghavi SA, Jafari A, Eshraghian A, Dig Dis Sci. 2008 Jul 2;

 

Moxifloxacine Plus Amoxicillin and Ranitidine Bismuth Citrate or Esomeprazole Triple Therapies for Helicobacter pylori Infection.
Kiliç ZM, Köksal AS, Cakal B, Nadir I, Ozin YO, Kuran S, Sahin B, Dig Dis Sci. 2008 Dec;53(12):3133-3137

 

Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study.
Malfertheiner P, Schultze V, Rosenkranz B, Kaufmann SH, Ulrichs T, Novicki D, Norelli F, Contorni M, Peppoloni S, Berti D, Tornese D, Ganju J, Palla E, Rappuoli R, Scharschmidt BF, Del Giudice G, Gastroenterology. 2008 Sep;135(3):787-95