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Irritable Bowel Syndrome (IBS)

Level: Clinical Trials: 30 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

   

Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome.
Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J, Bethge J, Böttner M, Klose J, Milla PJ., Gastroenterology. 2014 Nov;147(5):1012-20.e4. doi: 10.1053/j.gastro.2014.07.046. Epub 2014 Jul 30.
Comments: A new insight into epithelial dysfunction in patients labeled as IBS

  

High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies.
Carroccio A, D'Alcamo A, Cavataio F, Soresi M, Seidita A, Sciumè C, Geraci G, Iacono G, Mansueto P., Gastroenterology. 2015 Sep;149(3):596-603.e1. doi: 10.1053/j.gastro.2015.05.040. Epub 2015 May 27.

  

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.
Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, Schmidt PT, Pedersen NL, Magnusson P, Talley NJ, Holliday EG, Houghton L, Gazouli M, Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki E, Gambaccini D, et al., Gut. 2015 Nov;64(11):1774-82. doi: 10.1136/gutjnl-2014-307997. Epub 2014 Sep 23.

  

Eluxadoline for Irritable Bowel Syndrome with Diarrhea.
Lembo AJ, Lacy BE, Zuckerman MJ, Schey R, Dove LS, Andrae DA, Davenport JM, McIntyre G, Lopez R, Turner L, Covington PS., N Engl J Med. 2016 Jan 21;374(3):242-53. doi: 10.1056/NEJMoa1505180.

  

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea.
Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G, Henry A, Hall I, Whorwell P, Spiller R., Gut. 2014 Oct;63(10):1617-25. doi: 10.1136/gutjnl-2013-305989. Epub 2013 Dec 12.
Comments: Another trial of ondansetron in IBS-D

  

Association between the location of diverticular disease and the irritable bowel syndrome: a multicenter study in Japan.
Yamada E, Inamori M, Uchida E, Tanida E, Izumi M, Takeshita K, Fujii T, Komatsu K, Hamanaka J, Maeda S, Kanesaki A, Matsuhashi N, Nakajima A., Am J Gastroenterol. 2014 Dec;109(12):1900-5. doi: 10.1038/ajg.2014.323. Epub 2014 Oct 21.
Comments: About relations between DD and IBS

  

Risk of irritable bowel syndrome in first-degree, second-degree and third-degree relatives of affected individuals: a nationwide family study in Sweden.
Waehrens R, Ohlsson H, Sundquist J, Sundquist K, Zöller B., Gut. 2015 Feb;64(2):215-21. doi: 10.1136/gutjnl-2013-305705. Epub 2014 Apr 2.
Comments: Familial clustering of IBS

  

Diets that differ in their FODMAP content alter the colonic luminal microenvironment.
Halmos EP, Christophersen CT, Bird AR, Shepherd SJ, Gibson PR, Muir JG., Gut. 2015 Jan;64(1):93-100. doi: 10.1136/gutjnl-2014-307264. Epub 2014 Jul 12.
Comments: Influence of diets on microbiota

 

MicroRNA-29a Regulates Intestinal Membrane Permeability in Patients with Irritable Bowel Syndrome.
Zhou Q, Souba WW, Croce CM, Verne GN, Gut. 2009 Dec 1;

 

Affective Disturbances Modulate the Neural Processing of Visceral Pain Stimuli in Irritable Bowel Syndrome: an fMRI Study.
Elsenbruch S, Rosenberger C, Enck P, Forsting M, Schedlowski M, Gizewski ER, Gut. 2009 Aug 2;

 

Fear of GI symptoms has an important impact on quality of life in patients with moderate-to-severe IBS.
Lackner JM, Gudleski GD, Ma CX, Dewanwala A, Naliboff B; Representing the IBSOS Outcome Study Research Group., Am J Gastroenterol. 2014 Nov;109(11):1815-23. doi: 10.1038/ajg.2014.241. Epub 2014 Sep 16.
Comments: Psy…

 

Rifaximin therapy for patients with irritable bowel syndrome without constipation.
Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, Bortey E, Forbes WP; TARGET Study Group., N Engl J Med. 2011 Jan 6;364(1):22-32.

 

Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial.
Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR., Am J Gastroenterol. 2011 Mar;106(3):508-14; quiz 515. Epub 2011 Jan 11.

 

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome.
Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE., Gut. 2010 Sep;59(9):1213-21. Epub 2010 Jul 21.

 

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.
Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.

 

Structured patient education is superior to written information in the management of patients with irritable bowel syndrome: a randomized controlled study.
Ringström G, Störsrud S, Posserud I, Lundqvist S, Westman B, Simrén M, Eur J Gastroenterol Hepatol. 2010 Apr;22(4):420-8

 

Pelvic floor disorders and quality of life in women with self-reported irritable bowel syndrome.
Wang J, Varma MG, Creasman JM, Subak LL, Brown JS, Thom DH, van den Eeden SK, Aliment Pharmacol Ther. 2010 Feb 1;31(3):424-31

 

No change in rectal sensitivity after gut-directed hypnotherapy in children with functional abdominal pain or irritable bowel syndrome.
Vlieger AM, van den Berg MM, Menko-Frankenhuis C, Bongers ME, Tromp E, Benninga MA, Am J Gastroenterol. 2010 Jan;105(1):213-8

 

Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders.
Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, Di Lorenzo C, Gastroenterology. 2009 Oct;137(4):1261-9

 

Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial.
Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Mann JD, Frey W, Leniek K, Whitehead WE., Am J Gastroenterol. 2011 Sep;106(9):1678-88. doi: 10.1038/ajg.2011.184. Epub 2011Jun 21.

 

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.
Rao AS, Wong BS, Camilleri M, Odunsi-Shiyanbade ST, McKinzie S, Ryks M, Burton D,Carlson P, Lamsam J, Singh R, Zinsmeister AR., Gastroenterology. 2010 Nov;139(5):1549-58, 1558.e1. Epub 2010 Aug 4.

 

A randomized, double-blind, placebo-controlled trial of polyethylene glycol effects on fasting and postprandial rectal sensitivity and symptoms in hypersensitive constipation-predominant irritable bowel syndrome.
Awad RA, Camacho S., Colorectal Dis. 2010 Nov;12(11):1131-8. doi: 10.1111/j.1463-1318.2009.01990.x.

 

Clinical trial on the efficacy of a new symbiotic formulation, Flortec, inpatients with acute diarrhea: a multicenter, randomized study in primary care.
Grossi E, Buresta R, Abbiati R, Cerutti R; Pro-DIA study group., J Clin Gastroenterol. 2010 Sep;44 Suppl 1:S35-41.

 

The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients.
Klooker TK, Leliefeld KE, Van Den Wijngaard RM, Boeckxstaens GE., Neurogastroenterol Motil. 2011 Jan;23(1):30-5, e2. doi:10.1111/j.1365-2982.2010.01587.x. Epub 2010 Aug 16.

 

Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation.
Johnston JM, Kurtz CB, Macdougall JE, Lavins BJ, Currie MG, Fitch DA, O'Dea C, Baird M, Lembo AJ., Gastroenterology. 2010 Dec;139(6):1877-1886.e2. Epub 2010 Aug 27.

 

Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome.
Ladabaum U, Sharabidze A, Levin TR, Zhao WK, Chung E, Bacchetti P, Jin C, Grimes B, Pepin CJ., Clin Gastroenterol Hepatol. 2010 Jan;8(1):42-48.e1. Epub 2009 Sep 16.

 

A randomized, double-blind, placebo-controlled trial of St John's wort for treating irritable bowel syndrome.
Saito YA, Rey E, Almazar-Elder AE, Harmsen WS, Zinsmeister AR, Locke GR, Talley NJ., Am J Gastroenterol. 2010 Jan;105(1):170-7. Epub 2009 Oct 6.

 

No change in rectal sensitivity after gut-directed hypnotherapy in children with functional abdominal pain or irritable bowel syndrome.
Vlieger AM, van den Berg MM, Menko-Frankenhuis C, Bongers ME, Tromp E, Benninga MA., Am J Gastroenterol. 2010 Jan;105(1):213-8. Epub 2009 Oct 27.

 

Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome.
Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S, Gowland PA, Spiller RC., Gastroenterology. 2010 Feb;138(2):469-77, 477.e1. Epub 2009 Nov 10.

  

Comprehensive Self-Management for Irritable Bowel Syndrome: Randomized Trial of In-Person vs. Combined In-Person and Telephone Sessions.
Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM, Am J Gastroenterol. 2009 Aug 18;

  

Do Corticotropin Releasing Factor-1 Receptors Influence Colonic Transit and Bowel Function in Females with Irritable Bowel Syndrome?
Sweetser S, Camilleri M, Linker Nord SJ, Burton DD, Castenada L, Croop R, Tong G, Dockens R, Zinsmeister AR, Am J Physiol Gastrointest Liver Physiol. 2009 Apr 2;

  

A Very Low-Carbohydrate Diet Improves Symptoms and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome.
Austin GL, Dalton CB, Hu Y, Morris CB, Hankins J, Weinland SR, Westman EC, Yancy WS Jr, Drossman DA, Clin Gastroenterol Hepatol. 2009 Mar 10;

  

The Clinical Course of Postinfectious Irritable Bowel Syndrome: A Five-year Follow-up Study.
Jung IS, Kim HS, Park H, Lee SI, J Clin Gastroenterol. 2009 Mar 3;