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World Gastroenterology Organisation
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Obesity

Level: Clinical Trials: 19 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

  

Effect of Metformin Added to Insulin on Glycemic Control Among Overweight/Obese Adolescents With Type 1 Diabetes: A Randomized Clinical Trial.
Libman IM, Miller KM, DiMeglio LA, Bethin KE, Katz ML, Shah A, Simmons JH, Haller MJ, Raman S, Tamborlane WV, Coffey JK, Saenz AM, Beck RW, Nadeau KJ; T1D Exchange Clinic Network Metformin RCT Study Group., JAMA. 2015 Dec 1;314(21):2241-50. doi: 10.1001/jama.2015.16174.

  

Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.
Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen-LABS Consortium., N Engl J Med. 2016 Jan 14;374(2):113-23. doi: 10.1056/NEJMoa1506699. Epub 2015 Nov 6.

  

Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial.
Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Nanni G, Castagneto M, Bornstein S, Rubino F., Lancet. 2015 Sep 5;386(9997):964-73. doi: 10.1016/S0140-6736(15)00075-6.

  

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.
Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjøth TV, Andreasen AH, Jensen CB, DeFronzo RA; NN8022-1922 Study Group., JAMA. 2015 Aug 18;314(7):687-99. doi: 10.1001/jama.2015.9676. Erratum in: JAMA. 2016 Jan 5;315(1):90.

  

Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial.
Basaria S, Harman SM, Travison TG, Hodis H, Tsitouras P, Budoff M, Pencina KM, Vita J, Dzekov C, Mazer NA, Coviello AD, Knapp PE, Hally K, Pinjic E, Yan M, Storer TW, Bhasin S., JAMA. 2015 Aug 11;314(6):570-81. doi: 10.1001/jama.2015.8881.

  

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease.
du Plessis J, van Pelt J, Korf H, Mathieu C, van der Schueren B, Lannoo M, Oyen T, Topal B, Fetter G, Nayler S, van der Merwe T, Windmolders P, Van Gaal L, Verrijken A, Hubens G, Gericke M, Cassiman D, Francque S, Nevens F, van der Merwe S., Gastroenterology. 2015 Sep;149(3):635-48.e14. doi: 10.1053/j.gastro.2015.05.044. Epub 2015 May 28.

  

High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery.
Xanthakos SA, Jenkins TM, Kleiner DE, Boyce TW, Mourya R, Karns R, Brandt ML, Harmon CM, Helmrath MA, Michalsky MP, Courcoulas AP, Zeller MH, Inge TH; Teen-LABS Consortium., Gastroenterology. 2015 Sep;149(3):623-34.e8. doi: 10.1053/j.gastro.2015.05.039. Epub 2015 May 28.

  

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G, Kraus WE, Eggebeen J, Nicklas BJ., JAMA. 2016 Jan 5;315(1):36-46. doi: 10.1001/jama.2015.17346.

  

Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents.
Inge TH, Courcoulas AP, Jenkins TM, Michalsky MP, Helmrath MA, Brandt ML, Harmon CM, Zeller MH, Chen MK, Xanthakos SA, Horlick M, Buncher CR; Teen-LABS Consortium., N Engl J Med. 2016 Jan 14;374(2):113-23. doi: 10.1056/NEJMoa1506699. Epub 2015 Nov 6.

 

Weight loss, exercise, or both and physical function in obese older adults.
Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R,Napoli N, Qualls C, Shah K., N Engl J Med. 2011 Mar 31;364(13):1218-29.

 

Intestinal adaptation after ileal interposition surgery increases bile acidrecycling and protects against obesity-related comorbidities.
Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT,Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ., Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60. Epub 2010 Jul1.

  

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.
Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP; SCALE Obesity and Prediabetes NN8022-1839 Study Group., N Engl J Med. 2015 Jul 2;373(1):11-22. doi: 10.1056/NEJMoa1411892.
 

 

Weight loss, cardiovascular risk factors, and quality of life after gastricbypass and duodenal switch: a randomized trial.
Søvik TT, Aasheim ET, Taha O, Engström M, Fagerland MW, Björkman S, Kristinsson J, Birkeland KI, Mala T, Olbers T., Ann Intern Med. 2011 Sep 6;155(5):281-91.

 

Effects of diet and physical activity interventions on weight loss andcardiometabolic risk factors in severely obese adults: a randomized trial.
Goodpaster BH, Delany JP, Otto AD, Kuller L, Vockley J, South-Paul JE, Thomas SB,Brown J, McTigue K, Hames KC, Lang W, Jakicic JM., JAMA. 2010 Oct 27;304(16):1795-802. Epub 2010 Oct 9.

 

Diets with high or low protein content and glycemic index for weight-lossmaintenance.
Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, Pfeiffer AF, Martinez JA, Handjieva-Darlenska T, Kunešová M, Pihlsgård M, Stender S, Holst C, Saris WH, Astrup A; Diet, Obesity, and Genes (Diogenes) Project., N Engl J Med. 2010 Nov 25;363(22):2102-13.

 

Surgical removal of omental fat does not improve insulin sensitivity andcardiovascular risk factors in obese adults.
Fabbrini E, Tamboli RA, Magkos F, Marks-Shulman PA, Eckhauser AW, Richards WO, Klein S, Abumrad NN., Gastroenterology. 2010 Aug;139(2):448-55. Epub 2010 May 7.

 

Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial.
Foster GD, Wyatt HR, Hill JO, Makris AP, Rosenbaum DL, Brill C, Stein RI, Mohammed BS, Miller B, Rader DJ, Zemel B, Wadden TA, Tenhave T, Newcomb CW, Klein S., Ann Intern Med. 2010 Aug 3;153(3):147-57.

 

Sibutramine--another flawed diet pill.
Curfman GD, Morrissey S, Drazen JM., N Engl J Med. 2010 Sep 2;363(10):972-4.

 

Visceral obesity and insulin resistance as risk factors for colorectal adenoma: a cross-sectional, case-control study.
Kang HW, Kim D, Kim HJ, Kim CH, Kim YS, Park MJ, Kim JS, Cho SH, Sung MW, Jung HC, Lee HS, Song IS, Am J Gastroenterol. 2010 Jan;105(1):178-87

 

Effect of a free prepared meal and incentivized weight loss program on weightloss and weight loss maintenance in obese and overweight women: a randomizedcontrolled trial.
Rock CL, Flatt SW, Sherwood NE, Karanja N, Pakiz B, Thomson CA., JAMA. 2010 Oct 27;304(16):1803-10. Epub 2010 Oct 9.

 

A school-based intervention for diabetes risk reduction.
HEALTHY Study Group, Foster GD, Linder B, Baranowski T, Cooper DM, Goldberg L, Harrell JS, Kaufman F, Marcus MD, Treviño RP, Hirst K., N Engl J Med. 2010 Jul 29;363(5):443-53.

 

Effect of naltrexone plus bupropion on weight loss in overweight and obese adults(COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3trial.
Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, Kim DD, Dunayevich E; COR-I Study Group., Lancet. 2010 Aug 21;376(9741):595-605. Epub 2010 Jul 29.

 

Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised,multicentre, placebo-controlled trial.
Topol EJ, Bousser MG, Fox KA, Creager MA, Despres JP, Easton JD, Hamm CW, Montalescot G, Steg PG, Pearson TA, Cohen E, Gaudin C, Job B, Murphy JH, Bhatt DL; CRESCENDO Investigators., Lancet. 2010 Aug 14;376(9740):517-23.

 

Effect of sibutramine on cardiovascular outcomes in overweight and obesesubjects.
James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP,Torp-Pedersen C, Sharma AM, Shepherd GM, Rode RA, Renz CL; SCOUT Investigators., N Engl J Med. 2010 Sep 2;363(10):905-17.

 

Effects of diet and physical activity interventions on weight loss andcardiometabolic risk factors in severely obese adults: a randomized trial.
Goodpaster BH, Delany JP, Otto AD, Kuller L, Vockley J, South-Paul JE, Thomas SB,Brown J, McTigue K, Hames KC, Lang W, Jakicic JM., JAMA. 2010 Oct 27;304(16):1795-802. Epub 2010 Oct 9.

 

Effect of a free prepared meal and incentivized weight loss program on weightloss and weight loss maintenance in obese and overweight women: a randomizedcontrolled trial.
Rock CL, Flatt SW, Sherwood NE, Karanja N, Pakiz B, Thomson CA., JAMA. 2010 Oct 27;304(16):1803-10. Epub 2010 Oct 9.

 

Improvement in peripheral glucose uptake after gastric bypass surgery is observedonly after substantial weight loss has occurred and correlates with the magnitudeof weight lost.
Campos GM, Rabl C, Peeva S, Ciovica R, Rao M, Schwarz JM, Havel P, Schambelan M, Mulligan K., J Gastrointest Surg. 2010 Jan;14(1):15-23. Epub 2009 Oct 17.

 

Laparoscopic adjustable gastric banding in severely obese adolescents: arandomized trial.
O'Brien PE, Sawyer SM, Laurie C, Brown WA, Skinner S, Veit F, Paul E, Burton PR, McGrice M, Anderson M, Dixon JB., JAMA. 2010 Feb 10;303(6):519-26.