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World Gastroenterology Organisation
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Probiotics and Prebiotics

Level: Clinical Trials: 16 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

 

The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis.
Sood A, Midha V, Makharia GK, Ahuja V, Singal D, Goswami P, Tandon RK, Clin Gastroenterol Hepatol. 2009 Nov;7(11):1202-9, 1209.e1

 

Survival of the probiotic Escherichia coli Nissle 1917 (EcN) in the gastrointestinal tract given in combination with oral mesalamine to healthy volunteers.
Joeres-Nguyen-Xuan TH, Boehm SK, Joeres L, Schulze J, Kruis W, Inflamm Bowel Dis. 2009 Jul 27;

 

Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis.
Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A, Am J Gastroenterol. 2009 Feb;104(2):437-43

  

Probiotic VSL#3 reduces liver disease severity and hospitalization in patients with cirrhosis: a randomized, controlled trial.
Dhiman RK, Rana B, Agrawal S, Garg A, Chopra M, Thumburu KK, Khattri A, Malhotra S, Duseja A, Chawla YK., Gastroenterology. 2014 Dec;147(6):1327-37.e3. doi: 10.1053/j.gastro.2014.08.031. Epub 2014 Aug 27.

Comments: Needs confirmation about VSL=3 in treatment and/or prophylaxis of HE

 

Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation.
Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, Goupil Feuillerat N, Schlumberger A, Jakob S, Whorwell PJ, Aliment Pharmacol Ther. 2008 Sep 17;

 

Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study.
Williams E, Stimpson J, Wang D, Plummer S, Garaiova I, Barker M, Corfe B, Aliment Pharmacol Ther. 2008 Sep 10;

 

Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial.
Costeloe K, Hardy P, Juszczak E, Wilks M, Millar MR; Probiotics in Preterm Infants Study Collaborative Group., Lancet. 2016 Feb 13;387(10019):649-60. doi: 10.1016/S0140-6736(15)01027-2. Epub 2015 Nov 28.

 

Intake of Lactobacillus plantarum reduces certain gastrointestinal symptoms during treatment with antibiotics.
Lönnermark E, Friman V, Lappas G, Sandberg T, Berggren A, Adlerberth I., J Clin Gastroenterol. 2010 Feb;44(2):106-12.

 

Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study.
Simrén M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H, Aliment Pharmacol Ther. 2010 Jan 15;31(2):218-27

 

Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy.
Tsuda Y, Yoshimatsu Y, Aoki H, Nakamura K, Irie M, Fukuda K, Hosoe N, Takada N, Shirai K, Suzuki Y, Scand J Gastroenterol. 2007 Nov;42(11):1306-11

 

Survival of the probiotic Escherichia coli Nissle 1917 (EcN) in the gastrointestinal tract given in combination with oral mesalamine to healthy volunteers.
Joeres-Nguyen-Xuan TH, Boehm SK, Joeres L, Schulze J, Kruis W., Inflamm Bowel Dis. 2010 Feb;16(2):256-62.

  

Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of Helicobacter pylori infection.
Boonyaritichaikij S, Kuwabara K, Nagano J, Kobayashi K, Koga Y, Helicobacter. 2009 Jun;14(3):202-7

  

A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids.
Underwood MA, Salzman NH, Bennett SH, Barman M, Mills DA, Marcobal A, Tancredi DJ, Bevins CL, Sherman MP, J Pediatr Gastroenterol Nutr. 2009 Feb;48(2):216-25

 

Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota.
Kajander K, Myllyluoma E, Rajilic-Stojanovic M, Kyrönpalo S, Rasmussen M, Järvenpää S, Zoetendal EG, de Vos WM, Vapaatalo H, Korpela R, Aliment Pharmacol Ther. 2008 Jan 1;27(1):48-57

 

Intestinal permeability and effects of Lactobacillus rhamnosus therapy in children with short bowel syndrome.
Sentongo TA, Cohran V, Korff S, Sullivan C, Iyer K, Zheng X, J Pediatr Gastroenterol Nutr. 2008 Jan;46(1):41-7

 

The effect of a multispecies probiotic on the intestinal microbiota and bowel movements in healthy volunteers taking the antibiotic amoxycillin.
Koning CJ, Jonkers DM, Stobberingh EE, Mulder L, Rombouts FM, Stockbrügger RW, Am J Gastroenterol. 2008 Jan;103(1):178-89

 

The effect of probiotics on gut flora, level of endotoxin and Child-Pugh score in cirrhotic patients: results of a double-blind randomized study.
Lata J, Novotný I, Príbramská V, Juránková J, Fric P, Kroupa R, Stiburek O, Eur J Gastroenterol Hepatol. 2007 Dec;19(12):1111-3