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Probiotics and Prebiotics

Level: Meta-analyses, Systematic reviews, Practice guidelines: 24 Abstracts

Legend: : Key Development,  : Very Important,  : Important, [no star]: Special Mention

 

Probiotics for prevention of necrotizing enterocolitis in preterm infants.
AlFaleh K, Anabrees J., Cochrane Database Syst Rev. 2014 Apr 10;4:CD005496. doi:10.1002/14651858.CD005496.pub4.

Comments: Cochrane review documenting that enteral supplementation of probiotics prevents severe necrotizing enterocolitis and all cause mortality in preterm infants, necessitating a change in practice.

 

Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.
Goldenberg JZ, Ma SS, Saxton JD, Martzen MR, Vandvik PO, Thorlund K, Guyatt GH, Johnston BC., Cochrane Database Syst Rev. 2013 May 31;5:CD006095. doi:10.1002/14651858.CD006095.pub3.

Comments: Meta analysis showing that probiotics are safe and effective for in preventing Clostridium difficile-associated diarrhea.

 

An update on the use and investigation of probiotics in health and disease.
Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM, Mayer EA., Gut. 2013 May;62(5):787-96. doi: 10.1136/gutjnl-2012-302504. Epub 2013 Mar 8.

 

Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea inadult hospitalized patients: a single-center, randomized, double-blind,placebo-controlled trial.
Pozzoni P, Riva A, Bellatorre AG, Amigoni M, Redaelli E, Ronchetti A, Stefani M, Tironi R, Molteni EE, Conte D, Casazza G, Colli A., Am J Gastroenterol. 2012 Jun;107(6):922-31. doi: 10.1038/ajg.2012.56. Epub 2012Apr 3.

Comments: In this study of elderly hospitalized patients, S. boulardii was not effective in preventing the development of AAD.

 

Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells inhuman peripheral blood: potential role for myeloid and plasmacytoid dendriticcells.
Konieczna P, Groeger D, Ziegler M, Frei R, Ferstl R, Shanahan F, Quigley EM, Kiely B, Akdis CA, O'Mahony L., Gut. 2012 Mar;61(3):354-66. doi: 10.1136/gutjnl-2011-300936. Epub 2011 Nov 3.

Comments: Volunteers fed B. infantis displayed a selective increase in secretion of interleukin (IL)-10 and enhanced Foxp3 expression in peripheral blood.

 

Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC., Cochrane Database Syst Rev. 2015 Dec 22;12:CD004827. doi: 10.1002/14651858.CD004827.pub4. Review.

 

Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis.
Li BZ, Threapleton DE, Wang JY, Xu JM, Yuan JQ, Zhang C, Li P, Ye QL, Guo B, Mao C, Ye DQ., BMJ. 2015 Aug 19;351:h4052. doi: 10.1136/bmj.h4052. Review.

 

Probiotics for preventing ventilator-associated pneumonia.
Bo L, Li J, Tao T, Bai Y, Ye X, Hotchkiss RS, Kollef MH, Crooks NH, Deng X., Cochrane Database Syst Rev. 2014 Oct 25;10:CD009066. doi: 10.1002/14651858.CD009066.pub2. Review.
Comments: Meta-analysis of 8 RCT using a lot of different probiotics...

 

Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis.
Ford AC, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, Spiegel BM, Moayyedi P., Am J Gastroenterol. 2014 Oct;109(10):1547-61; quiz 1546, 1562. doi: 10.1038/ajg.2014.202. Epub 2014 Jul 29. Review.

Comments: Meta-analysis of probiotics in IBS

 

Probiotics for preventing gestational diabetes.
Barrett HL, Dekker Nitert M, Conwell LS, Callaway LK., Cochrane Database Syst Rev. 2014 Feb 27;2:CD009951. doi:10.1002/14651858.CD009951.pub2.

Comments: Currently, there are insufficient studies to sustain the use of probiotics early in pregnancy to prevent miscarriage/IUFD/stillbirth/neonatal death.

 

Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis.
Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta AM, Zarychanski R., BMJ. 2013 Dec 4;347:f6471. doi: 10.1136/bmj.f6471.

Comments: Twenty (20) eligible trials including 4,866 children did not support a protective association between perinatal use of probiotics and asthma or childhood wheeze.

 

Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial.
Allen SJ, Wareham K, Wang D, Bradley C, Hutchings H, Harris W, Dhar A, Brown H, Foden A, Gravenor MB, Mack D., Lancet. 2013 Oct 12;382(9900):1249-57. doi: 10.1016/S0140-6736(13)61218-0. Epub2013 Aug 8.

Comments: 1470 pts assigned to a multistrain preparation of lactobacilli and bifidobacteria ( 6 ? 10(10) organisms, one per day for 21 days) vs 1471 pts to an identical placebo: no evidence of effect in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea .

 

Probiotics for treating persistent diarrhoea in children.
Bernaola Aponte G, Bada Mancilla CA, Carreazo NY, Rojas Galarza RA., Cochrane Database Syst Rev. 2013 Aug 20;8:CD007401. doi:10.1002/14651858.CD007401.pub3.

Comments: There is limited evidence suggesting that probiotics may be effective in persistent diarrhoea in children.

 

Probiotics for the prevention of Clostridium difficile-associated diarrhea: as ystematic review and meta-analysis.
Johnston BC, Ma SS, Goldenberg JZ, Thorlund K, Vandvik PO, Loeb M, Guyatt GH., Ann Intern Med. 2012 Dec 18;157(12):878-88.

 

Intestinal microbiota in functional bowel disorders: a Rome foundation report.
Simrén M, Barbara G, Flint HJ, Spiegel BM, Spiller RC, Vanner S, Verdu EF, Whorwell PJ, Zoetendal EG; Rome Foundation Committee., Gut. 2013 Jan;62(1):159-76. doi: 10.1136/gutjnl-2012-302167. Epub 2012 Jun 22.

 

Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis.
Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, Johnsen B, Shekelle PG., JAMA. 2012 May 9;307(18):1959-69. doi: 10.1001/jama.2012.3507.

Comments: The pooled evidence seems to suggest that probiotics are associated with a reduction in antibiotic-associated diarrhea;

 

Does taking probiotics routinely with antibiotics prevent antibiotic associated diarrhoea?
Butler CC, Duncan D, Hood K., BMJ. 2012 Feb 21;344:e682. doi: 10.1136/bmj.e682.

 

The efficacy of probiotics in the treatment of irritable bowel syndrome: asystematic review.
Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EM., Gut. 2010 Mar;59(3):325-32. Epub 2008 Dec 17.

 

Interventions for treating microscopic colitis: a Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Review Group systematic review of randomized trials.
Chande N, MacDonald JK, McDonald JW, Am J Gastroenterol. 2009 Jan;104(1):235-41; quiz 234, 242

 

The efficacy of probiotics in the therapy of irritable bowel syndrome: a systematic review.
Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein A, Brandt L, Quigley E, Gut. 2008 Dec 17;

 

Prevention and treatment of the common cold: making sense of the evidence.
Allan GM, Arroll B., CMAJ. 2014 Feb 18;186(3):190-9. doi: 10.1503/cmaj.121442. Epub 2014 Jan 27.

 

Probiotics for preventing acute upper respiratory tract infections.
Hao Q, Lu Z, Dong BR, Huang CQ, Wu T., Cochrane Database Syst Rev. 2011 Sep 7;9:CD006895.

  

The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review.
Brenner DM, Moeller MJ, Chey WD, Schoenfeld PS, Am J Gastroenterol. 2009 Apr;104(4):1033-49; quiz 1050

 

Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials.
Sachdeva A, Nagpal J, Eur J Gastroenterol Hepatol. 2009 Jan;21(1):45-53

 

On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials.
Elahi B, Nikfar S, Derakhshani S, Vafaie M, Abdollahi M, Dig Dis Sci. 2008 May;53(5):1278-84

 

Probiotics for necrotizing enterocolitis: a systematic review.
Barclay AR, Stenson B, Simpson JH, Weaver LT, Wilson DC, J Pediatr Gastroenterol Nutr. 2007 Nov;45(5):569-76