World Gastroenterology Organisation (WGO) - Global Guardian of Digestive Health. Serving the World.

World Digestive Health Day 2006 - Helicobacter Pylori Infection

In October 2005, Barry J. Marshall and J. Robin Warren won the 2005 Nobel Prize for their discovery of the helicobacter pylori bacteria. To honour this achievement and spotlight the importance of this bacteria to world health, WGO focussed World Digestive Health Day 2006 on helicobacter pylori infection.

Helicobacter pylori is not only the most important risk factor for non cardia gastric cancer, but H. pylori infection accounts for more than 60% of the global cases of gastric cancer.

View WGO guideline on Helicobacter Pylori Infection

To provide educational tools to members, on World Digestive Health Day 2006, WGO released a new guideline on Helicobacter Pylori Infection. This guideline was written by a team of international experts, includes a foreword from Barry J. Marshall and is available for free in six languages (English, French, Mandarin, Portuguese, Russian, Spanish)

Highlights of the Helicobacter Pylori Infection Guideline:

  • Quadruple therapies (PPIs + antibiotics + bismuth) are cheaper than triple therapies and just as effective. Both therapies provide very high eradication rates.
  • The current emphasis on triple therapy developed for historical reasons and is hard to justify purely on evidence-based grounds
  • Key good practice point: "Take time to explain the complex regimen to the patient- this will improve compliance "
  • Metronidazole and Clarithromycin resistance reduce eradication rates
  • No large differences in outcome between 14, 10 and 7 days therapy except cost.
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