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8 WORLD GASTROENTEROLOGY NEWS OCTOBER 2014 Editorial | Expert Point of View | Gastro 2015: AGW/WGO | WDHD News | WGO & WGOF News | WGO Global Guidelines | Calendar of Events of pathomechanistic processes, but also to screen patients for different therapeutic modalities. References: 1. Fasano, A., Shea-Donohue, T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal au-toimmune diseases. Nature Clinical Practice. 2005;2(9):416-22. 2. Levesque, G. B, Sandborn, J. W, Ruel, J., et al. Converging Goals of Treatment for Inflammatory Bowel Disease, from Clinical Trials and Practice. Gastroenterology. 2014. 3. Pastorelli, L., Salvo D, C., Mer-cado, R. J, et al. Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Frontiers in Immunology. 2013;4:280. 4. Schultz, M., Veltkamp, C., Di-eleman, A. L, et al. Lactobacillus plantarum 299v in treatment and prevention of spontaneous colitis in IL-10-deficient mice. Inflammatory Bowel Disease. 2002;8:71-80. 5. Grossmann, J., Walther, K., Art-inger, M., et al. Progress on isola-tion and short-term ex-vivo culture of highly purified non-apoptotic human intestinal epithelial cells (IEC). European Journal of Cell Biology. 2003;82(5):262-70. 6. Sato, T., Vries, G. R, Snippert, J. H, et al. Single Lgr5 stem cells build crypt-villus structures in vi-tro without a mesenchymal niche. Nature. 2009;459(7244):262-5. 7. Stelzner, M., Helmrath, M., Dunn, C. J, et al. A nomenclature for intestinal in vitro cultures. American Journal of Physiolology. 2012;302(12):G1359-63. 8. Barker, N., Huch, M., Kujala, P., et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell stem Cell. 2010;6(1):25-36. 9. Sato, T., Stange, E. D, Ferrante, M., et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastro-enterology. 2011;141(5):1762-72. 10. Wilson, S. S, Tocchi, A., Holly, K. M, et al. A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol-ogy. 2014. 11. Wehkamp, J., Salzman, H. N, Porter, E., et al. Reduced Pan-eth cell alpha-defensins in ileal Crohn’s disease. Proceedings of the National Academy of Sciences U S A. 2005;102(50):18129-34. 12. Shanahan, T. M, Carroll, M. I, Grossniklaus, E., et al. Mouse Paneth cell antimicrobial func-tion is independent of Nod2. Gut. 2014;63(6):903-10. 13. Wroblewski, E. L, Piazuelo, B. M, Chaturvedi, R., et al. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. 2014. 14. Tsukashita, S., Kushima, R., Bamba, M., et al. Beta-catenin expression in intramucosal neoplastic lesions of the stomach. Comparative analysis of adenoma/ dysplasia, adenocarcinoma and signet-ring cell carcinoma. Oncol-ogy. 2003;64(3):251-8. 15. Sachs, N., Clevers, H. Organoid cultures for the analysis of cancer phenotypes. Current Opinion in Genetics & Development. 2014;24:68-73. 16. Li, S. V, Clevers, H. In vitro expansion and transplantation of intestinal crypt stem cells. Gastro-enterology. 2012;143(1):30-4.


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